72 results about "Smart polymer" patented technology

Polymeric nanoparticles with a hydrophobic core and a hydrophilic shell are formed from: 1) N-isopropyl acrylamide (NIPAAM), at a molar ratio of about 50% to about 90%, and preferably 60% for specific delivery routes such as oral or parenteral; either water-soluble vinyl derivatives like vinylpyrolidone (VP) or vinyl acetate (VA), or water insoluble vinyl derivatives like methyl methacrylate (MMA) or styrene (ST), at a molar ratio of about 10% to about 30%; and acrylic acid (AA), at a molar ratio of about 10% to about 30%. The formed nanoparticles may be optionally surface functionalized using reactive groups present in AA, including PEGylation, or conjugation of moieties such as chemotherapeutics, contrasting agents, antibodies, radionucleides, ligands, and sugars, for diagnostic, therapeutic, and imaging purposes. The polymeric nanoparticles are preferably dispersed in aqueous solutions. The polymeric nanoparticles incorporate one or more types of medicines or bioactive agents in the hydrophobic core; on occasion, the medicine or bioactive agent may be conjugated to the nanoparticle surface via reactive functional groups. The polymeric nanoparticles are capable of delivering the said medicines or bioactive agents through oral, parenteral, or topical routes. The polymeric nanoparticles allow poorly water soluble medicines or bioactive agents, or those with poor oral bioavailability, to be formulated in an aqueous solution, and enable their convenient delivery into the systemic circulation.

An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet containing the said pharmaceutically active substances, with / without suitable pharmaceutical excipients in intimate mixture with two groups of intelligent polymers having opposing wettability characteristics, one demonstrating a stronger tendency towards hydrophobicity and the other a stronger tendency towards hydrophilicity, the polymer combination being between the ratios of 1:50 and 50:1 amounts effective to control the release of said pharmaceutically active substances in a mathematically predictable manner, wherein the polymer demonstrating a stronger tendency towards hydrophobicity is not less than 5% wt / wt and preferably between 5-70% wt / wt of the final formulation composition. The intelligent polymers being ethylcellulose (EC) as a more strongly hydrophobic and hydroxyethylcellulose (HEC) and / or hydroxypropyl methylcellulose (HPMC) as more strongly hydrophilic (the ratio of HEC to HPMC being between 1:100 and 100:1). The matrix tablet is optionally coated with an enteric coat, 0-5%-15% wt / wt to prevent the initial burst effect seen in such systems and to impart gastrointestinal tract (GIT) “stealth” characteristics especially in the presence of food.

A controlled release pharmaceutical composition comprises (a) topiramate or a pharmaceutically acceptable salt thereof, (b) a first intelligent polymer component; and (c) a second intelligent polymer component having opposite wettability characteristics to the first intelligent polymer component. The polymer components are effective for controlled release of the pharmaceutically active substance from the composition.

A method, apparatus and production well system that utilize stimulus-responsive materials for “conformance control” and profile control along the fluid flow path in a well as part of a gravel pack or a coating on a well tool. The stimulus-responsive materials are also known as intelligent or smart polymers and are typically polymeric materials that reversibly or irreversibly swell or collapse in the presence of stimulus such as changes in concentration of a fluid media in contact with the stimulus-responsive material, pH or polarity of the media the stimulus-responsive material is in contact with, salinity, current; or temperature. The stimulus-responsive materials may swell upon contact with a rust stimulus and shrink or collapse upon contact with a second stimulus or vice-versa The changes between production and injection profiles may be automatic with the application of the stimulus-responsive materials and may occur without user intervention.

