49 results about "Hypertensive Nephropathy" patented technology

The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.

The invention provides a test paper for semi-quantitatively detecting colloid selenium in microdose albumin in urine. The test paper can be applied in the fields of early diagnosis of diabetic nephropathy, hypertensive nephropathy and preeclampsia and injury of kidney caused by various poisonous substances. A plastic bottom plate of the test paper is orderly glued with a sampling liquid absorption part, a colloid selenium labeling part, a detection reaction part and a water absorption part, wherein the colloid selenium labeling part is a single-cloning antibody 1 which is coated by a glass fiber membrane, or acetic acid fiber membrane, or nylon membrane and labeled by the colloid selenium; the detection reaction part is a nitrocellulose membrane which is provided with two detection bands and quality control bands, T1 is a single-cloning antibody 2 which is precisely quantitative, and T2 is the single-cloning antibody 2 with a certain concentration; and the quality control bands are coated by antiplague IgG. The invention provides a method for semi-quantitatively detecting the microdose albumin in a urine sample conveniently, visually and quickly.

The invention provides the usages of a drug composition comprising the active components of carvedilol and an angiotensin II receptor antagonist for preparing a drug which can cure nephropathy. The cooperation effect of the carvedilol and the angiotensin II receptor antagonist are used for developing a method which is more effective in curing the nephropathy. The drug composition has remarkable effects when being used for curing nephropathy, diabetic nephropathy, hypertensive nephropathy, and the like.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the following raw material medicines by weight: 6-40 parts of rheum officinale, 10-95 parts of astragalus and 5-65 parts of salvia miltiorrhiza by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

The invention belongs to the technical field of medicines, relates to a traditional Chinese medicinal composition and a preparation method of the composition, in particular to a traditional Chinese medicinal composition for treating diabetic nephropathy combined hypertensive nephropathy and a preparation method of the composition. The traditional Chinese medicinal composition aims to overcome the defects in the prior art that the chemotherapeutic drugs for treating the diabetic nephropathy combined hypertensive nephropathy is high in hepatotoxicity and poor in the curative effect. The traditional Chinese medicinal composition for treating diabetic nephropathy combined hypertensive nephropathy comprises the following components: 10-50 parts of herba epimedii, 10-20 parts of bark of eucommia, 5-20 parts of dried rehamnnia root, 5-15 parts of sealwort, 5-15 parts of the root of kudzu vine, 1-10 parts of ginseng, 5-15 parts of medlar, 9-15 parts of radix astragali, 9-15 parts of glossy privet fruit, 5-15 parts of platycodon grandiflorum, 1.5-9 parts of radix ophiopogonis, and 5.5-15 parts of pinellia ternate. The traditional Chinese medicinal composition can achieve a good curative effect for treating or preventing diabetic nephropathy combined hypertensive nephropathy, is low in side effect, and has an obvious clinical promotional value.

The invention discloses a medicine for treating chronic renal insufficiency and chronic renal failure diseases. The medicine comprises the following raw materials in parts by weight: 70-90 parts of hairy antler, 17-23 parts of prepared common monkshood daughter root, 70-90 parts of cassia twig and 170-230 parts of all-grass of desertliving cistanche; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of common macrocarpium fruit, 85-115 parts of prepared rhizome of rehmannia, 170-230 parts of largehead atractylodes rhizome, 170-230 parts of Chinese angelica and 45-55 parts of astragalus membranaceus; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of Indian buead, 170-230 parts of plantain seed and 17-23 parts of root-bark of tree peony; and preferably, the medicine also comprises the following raw materials in parts by weight: 85-115 parts of twotooth achyranthes root and 45-55 parts of rheum rhabarbarum. The medicine disclosed by the invention can be used for tonifying the kidney-qi, strengthening the kidney-yang and recovering the renal functions, and can be used for treating chronic renal insufficiency, chronic renal failure, limb weakness, waist-knee-limb coldness, difficult urination, frequent urination or nighttime micturition, bleak or dark complexion, sluggish in facial expression, double-limb pitting edema, face and eye edema, urea nitrogen increase, creatinine increase, hypertensive nephropathy and diabetic nephropathy caused by insufficiency of kidney-yang, and treating the chronic renal insufficiency and chronic renal failure diseases caused by medicine injury or other reasons.

