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Traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use

A chronic kidney disease and composition technology, which is applied in the direction of drug combination, pharmaceutical formula, urinary system diseases, etc., can solve the problems of high cost, complicated preparation process, and low extraction rate of active ingredients

Inactive Publication Date: 2014-07-02
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the prior art discloses the combined use of rhubarb and astragalus to treat chronic kidney disease and chronic renal failure, their preparation techniques often have problems such as complex procedures, high cost, and low extraction rate of active ingredients.

Method used

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  • Traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0145] (1) Take 1300g of safflower and 900g of rhubarb crushed into coarse particles, add 10 times the amount of water to soak for 20 minutes, heat and ultrasonically extract for 20 minutes for the first time, filter; heat and ultrasonically extract for 10 minutes for the second time, filter and combine twice Water extract, concentrated under reduced pressure to a relative density of 1.21 at 60°C, added 5% gelatin solution to remove tannin, filtered, added ethanol to make the alcohol content to 75%, stood still, filtered, took the filtrate and concentrated under reduced pressure to a relative density At 1.21 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content 80%, let it stand, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, and then add 0.3%-0.5% activated carbon , boiled for 30 minutes, filtered, and adjusted to a pH value of 7.4-7.7 to obtain rhubarb and safflower extracts, and set aside;

[0146] (2) ...

Embodiment 2

[0149] (1) Take 1300g of safflower and 900g of rhubarb crushed into coarse particles, add 6 times the amount of water to decoct, combine the extracts, filter, collect the filtrate, concentrate, enter the macroporous resin column for adsorption and separation, and collect the first effluent; Elute with water, collect the eluate, then elute with 50%-60% ethanol, collect the ethanol eluate, recover the ethanol until it has no alcohol smell, combine the effluent, concentrate under reduced pressure to a relative density of 1.21 at 60°C, add 5% gelatin solution to remove tannin, filter, add ethanol to make the alcohol content to 75%, stand still, filter, take the filtrate and concentrate it under reduced pressure to a relative density of 1.21 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content to 80%, stand still, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, then add 0.3%-0.5% activated carbon, boil for 30m...

Embodiment 3

[0153] (1) Take 1300g of safflower and 900g of rhubarb crushed into fine particles and put them in the extraction kettle for CO 2 Supercritical extraction, the flow rate of the supercritical fluid entering the extraction kettle is 40L / h, the extraction pressure is 25MPa, the extraction temperature is 45°C, and the extraction time is 2.5h. The rhubarb and safflower high-pressure fluids flowing out of the extraction kettle enter the separation kettle Separation, separation pressure I is 8 Mpa, separation temperature I is 30 ° C; separation pressure II is 6 Mpa, separation temperature II is 25 ° C, collect the extracts of rhubarb and safflower, add water for injection to 2-3 Double the amount, then add 0.3%-0.5% activated carbon, boil for 30 minutes, filter, adjust the pH value to 7.4-7.7, and obtain rhubarb and safflower extracts, set aside;

[0154] (2) Take 1400g of astragalus and crush it into fine particles, mix it with 80% ethanol, put it in the extraction kettle for CO 2 ...

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Abstract

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale, astragalus and safflower with a weight ratio of 3-45:9-85:3-65 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicine for treating chronic kidney disease and chronic renal failure and a preparation method thereof. Specifically, it belongs to the field of medicine. Background technique [0002] Chronic Kidney Disease (CKD) clinically includes chronic glomerulonephritis, nephrotic syndrome, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy and various secondary nephropathy, etc. The prevalence of vascular disease is high and the mortality rate is high. In addition, the awareness rate of chronic kidney disease is low, the prevention rate is low, and the awareness rate of cardiovascular disease is low. It has become a global public health problem. Diagnosis of CKD is mainly based on two aspects: (1) kidney damage (displaying renal structural and functional abnormalities) for ≥ 3 months, with or without decreased glomerular filtration rate (GRF); (2) renal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/19A61P13/12
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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