The invention relates to a temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof. The microcapsule comprises two polymers sensitive to temperature and pH, and an interpenetrating network structure is formed between the two polymers. Preparation includes the following steps: (1) uniformly blending tetraethyl orthosilicate, aqueous ammonia, water and absolute ethyl alcohol, and then adding surface modifier; (2) adding temperature-sensitive monomer and crosslinking agent into the modified dispersion, and adding initiator for reaction; (3) after diluting the emulsion by five to fifteen times, adding pH-sensitive monomer and crosslinking agent, and adding initiator for reaction; and (4) dispersing the white emulsion of core-shell composite particles with shells formed into a interpenetrating polymer network structure into hydrofluoric acid, and carrying out centrifugal separation or dialysis purification. The microcapsule can respectively respond tothe stimulation of temperature and pH, and moreover, the two types of stimuli responsiveness are independent from each other, and therefore have little interference on each other. The preparation method is simple, and is suitable for industrial production.

The current invention is a novel superparamagnetic site-targeting nanoparticle comprising superparamagnetic nanoparticles encapsulated with a smart polymer. The superparamagnetic site-targeting nanoparticle comprises a functionalized superparamagnetic core that is conjugated with a therapeutic agent and then encapsulated with a smart polymer. The smart polymer can be any polymer that exhibits a reversible conformational or physio-chemical change in response to an external stimulus or stimuli.

The invention relates to a garment and a preparation method thereof, in particular to a carbon heating garment taking carbon conductive yarns as a heating element and a preparation method thereof. The outside of the rear piece of the carbon heating garment is provided with a pocket which is positioned near the lumbar vertebrae of a human body; and the pocket is provided with a carbon heating sheet sewn and packed by nano bamboo charcoal knitted fabric, connecting wires and intelligent polymer lithium battery pack; the carbon heating sheet is connected with the anode and the cathode of the lithium battery pack by the connecting wires; and the carbon heating sheet is compounded by pressing and rolling carbon conductive fabric with an environment friendly polyurethane thin film or vinyl acetate thin film. The garment has the advantages of fast heating and temperature rise, no odor, no pollution and good effect, and the garment is an ideal warm garment with heat supply function.

A smart polymer molded hybrid shipping container generally refers to large intermodal shipping container and their manufacture, and more particularly to a recyclable rotationally-molded RF (radio frequency) transparent thermoplastic polymer shell with a removable outer structural fabricated steel load bearing support frame capable of being integrated with an internally mounted geo-location detection system, date transmission communication devices, inner environmental sensors, data storage system, and power storage system. The smart polymer molded hybrid shipping container is designed to be 100% recyclable after useful life with a mechanically fastened exoskeleton steel frame that can be reused in the post manufacturing process. The smart polymer molded hybrid shipping container has a one piece molded shell with load bearing molded in floor system and outer polymer skin that is entirely weather resistant and non-corrosive.

Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and / or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral / basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.

The invention discloses a polymer nanometer blocking agent for water-based drilling fluid and its preparation method, and belongs to the technical field of a drilling fluid function material. The polymer nanometer blocking agent for water-based drilling fluid is prepared from, by weight, 4-16 parts of emulgator, 2-14 parts of temperature sensitive monomer, 10-53 parts of hydrophilic monomer, 0.5-10 parts of hydrophobic monomer and 0.05-0.5 part of initiator. The polymer nanometer blocking agent is small in size, and can block micro and nano-sized holes of a shale well wall; through compressivedeformation property of the poymer, the compact blocking of the well wall hole can be realized; by means of the temperature response property of an intelligent polymer, the transformation from hydrophilia to hydrophobicity is realized in the well wall, and the zone closing to the well wall is transformed to be a hydrophobic environment, thus the diffusion and permeation of water in the water-based dirlling fluid towards the shale well wall is effectively stopped, thereby stabilizing the well wall and protecting reservoir, and providing an important technical guarantee for the development of the water-based drilling fluid system for shale development.