The invention discloses a hypertensive nephropathy prediction method based on an incremental neural network model, comprising the following steps of: establishing a daily data database of hypertensive nephropathy; training a neural network model; collecting and transmitting daily life data to a server; extracting the current data from the daily data record table of a user to form the n-dimensional vector, and then normalizing and inputting the data into the neural network model of hypertensive nephropathy for predicting risk probability of hypertensive nephropathy. Whether the risk degree W of hypertensive nephropathy is greater than or equal to 3 is judged by the intelligent household hypertensive nephropathy nursing instrument; the user is reminded of having physical examination in hospital when receiving a warning alert, the examination results are transmitted back to the server through the intelligent household nephropathy nursing instrument, the server determines whether the examination results are correct or not. When the examination results are incorrect, the incremental algorithm is implemented and the neural network model is modified dynamically. The hypertensive nephropathy prediction method predicts accurately, and the neural network model is tailored to each user.

The invention provides methods and compositions for treating a subject having a renal-related disorder, such as chronic kidney disease (CKD), end stage renal failure, diabetes, insulin resistance, kidney hypertrophy, kidney hypotrophy, polycystic kidney disease, proteinuria, hyperglycemia, hyperuricemia, gout, kidney stones, hypertension or hypertensive nephropathy, dyslipidemia, anemia and / or reduced erythropoietin production, iron deficiency or hyperfiltration. The methods and compositions use or contain a composition that reduces or inhibits GDF15 activity.

The invention discloses a Chinese medicine composition for treating hypertensive nephropathy and a preparation method and application of the Chinese medicine composition. The Chinese medicine composition is prepared from the raw materials in parts by mass: 10-20 parts of rhizoma gastrodiae, 10-20 parts of uncaria rhynchophylla, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of herba epimedii, 20-40 parts of astragalus membranaceus, 20-40 parts of red-rooted salvia root, 20-40 parts of serissa serissoides and 6-15 parts of pinellia ternata. The preparation method specifically comprises the following steps of: weighing all Chinese medicinal herbs except for the uncaria rhynchophylla according to a proportion; adding water for decocting and extracting at a first time; then adding the uncaria rhynchophylla; adding water for decocting and extracting at a second time; and mixing two decoction extraction solutions, filtering, concentrating, centrifuging, and drying to prepare a dry extract. Clinical experiments indicate that the Chinese medicine composition has the functions of remarkably improving clinical symptoms of a patient suffering from hypertensive nephropathy, reducing blood pressure, blood beta2-M and 24h urine protein content, and improving hypohemia and kidney function, and can be expected to be used for preparing medicine preparations for treating the hypertensive nephropathy, and has an officinal prospect.

The invention belongs to the technical field of medicine, and particularly relates to application of a medicine composition in preparing medicine curing hypertensive nephropathy. The medicine composition comprises the following components: 10-24 parts of pseudostellaria heterophylla, 16-32 parts of hoantchy root, 12-18 parts of dwarf lilyturf turber, 13-29 parts of fragrant solomonseal rhizome, 8-16 parts of ginseng rootlet, 15-30 parts of lily, 8-16 parts of radices trichosanthis, 15-30 parts of dendrobe, 9-17 parts of spreading hedyotis herb, and 20-30 parts of liquorice. The medicine composition is a Chinese herbal medicine, has the function of reducing blood pressure, conforms to hypertension nephropathy medicine indication, and is remarkable in curative effect.

The invention relates to a pure traditional Chinese medicine preparation for treating glomerular diseases. The pure traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 30 parts of membranous milkvetch root, 12 parts of amur corktree bark, 15 parts of rhubarb, 40 parts of glabrous greenbrier rhizome, 20 parts of radix salviae miltiorrhizae, 15 parts of oriental waterplantain rhizome, 20 parts of epimedium herb, 15 parts of lalang grass rhizome and 30 parts of motherwort herb, and prepared by decoction, filtration, concentration of filtrate and drying. The pure traditional Chinese medicine preparation has significant efficacy for kidney diseases comprising acute and chronic glomerulonephritis, nephrotic syndrome, hypertensive nephropathy, diabetic nephropathy and early renal insufficiency caused by various reasons; furthermore, the raw materials are easily available, the production process is simple, the toxicity and side effects are small, and the administration is convenient, thereby providing the effective pure traditional Chinese medicine preparation for treating the kidney diseases.

