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Pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and pharmaceutical application thereof

A technology of total anthraquinones of rhubarb and total salvianolic acids, which is applied in the field of medicine and can solve problems such as the absence of emodin

Inactive Publication Date: 2015-10-28
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there have been researches on the efficacy of the above-mentioned single ingredients or simple combinations at home and abroad, there is no combination of rhubarb total anthraquinones, salvianolic acids and safflower glycosides containing definite doses for the treatment of kidney disease and other diseases. There are no reports on the combination of emodin, rhein, salvianolic acid B, danshensu and hydroxysafflower yellow A with rhubarb total anthraquinone, salvianolic acid and safflower glycosides in the treatment of kidney diseases

Method used

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  • Pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and pharmaceutical application thereof
  • Pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and pharmaceutical application thereof
  • Pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and pharmaceutical application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0162] Take 2.5g total anthraquinones of rhubarb and 2.6g total phenolic acids of salvia miltiorrhiza, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5-7.0, add water for injection to dilute to 1000ml, filter with 0.22μm microporous membrane, aliquot and sterilize to obtain injection.

Embodiment 2

[0164] Take 2.5g total anthraquinones of rhubarb and 2.5g safflower glycosides, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5-7.0, add water for injection to dilute to 1000ml , filtered through a 0.22 μm microporous membrane, subpackaged, and sterilized to obtain an injection.

Embodiment 3

[0166] Take 250g total anthraquinones of rhubarb, 260g total salvianolic acid, 2.6g safflower glycosides, appropriate amount of meglumine and arginine, add water for injection and dilute to 5L, stir until dissolved, filter, and adjust the pH value of the filtrate to 5.0-7.0 , use a 0.22μm microporous membrane for fine filtration; take an appropriate amount of mannitol and add water for injection to prepare a solution, mix with the above filtrate, filter through a 0.22μm microporous membrane, add water for injection to dilute to 10L, and prepare 10ml as a unit The dosage is subpackaged, freeze-dried, and freeze-dried powder is obtained.

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Abstract

The invention relates to a pharmaceutical composition containing total anthraquinone in rheum and total salvianolic acids and a pharmaceutical application thereof. The composition contains total anthraquinone in rheum, total salvianolic acids and / or carthamin, wherein total anthraquinone in rheum can be replaced with rheum emodin and / or rheinic acid; total salvianolic acids can be replaced with salvianolic acid B and / or tanshinol; and carthamin can be replaced with hydroxysafflor yellow A. The composition can also contain chrysophanol and emodin monomethyl ether, or rhubarb polysaccharide, or salvianolic acid A. The composition can be made into a solid, liquid, gaseous or semisolid preparation. Lots of experiments confirm that the pharmaceutical composition can be used in treating kidney disease, hypertensive nephropathy, cardiovascular and cerebrovascular diseases and tumour disease, etc.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing total anthraquinones of rhubarb and total salvianolic acids for treating kidney diseases and an application thereof. Background technique [0002] The total anthraquinones of rhubarb are brown-black extracts or brown powder crystals, which are the main extraction parts of rhubarb medicinal materials, including free anthraquinones, combined anthraquinones, anthrone, sugar, tannins, etc. It has been reported in the literature that it has pharmacological effects such as diarrhea. Rhein belongs to monoanthracene nuclear 1,8-dihydroxyanthraquinone derivatives, brown needle crystals, insoluble in water, soluble in pyridine and sodium bicarbonate aqueous solution, slightly soluble in ethanol, benzene, chloroform, ether and petroleum ether, Molecular formula C15H8O6. In recent years, studies have found that rhein has a wide range of pharmacolog...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K36/537A61K31/7034A61K31/351A61K31/715A61P13/12A61P9/12A61P35/00A61P9/00A61P9/10A61K31/343A61K31/192A61K31/122
Inventor 吴芳吕延英王光建赵兴詹芳王俊平贾诚曾艳龙
Owner XIAN SHIJISHENGKANG PHARMA IND
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