Cefuroxime sodium and preparation method thereof

Abstract

The invention provides cefuroxime sodium and a preparation method thereof. The preparation method comprises the following steps that: (1) 7-aminocephalosporanic acid reacts with 2-(furan-2-base)-2-(methoxyimino) acetyl chloride to produce 3-deacety-7-aminocephalosporanic acid; (2) crystallization is conducted after the 3-deacety-7-aminocephalosporanic acid reacts with chlorosulfonyl isocyanate to produce cefuroxime acid; and (3) the cefuroxime acid is salified to obtain the cefuroxime sodium, wherein solvent for crystallization is selected from one or more of petroleum ether, normal hexane, cyclohexane, solvent oil and tetrahydrofuran. Since the preparation method adopts solvents such as petroleum ether for crystallization in the process of the preparation of the cefuroxime acid, the invention has the advantages that the yield of the product is effectively improved, the product purity is further improved, the impurity content is reduced, the product quality is compliant with Chinese Pharmacopoeia of version 2005, the operation of the method is simple, the raw materials can be easily obtained, the cost is relatively low and the industrial production can be realized easily.

Description

technical field The invention belongs to the technical field of drug synthesis, and relates to a cephalosporin antibiotic and a preparation method thereof, in particular to cefuroxime sodium and a preparation method thereof. Background technique Cefuroxime sodium is the sodium salt of cefuroxime, which belongs to the second-generation cephalosporin antibiotics. It has a broad antibacterial spectrum and is effective against most Gram-negative bacteria, including Haemophilus influenzae, Neisseria gonorrhoeae, meningococcus, Escherichia coli, Klebsiella, Proteus mirabilis, Enterobacter, Citrobacter, Salmonella Bacteria, Shigella, and certain indole-positive denatured bacilli. The antibacterial spectrum against gram-positive bacteria is similar to that of cephalexin, mainly including staphylococci and streptococci. This product is relatively stable to β-lactamase, and its stability is no less than that of the third-generation cephalosporins. It is stable to almost all standard...

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Problems solved by technology

In this synthetic method, the generated intermediate product cefuroxime acid is directly salified without treatment, resulting in a low product yield, only 85%.

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