The invention belongs to the field of medicine, in particular to a new application of human urinary kallidinogenase and a pharmaceutical composition with the human urinary kallidinogenase. According to the new application of the human urinary kallidinogenase, the human urinary kallidinogenase is used for preparing medicine for treating hypertensive nephropathy, and the test discovers that the human urinary kallidinogenase is capable of lowering the arterial pressure of a rat with hypertensive nephropathy and improving the glomerular filtration rate and renal plasma flow of the rat with hypertensive nephropathy through regulating the micro-circulation of glomerulus, and has a certain treatment effect for renal damage. The pharmaceutical composition for treating the hypertensive nephropathy comprises the human urinary kallidinogenase and betahistine hydrochloride and further comprises pentoxifylline, the pharmaceutical composition has an obvious blood pressure reducing efficiency and has an obvious treatment effect for the damaged kidney, and the pharmaceutical composition for treating the hypertensive nephropathy is definite in effect, low in side effect and better for the recovery of a patient with hypertensive nephropathy.

The invention relates to a medicine composition containing parietic acid and a pharmaceutical purpose of the medicine composition. The composition comprises the parietic acid and rheum emodin and can also comprise chrysophanol and emodin monomethyl ether. The composition can be made into preparations in a solid form, a liquid form, a gas form or a semi-solid form. A great number of experiments prove that the medicine composition can be used for treating kidney diseases, nephrotic syndrome, hypertensive nephropathy, cardiovascular and cerebrovascular diseases, tumor diseases and the like.

The invention belongs to the technical field of nephropathy prediction, and discloses a hypertensive nephropathy prediction system and method based on an incremental neural network model. The hypertensive nephropathy prediction system based on the incremental neural network model comprises a kidney image acquisition module, a blood pressure acquisition module, a urine protein acquisition module, amain control module, an image enhancement module, an image feature extraction module, an index comparison module, a disease analysis module, a disease prediction module, a screening module, a nephropathy supervision module, a cloud storage module and a display module. According to the invention, through the screening module, the screening efficiency of the hypertensive nephropathy is improved; and through the nephropathy supervision module, a patient can be treated according to a hypertensive nephropathy management scheme suitable for himself / herself, potential hypertensive nephropathy patients can be screened out as early as possible, and a reasonable management scheme is provided for the potential hypertensive nephropathy patients in time, so that the requirements for reducing the increasing speed of the number of the hypertensive nephropathy patients and relieving the burden of medical insurance funds are met.

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and genipin and application thereof. The composition containing pinoresinol diglucoside and genipin is prepared from the following components: pinoresinol diglucoside, genipin, nicotinamide, quercetin, a radix achyranthis bidentatae extract, tartronic acid and citric acid. The composition is simple in preparation method, can be used for treating hypertensive nephropathy, has a good curative effect, and can reduce side effects and reduce cost.

The invention belongs to the technical field of research and development of traditional Chinese medicines, and in particular discloses a traditional Chinese medicine for treating hypertensive nephropathy and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for treating the hypertensive nephropathy is prepared from the following raw materials in parts by weight: 15-21 parts of fossil fragments, 20-30 parts of concha ostreae, 13-21 parts of concha haliotidis, 9-15 parts of rhizoma gastrodiae, 18-25 parts of magnetite, 6-9 parts of alpine cladonia, 14-20 parts of salsola collina pall, 9-15 parts of royal poinciana, 7-10 parts of anaphalis lactea, 20-25 parts of eucommia bark, 9-15 parts of radix achyranthis bidentatae, 6-9 parts of mirabilite, 10-18 parts of fruit of Chinese magnoliavine, 13-18 parts of tuber fleeceflower stem, 9-16 parts of poria and 6-12 parts of herba leonuri. The traditional Chinese medicinal preparation for treating the hypertensive nephropathy provided by the invention is a drink which is capable of clearing heat, eliminating phlegm and reducing pressure; the traditional Chinese medicinal preparation is original and unique in formula, simple in composition, not expensive in various medicinal materials, low in overall cost, good in curative effect, free from toxic and side effects and free from tolerance; and the traditional Chinese medicinal preparation is quite suitable to be carried and taken by patients with the hypertensive nephropathy.

The invention relates to a medicated diet composition for pregnant women and a preparation method thereof. On the basis of iodine salt, the medicated diet composition for pregnant women is added with red dates, tuckahoe, Chinese yam, tangerine peel, lemon and lentinus edodes in an appropriate proportion, and under the synergetic effect of the components, the medicated diet composition has the health care efficacies of invigorating qi, nourishing blood, strengthening spleen, regulating the flow of qi, harmonizing stomach and preventing miscarriage. The medicated diet composition for pregnant women disclosed by the invention can effectively avoid the problems of hypertension, nephropathy, cardiovascular disease and the like easily caused by long-term consumption of common table salt in the prior art, has the health care efficacies of invigorating qi, nourishing blood, strengthening spleen, regulating the flow of qi, harmonizing stomach and preventing miscarriage, is particularly suitable for daily health care diet of pregnant women, and conforms to the need of modern health diet.

