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Preparation technology and production method of a new integrated dosage form of Jichuan decoction

A production method and technology of a new dosage form, which are applied in the field of the preparation of a new integrated dosage form of Jichuanjian, can solve the problems such as the reduction of cholesterol absorption rate, and achieve the effects of wide target distribution and strong slow and controlled release performance.

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alisterpenol A has the ability to inhibit the esterification of cholesterol in the small intestine of mice and reduce the absorption rate of cholesterol in the small intestine of rats

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0048] The raw materials for making the effective ingredients are as follows: 15 parts of angelica, 6 parts of Achyranthes bidentata, 9 parts of cistanche, 5 parts of Alisma, 3 parts of Cimicifuga and 3 parts of Citrus aurantii.

[0049] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform i...

Embodiment 2

[0051] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0052] The raw materials for making the effective ingredients are as follows: 15 parts of angelica, 6 parts of Achyranthes bidentata, 9 parts of cistanche, 5 parts of Alisma, 3 parts of Cimicifuga and 3 parts of Citrus aurantii.

[0053] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally,...

Embodiment 3

[0055] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0056] The raw materials for making the effective ingredients are as follows: 15 parts of angelica, 6 parts of Achyranthes bidentata, 9 parts of cistanche, 5 parts of Alisma, 3 parts of Cimicifuga and 3 parts of Citrus aurantii.

[0057] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. ...

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Abstract

The invention relates to a preparation technology and a production method of a new integrated dosage form of Jichuan decoction. The raw material composition of the active ingredients is as follows: 15 parts of angelica, 6 parts of Achyranthes bidentata, 9 parts of Cistanche deserticola, 5 parts of Alisma, liter 3 parts of hemp, 3 parts of Citrus aurantium. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Jichuan decoction, and also relates to a preparation technology of a new integrated dosage form of Jichuan decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, ...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/14A61K9/16A61K9/127A61K9/107A61K9/50A61K9/70A61K9/10A61K9/00A61P13/12A61P1/10
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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