The present invention provides a porous hollow silica micro- or nanoparticle with a polymer grafted thereon, wherein the polymer is selected from poly(methacrylic acid) and copolymers thereof. The polymer may be covalently linked to the silica particle via a bridging group. Provided is also a method of covalently coupling a poly(methacrylic acid) to a silica surface of a hollow silica particle. The method comprises contacting a silica surface of a hollow silica particle that carries amino functional or halogen functional groups with a poly(methacrylic acid) or a copolymer or a respective monomer thereof. The method further comprises allowing the carboxyl group of the monomer or the poly(methacrylic acid) and an amino functional group or a halogen functional group on the silica surface to undergo a coupling reaction, thereby covalently coupling the polymer to the silica surface.

The invention provides a preparation method of an intelligent polymer composite. The preparation method includes the steps that functionalized graphene is uniformly dispersed in an anhydrous polar organic solvent, isocyanate-terminated polyurethane with a diene synthesis reaction is added, a reaction is carried out for 4-10 h at 50-100 DEG C, and the intelligent polymer composite is obtained. Functionalized graphene is connected to a polymer material with covalent bonds, the effect of uniform dispersion is achieved, and the strength of the polymer is improved; meanwhile, the optothermal conversion property of graphene is utilized, infrared light serves as a stimulus, and the effect of directional fixed-point repair is achieved.

The invention discloses an intelligent high-safety lithium-on battery with a polymer skeleton. The intelligent high-safety lithium-on battery comprises a positive electrode, a negative electrode, a membrane and an electrolyte, wherein the positive electrode, the negative electrode and the membrane all contain positive-temperature temperature-sensitive polymer particles; the lithium-on battery can be reversibly converted between a ''liquid lithium-on battery'' and a ''polymer lithium-on battery'' within different temperature ranges; the electrolyte in the ''liquid lithium-on battery'' exists in a form of a liquid electrolyte; and the electrolyte in the ''polymer lithium-on battery'' exists in a form of a polymer electrolyte. The lithium-on battery disclosed by the invention is quickly converted into the ''polymer lithium-on battery'' when the temperature suddenly rises, and does not contain the liquid electrolyte, so that an unstable solid-liquid interface can be removed and the interface stability of the battery can be effectively improved; and by adopting the polymer skeleton, the positive electrode, the negative electrode and the membrane of the battery are tightly connected, and the stability of the battery structure can be improved, so that the lithium-on battery can show good cycling stability and excellent electrochemical properties at different temperatures and is suitable for various complicated environments.

The invention relates to a carbon heating scarf and a preparation method thereof. The carbon heating scarf is characterized by comprising a base cloth, a carbon heating sheet, agraffes, connecting wires and intelligent polymer lithium battery pack; the carbon heating sheet is compounded by pressing and rolling carbon conductive fabric with a environment friendly polyurethane thin film or vinyl acetate thin film, and sewn and packed by nano bamboo charcoal knitted fabric; the carbon heating sheet is connected with the intelligent polymer lithium battery pack and a thin film regulating switch in series by the connecting wires to form a circuit; the agraffes are respectively sewn in the middle part of the base cloth of the scarf and on one side of the nano bamboo charcoal fabric of the carbon heating sheet so as to bond each other. The scarf has the advantages of fast heating and temperature rise, no odor, no pollution and good heat preservation effect, and the scarf is an ideal warm scarf with heat supply function.

The name of the invention is conformance control through Stimulus-presponsive materials. The present invention describes a method, apparatus and production well system that utilize stimulus- responsive materials for 'conformance control' and profile control along the fluid flow path in a well as part of a gravel pack or a coating on a well tool. The stimulus- responsive materials are also known as intelligent or smart polymers and are typically polymeric materials that reversibly or irreversibly swell or collapse in the presence of stimulus such as changes in concentration of a fluid media in contact with the stimulus-responsive material, pH or polarity of the media the stimulus-responsive material is in contact with, salinity, current; or temperature. The stimulus-responsive materials may swell upon contact with a first stimulus and shrink or collapse upon contact with a second stimulus or vice-versa. The changes between production and injection profiles may be automatic with the application of the stimulus-responsive materials and may occur without user intervention.