The invention discloses a medicinal composition for treating hypertensive nephropathy. The medicinal composition is composed of the following ingredients: fructus chebulae, fructus gardeniae, fructustoosendan, flos carthami, folium eriobotryae, lacca, radix aconiti kusnezoffii, resin commiphorae muakulis(guggulum), fructus amomi rotundus, white soybeans, all-grass of oxytropis myriophylla, and the like. The medicinal composition provided by the invention can obviously reduce urine protein and urine microalbumin, and has the total effective rate achieving 90% when used for treating proteinuria, after 24h of treatment for urine protein, urine microalbumin, serum creatinine, urea nitrogen, blood and urine beta2-MG, the result shows that the medicinal composition has the obvious efficiency intreating hypertensive nephropathy, and can obviously improve proteinuria, and protect the kidney function.

The invention provides applications of Shenkang injection in medicine used for treatment of hypertensive nephropathy. The injection comprises following bulk drugs, by weight: 7 to 15 portions of rheum officinale, 6 to 15 portions of red sage root, 8 to 15 portions of carthamus tinctorius and 15 to 45 portions of radix astragali. It is confirmed by experiments that: the Shenkang injection may help to decrease blood pressure, and the content of urinary albumin microspheres, serum creatinine and urea nitrogen of rats with hypertensive nephropathy substantially; and may also help to improve renal blood flow of rats with hypertensive nephropathy, and adjust nitric oxide and endothelin levels. Pathologic results show that the Shenkang injection may improve and suppress damages of kidneys caused by hypertension. The Shenkang injection has substantial effects for treatment of hypertensive nephropathy.

The invention belongs to the technical field of traditional Chinese medicine research and development and particularly relates to a traditional Chinese medicine preparation for treating hypertensive nephropathy and a preparing method thereof. The traditional Chinese medicine preparation is prepared from, by weight, 8-13 parts of dried radix rehmanniae, 10-15 parts of bulbus fritillariae cirrhosae, 6-9 parts of purple perilla, 7-15 parts of saposhnikovia divaricata, 7-14 parts of radix isatidis, 9-15 parts of Chinese yam, 13-18 parts of semen cuscutae, 5-9 parts of radix aconite carmichaeli, 9-15 parts of semen coicis, 6-12 parts of folium mori, 6-12 parts of houttuynia cordata, 6-9 parts of cicada slough, 6-12 parts of Buddleja officinalis, 10-15 parts of cortex fraxini, 13-21 parts of veined inula root, 10-18 parts of gaultheria yunnanensis and 5-15 parts of begonia fimbristipula. The traditional Chinese medicine preparation for treating the hypertensive nephropathy is a heat-clearing, phlegm-reducing and antihypertensive decoction and is novel and unique in formula, simple in composition, low in medicinal material price and overall cost, good in curative effect, free of toxic and side effects, less prone to tolerance and quite suitable for hypertensive nephropathy patients to carry and take.

The invention relates to a pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and a pharmaceutical application thereof. The composition contains total anthraquinone in rheum, total salvianolic acids and / or carthamin, wherein total anthraquinone in rheum can be replaced with rheum emodin and / or rheinic acid; total salvianolic acids can be replaced with salvianolic acid B and / or tanshinol; and carthamin can be replaced with hydroxysafflor yellow A. The composition can also contain chrysophanol and emodin monomethyl ether, or rhubarb polysaccharide, or salvianolic acid A. The composition can be made into a solid, liquid, gaseous or semisolid preparation. Lots of experiments confirm that the pharmaceutical composition can be used in treating kidney disease, hypertensive nephropathy, cardiovascular and cerebrovascular diseases and tumour disease, etc.

The invention relates to special health steamed bread for chronic kidney diseases and belongs to the technical field of clinical nutritious foods. The special health steamed bread for the chronic kidney diseases comprises the following raw materials: 10 parts of wheat meal, 55-65 parts of starch, 4-8 parts of soluble dietary fibers, 10-15 parts of buckwheat meal and 10-15 parts of pearl barley powder, wherein the total amount of the buckwheat meal and the pearl barley powder is 20-25 parts. According to the special health steamed bread, the ratios of the wheat meal, the starch and the soluble dietary fibers are adjusted; and meanwhile, the buckwheat meal and the pearl barley powder, which are compounded according to the specific ratio, are added to prepare the special health steamed bread for the chronic kidney diseases, which has abundant nutritional ingredients and has the effects of improving the mouth feel, reducing the protein content and lowering the glucose improving index is prepared through adjusting the ratios of the wheat meal, the starch and the soluble dietary fibers and adding the buckwheat meal and the pearl barley powder which are compounded according to the specific ratio. The blood glucose and blood pressure can be effectively controlled after people eat the steamed bread for a long period, the development of CKD including diabetic nephropathy and hypertensive nephropathy, caused by a plurality of etiological factors, is delayed, and the health effect is good.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale, astragalus and safflower with a weight ratio of 3-45:9-85:3-65 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

