47 results about "Hypertensive kidney disease" patented technology

The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.

The invention provides methods and compositions for treating a subject having a renal-related disorder, such as chronic kidney disease (CKD), end stage renal failure, diabetes, insulin resistance, kidney hypertrophy, kidney hypotrophy, polycystic kidney disease, proteinuria, hyperglycemia, hyperuricemia, gout, kidney stones, hypertension or hypertensive nephropathy, dyslipidemia, anemia and / or reduced erythropoietin production, iron deficiency or hyperfiltration. The methods and compositions use or contain a composition that reduces or inhibits GDF15 activity.

The invention provides a test paper for semi-quantitatively detecting colloid selenium in microdose albumin in urine. The test paper can be applied in the fields of early diagnosis of diabetic nephropathy, hypertensive nephropathy and preeclampsia and injury of kidney caused by various poisonous substances. A plastic bottom plate of the test paper is orderly glued with a sampling liquid absorption part, a colloid selenium labeling part, a detection reaction part and a water absorption part, wherein the colloid selenium labeling part is a single-cloning antibody 1 which is coated by a glass fiber membrane, or acetic acid fiber membrane, or nylon membrane and labeled by the colloid selenium; the detection reaction part is a nitrocellulose membrane which is provided with two detection bands and quality control bands, T1 is a single-cloning antibody 2 which is precisely quantitative, and T2 is the single-cloning antibody 2 with a certain concentration; and the quality control bands are coated by antiplague IgG. The invention provides a method for semi-quantitatively detecting the microdose albumin in a urine sample conveniently, visually and quickly.

The invention discloses a medicine for treating chronic renal insufficiency and chronic renal failure diseases. The medicine comprises the following raw materials in parts by weight: 70-90 parts of hairy antler, 17-23 parts of prepared common monkshood daughter root, 70-90 parts of cassia twig and 170-230 parts of all-grass of desertliving cistanche; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of common macrocarpium fruit, 85-115 parts of prepared rhizome of rehmannia, 170-230 parts of largehead atractylodes rhizome, 170-230 parts of Chinese angelica and 45-55 parts of astragalus membranaceus; preferably, the medicine also comprises the following raw materials in parts by weight: 170-230 parts of Indian buead, 170-230 parts of plantain seed and 17-23 parts of root-bark of tree peony; and preferably, the medicine also comprises the following raw materials in parts by weight: 85-115 parts of twotooth achyranthes root and 45-55 parts of rheum rhabarbarum. The medicine disclosed by the invention can be used for tonifying the kidney-qi, strengthening the kidney-yang and recovering the renal functions, and can be used for treating chronic renal insufficiency, chronic renal failure, limb weakness, waist-knee-limb coldness, difficult urination, frequent urination or nighttime micturition, bleak or dark complexion, sluggish in facial expression, double-limb pitting edema, face and eye edema, urea nitrogen increase, creatinine increase, hypertensive nephropathy and diabetic nephropathy caused by insufficiency of kidney-yang, and treating the chronic renal insufficiency and chronic renal failure diseases caused by medicine injury or other reasons.

The invention discloses a medicinal composition for treating hypertensive nephropathy. The medicinal composition is composed of the following ingredients: fructus chebulae, fructus gardeniae, fructustoosendan, flos carthami, folium eriobotryae, lacca, radix aconiti kusnezoffii, resin commiphorae muakulis(guggulum), fructus amomi rotundus, white soybeans, all-grass of oxytropis myriophylla, and the like. The medicinal composition provided by the invention can obviously reduce urine protein and urine microalbumin, and has the total effective rate achieving 90% when used for treating proteinuria, after 24h of treatment for urine protein, urine microalbumin, serum creatinine, urea nitrogen, blood and urine beta2-MG, the result shows that the medicinal composition has the obvious efficiency intreating hypertensive nephropathy, and can obviously improve proteinuria, and protect the kidney function.

The present invention relates to the application of Morinda, in particular to the application of Morinda in the preparation of medicines for preventing and treating hypertension and / or nephropathy. The nephropathy is nephropathy caused by essential hypertension or nephropathy caused by other reasons. The inventors of the present invention have found through a large number of experiments that Morinda can prevent and treat hypertension as well as nephropathy. In particular, it has been verified on SHR hypertensive nephropathy model rats that the drug can effectively prevent and treat hypertensive nephropathy.