A controlled release pharmaceutical composition comprises (a) topiramate or a pharmaceutically acceptable salt thereof, (b) a first intelligent polymer component; and (c) a second intelligent polymer component having opposite wettability characteristics to the first intelligent polymer component. The polymer components are effective for controlled release of the pharmaceutically active substance from the composition.

A viscous composition for transdermal drug delivery, a method of preparing the same, and a microstructure device prepared using the viscous composition are provided. Here, the viscous composition includes colloidal particles formed of a combination of a drug and a biodegradable polymer, and the biodegradable polymer includes a first amphiphilic polymer. The use of a solvent can be minimized to homogenize the drug in the biodegradable polymer including the first amphiphilic polymer, thereby forming colloidal particles. Therefore, since a separate solvent cannot be used, the microstructure device is expected to be a transdermal drug delivery system which is safe, efficient or useful for drugs which do not include a proper solvent, show poor bioavailability or have a high molecular weight.

The present invention provides a conjugate of tenofovir, addy adefovir and intelligent polymers, a method for preparing the same, and an usage. The invention relates to the technical field that antiviral medicinal molecular tenofovir and addy adefovir are chemical modified, namely, phosphate group of tenofovir or addy adefovir is linked with X group, then X group is linked with intelligent polymers R, or phosphate group of tenofovir or addy adefovir is linked with intelligent polymers R with X function group, and a conjugate of tenofovir, addy adefovir and intelligent polymers with A-X-R-Y formula is formed. The modified tenofovir and addy adefovir forms efficient screen for raw medicine, and improves obviously medicine absorption of intestinal and absorption of cell, improves bioavailability of medicine, at the same time, reduces the kidney cleaning of medicine, and reduces the toxic for kidney, improves security.

A system and a method for adaptively releasing a lubricant or a cosmetic for a razor cartridge, a sensing unit detects a property of at least one of skin, air, water and a chemical agent in a region adjacent to the razor cartridge. A smart polymer provided on the razor cartridge is selectively responsive to a characteristic external stimulus by undergoing a physical or chemical change. A processing unit controls the release of the lubricant or the cosmetic by providing the characteristic external stimulus to cause the smart polymer to undergo a change. The processing unit compares the detected property to a reference threshold parameter and determines whether to provide the characteristic external stimulus to the smart polymer based on the comparison, thereby generating the lubricant or the cosmetic. The determined level of depletion of the smart polymer is indicated by a light, aural, or haptic indication.

The invention relates to a multi-purpose carbon cushion and method for producing the same. The cushion is divided into an inner mat and an outer packaging, wherein, the inner mat includes carbon heating pieces, connecting wires, and intelligent polymer lithium batteries. The carbon heating pieces are formed by pressing an environmental-protecting type polyurethane or vinyl acetate film on the carbon conductive fabrics, and a nano-bamboo carbon knitting fabric is adopted to tailor and package; radial direction conductive filaments in the carbon heating piece adopt a paralleled connection mode,and then are connected to the anode and cathode of the polymer lithium batteries; and the outer layer packages of the carbon heating cushion is made of textiles into a bag shape. The present invention is an ideal heat supply and thermal protection cushion, which has advantages of fast heating up, tasteless, pollution-free, and widely application to legs, shoulders, stomach, waist, abdomen, etc.

The present invention corresponds to a method for the removal of unwanted phenolic compounds from foodstuffs, more particularly beverages. The method comprising contacting a selected polymer with the foodstuff. In a particular embodiment, the polymers are selected among polyaniline (PANI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers, or the polymers are selected among polyamidoamine (PAMAM) dendrimers functionalized with polyaniline (PANI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers.