The invention provides the usages of a drug composition comprising the active components of carvedilol and an angiotensin II receptor antagonist for preparing a drug which can cure nephropathy. The cooperation effect of the carvedilol and the angiotensin II receptor antagonist are used for developing a method which is more effective in curing the nephropathy. The drug composition has remarkable effects when being used for curing nephropathy, diabetic nephropathy, hypertensive nephropathy, and the like.

The invention provides a test paper for semi-quantitatively detecting colloid selenium in microdose albumin in urine. The test paper can be applied in the fields of early diagnosis of diabetic nephropathy, hypertensive nephropathy and preeclampsia and injury of kidney caused by various poisonous substances. A plastic bottom plate of the test paper is orderly glued with a sampling liquid absorption part, a colloid selenium labeling part, a detection reaction part and a water absorption part, wherein the colloid selenium labeling part is a single-cloning antibody 1 which is coated by a glass fiber membrane, or acetic acid fiber membrane, or nylon membrane and labeled by the colloid selenium; the detection reaction part is a nitrocellulose membrane which is provided with two detection bands and quality control bands, T1 is a single-cloning antibody 2 which is precisely quantitative, and T2 is the single-cloning antibody 2 with a certain concentration; and the quality control bands are coated by antiplague IgG. The invention provides a method for semi-quantitatively detecting the microdose albumin in a urine sample conveniently, visually and quickly.

The invention relates to a pharmaceutical composition containing calycosin and a pharmaceutical application thereof. The composition contains calycosin, astragaloside and / or astragalus polysaccharide. The composition can be made into a solid, liquid, gaseous or semisolid preparation. Lots of experiments confirm that the pharmaceutical composition can be used in treating kidney disease, chronic renal failure, nephritis, hypertensive nephropathy, cardiovascular and cerebrovascular diseases and tumor diseases, etc.

The invention discloses a medicine for treating chronic renal insufficiency and chronic renal failure diseases. The medicine comprises the following raw materials in parts by weight: 70-90 parts of hairy antler, 17-23 parts of prepared common monkshood daughter root, 70-90 parts of cassia twig and 170-230 parts of all-grass of desertliving cistanche; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of common macrocarpium fruit, 85-115 parts of prepared rhizome of rehmannia, 170-230 parts of largehead atractylodes rhizome, 170-230 parts of Chinese angelica and 45-55 parts of astragalus membranaceus; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of Indian buead, 170-230 parts of plantain seed and 17-23 parts of root-bark of tree peony; and preferably, the medicine also comprises the following raw materials in parts by weight: 85-115 parts of twotooth achyranthes root and 45-55 parts of rheum rhabarbarum. The medicine disclosed by the invention can be used for tonifying the kidney-qi, strengthening the kidney-yang and recovering the renal functions, and can be used for treating chronic renal insufficiency, chronic renal failure, limb weakness, waist-knee-limb coldness, difficult urination, frequent urination or nighttime micturition, bleak or dark complexion, sluggish in facial expression, double-limb pitting edema, face and eye edema, urea nitrogen increase, creatinine increase, hypertensive nephropathy and diabetic nephropathy caused by insufficiency of kidney-yang, and treating the chronic renal insufficiency and chronic renal failure diseases caused by medicine injury or other reasons.

The invention discloses a medicinal composition for treating hypertensive nephropathy. The medicinal composition is composed of the following ingredients: fructus chebulae, fructus gardeniae, fructustoosendan, flos carthami, folium eriobotryae, lacca, radix aconiti kusnezoffii, resin commiphorae muakulis(guggulum), fructus amomi rotundus, white soybeans, all-grass of oxytropis myriophylla, and the like. The medicinal composition provided by the invention can obviously reduce urine protein and urine microalbumin, and has the total effective rate achieving 90% when used for treating proteinuria, after 24h of treatment for urine protein, urine microalbumin, serum creatinine, urea nitrogen, blood and urine beta2-MG, the result shows that the medicinal composition has the obvious efficiency intreating hypertensive nephropathy, and can obviously improve proteinuria, and protect the kidney function.