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Intrauterine device material capable of adjusting and controlling release rate of copper ions

An intrauterine device and release rate technology, applied in the directions of amine active ingredients, amide active ingredients, ketone active ingredients, etc., can solve problems such as unsatisfactory effects, and achieve the effect of prolonging service life

Active Publication Date: 2010-06-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, our research results show that in the case of a certain amount of copper particles added, the effect of adjusting the release rate of copper ions by changing the crystal structure of the matrix and optimizing the preparation process of IUD is not ideal.

Method used

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  • Intrauterine device material capable of adjusting and controlling release rate of copper ions
  • Intrauterine device material capable of adjusting and controlling release rate of copper ions
  • Intrauterine device material capable of adjusting and controlling release rate of copper ions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 25g of nano-copper particles and 75g of medical-grade low-density polyethylene (LDPE), and use methods such as premixing, blending, pressure injection or injection molding to prepare a Cu / LDPE composite IUD without adding soluble biomaterials such as glucose or starch .

Embodiment 2

[0023] Weigh 25g of micron copper particles, 72.5g of medical grade low-density polyethylene (LDPE), 2.0g of glucose, and 0.5g of starch, and use premixing, blending, pressure injection or injection molding to prepare soluble Cu / LDPE composite IUD of biomaterials.

[0024] Examples 3-18 were all prepared by a method similar to that of Example 1 and Example 2, wherein the composition of the prepared Cu / LDPE composite IUD is shown in Table 1.

[0025] The composition of composite material IUD in each embodiment of table 1

[0026]

[0027]

[0028] Select several examples of the above-mentioned composite material IUDs prepared, place them in 20ml of simulated intrauterine fluid at 37±0.1°C, and measure the release rate of copper ions. The test results are as follows: figure 2 and image 3 shown.

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Abstract

The invention discloses an intrauterine device material capable of adjusting and controlling release rate of copper ions. The material comprises copper particles, low-density polyethylene and a soluble biological material. The weight percentage of the soluble biological material accounts for 0.5-10% of the total weight of the intrauterine device material, preferably 2.5-7.5%. The soluble biological material is one or both of glucose and starch. The intrauterine device made from the intrauterine device material can greatly improve the release rate of the copper particles under the condition of constant copper particle content in the Cu / LDPE composite material IUD, the time for the Cu / LDPE composite material IUD to release the minimum copper ion concentration to inhibit sperm activity capability in uterine liquid is greatly prolonged, and therefore, the purpose for prolonging the service life of the composite material IUD is achieved.

Description

technical field [0001] The invention relates to an intrauterine device material, in particular to an intrauterine device material capable of regulating the release rate of copper ions, which is loaded with glucose alone or in combination in a copper / low-density polyethylene (Cu / LDPE) composite material or soluble biomaterials such as starch. technical background [0002] China is a developing country with a population of 1.3 billion. The huge population base has always been one of the most notable characteristics of China's national conditions. Although China has now entered the ranks of countries with low fertility rates, due to the inertial effect of population growth, China's population will still grow at an average annual rate of 8-10 million in the current and next ten years. The population problem is a problem that China will face for a long time in the primary stage of socialism, and it is a key factor related to China's economic and social development. Solving the ...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K31/16A61K31/14
Inventor 夏先平谢长生王芸汤滢蔡水洲朱长虹
Owner HUAZHONG UNIV OF SCI & TECH
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