The invention relates to a lactose-based intelligent polymer and application thereof. The lactose-based intelligent polymer is prepared by grafting aldehyde group of a lactose functional monomer to a main chain of a poly-amino polymer; the poly-amino polymer comprises a mixture of one or more of polyacrylamide, polyethyleneimine, poly-asparagine, polyamide, aminoethyl polymethacrylate, polyamide-amine and aminopropyl polymethacrylate. Polymer film material prepared from the lactose polymer is capable of responding to sialic acid adsorption and desorption dynamically and irreversibly, thereby exhibiting great change in the materials properties, such as surface wettability, hardness, and viscous force. These materials characteristics can promote the application of materials in the recognition and detection of sialic acid. Therefore, by grafting the lactose-based intelligent polymer to a porous inorganic medium, a chromatographic separation material is acquired which is capable of separating glycopeptides different in sugar chain structure, particularly sialoglycopeptide.

The invention discloses a photo-thermal patterned self-reinforced polymer material and a preparation method thereof, and belongs to the technical field of self-reinforced polymer materials. The photo-thermal patterned self-reinforced polymer material comprises the following raw materials: a monomer with a polymerized side chain containing an ester bond, an initiator, a photo-thermal conversion filler, an ester exchange reaction catalyst and a cross-linking agent. According to the present invention, the self-crosslinking polymerization reaction and the ester exchange reaction under the thermalor illumination condition are performed to obtain the polymer material capable of locally achieving the patterning self-enhancement, such that the same material has two different properties so as to meet the intelligent requirement on the material; and the preparation method of the polymer material is simple and easy to operate, the intelligent polymer material with different hardness degrees andspecific patterns can be obtained at the same time, practicability is high, and wide application prospects are achieved.

The invention relates to a carbon heating waistband and a preparation method thereof. The waistband comprises a lumbar support, a patch pocket, an elastic band, a fibula, a battery bag, a carbon heating piece, a connecting lead, and an intelligent polymer lithium battery; a warp direction static wire in the carbon heating piece adopts the parallel connection mode, and then is connected with the positive set and the negative set of the lithium battery; the elastic band is connected with the two ends of the waistband; the fibula is respectively connected with the two ends of the elastic band; the lumbar support are weaved by three layers of textile fabrics and forms two patch pockets; the internal layer patch pocket is close to the waist of human body, made of knitting fishnet and used for putting the heating element; the outer layer is made of woven fabric and used for putting flexible synthetic glass thin material according to the requirements; the battery bag is arranged at one end of the elastic band and can be adjusted according to the requirements. The waistband has the advantages of quick heating and warming, being odourless and pollution-free, good effect, and is an ideal heat supplying and insulation waistband.

A microfluidic movement control method utilizing light, a device, and a microtubule actuator (2). The microtubule actuator (2) is prepared by utilizing a light-induced deformed smart polymer material. The smart polymer material forms, by an exciting beam, asymmetrical deformation, and is induced to produce a capillary action to drive a microfluid movement. The embodiment can drive microfluids having various polarities and compositions, and can drive creep of the microfluid, and can even drive the microfluid to generate a 3D movement trail. The embodiment has found a wide range of potential applications in controllable microfluidic transport, micro-reaction systems, micro-mechanic systems, IC laboratories, and others.

The invention discloses an intelligent elastic bearing and a control method. The intelligent elastic bearing comprises an intelligent polymer material layer, a metal spacer layer and two joints, wherein one joint is used for connecting blades, and the other joint is used for connecting a propeller hub; and an external electric field or magnetic field is applied to the intelligent polymer materiallayer. According to the elastic bearing, a rubber material overlapped with a metal layer in a traditional elastic bearing is changed into an intelligent polymer material, and the novel elastic bearingwith the metal layer and the intelligent polymer material layer overlapped with each other is formed. Compared with a traditional elastic bearing made of a rubber material, in the working process ofa helicopter rotor system, the performance of the bearing can be controlled to be changed by changing physical parameters such as the external electric field and the magnetic field, and therefore active or semi-active vibration reduction of the helicopter rotor system is achieved.