120results about How to "Reduce nephrotoxicity" patented technology

The invention relates to a fluorine-containing optically active composition for anti-infection, in particular to a quinolones optically active fluorine-containing composition anti-infective drug, i.e. a quinolones optically active fluorine-containing composition 1 showed by a right formula, wherein HA in the right formula is organic acid or inorganic acid which can form a composition accepted by pharmacology with (S)-6-fluorine-1-methyl-4-oxo-7-(1-piperazinyl)-1H and 4H-(1, 3) sulfur azetidine combined with (3, 2-a) quinoline-3-carboxylic acid. The quinolones optically active fluorine-containing composition 1 has stable property; compared with ulifloxacin, the quinolones optically active fluorine-containing composition 1 improves the water solubility and lowers the pH value of a water solution, is easy to dissolve in water and has higher biological activity, little renal toxicity and no skin and muscle irritation; the drug level of unobserved untoward effect is 30 mg / kg and is enhanced by 10 times comparing with the ulifloxacin, thus the quinolones optically active fluorine-containing composition 1 has low side effect and wide antimicrobial spectrum, and the activity of the quinolones optically active fluorine-containing composition 1 is 1-3 times higher than that of the racemic ulifloxacin.

Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and / or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

Disclosed are disulfide and thioester derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

Disclosed are glycopeptide derivatives substituted at the C-terminus and / or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.