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Applications of Shenkang injection in preparation of medicine used for treatment of hypertensive nephropathy

A technology for Shenkang injection and hypertensive nephropathy, which is applied in the directions of drug delivery, drug combination, cardiovascular system diseases, etc., can solve problems such as insufficient blood pressure, and should protect the kidneys while reducing blood pressure.

Active Publication Date: 2013-09-11
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been confirmed that effective control of blood pressure can delay the progress of kidney damage, but the clinical effect of simply using antihypertensive drugs to protect kidney function is far from enough. The kidney should be protected while reducing blood pressure.

Method used

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  • Applications of Shenkang injection in preparation of medicine used for treatment of hypertensive nephropathy
  • Applications of Shenkang injection in preparation of medicine used for treatment of hypertensive nephropathy
  • Applications of Shenkang injection in preparation of medicine used for treatment of hypertensive nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Take 1,000 g of rhubarb and 1,200 g of danshen, extract them with water three times, combine the water extracts, concentrate and undergo alcohol precipitation and gelatin detanning twice, take the supernatant, filter and clarify, recover ethanol, add water for injection, refrigerate, Concentrate the supernatant, add 95% ethanol, let it stand, recover the ethanol, add water for injection again; take the supernatant, add activated carbon, adjust the pH value, and sterilize to obtain rhubarb and salvia miltiorrhiza extracts, set aside; take 1200g of safflower 3000g of Radix Astragali, after 3 times of water extraction, combined the water extract, concentrated, after 2 times of alcohol precipitation, recovered ethanol, added water for injection again, refrigerated, took the supernatant, added activated carbon, filtered, refrigerated, adjusted pH value, Sterilize to obtain safflower and astragalus extracts, and set aside; combine the above-mentioned rhubarb and salv...

Embodiment 2

[0012] The raw material medicine is composed of: rhubarb 1500g, salvia miltiorrhiza 1000g, safflower 1000g, astragalus 2000g, and the preparation method is the same as that in Example 1.

Embodiment 3

[0014] The raw material medicine is composed of: rhubarb 800g, salvia miltiorrhiza 1500g, safflower 800g, astragalus 4000g, and the preparation method is the same as that in Example 1.

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PUM

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Abstract

The invention provides applications of Shenkang injection in medicine used for treatment of hypertensive nephropathy. The injection comprises following bulk drugs, by weight: 7 to 15 portions of rheum officinale, 6 to 15 portions of red sage root, 8 to 15 portions of carthamus tinctorius and 15 to 45 portions of radix astragali. It is confirmed by experiments that: the Shenkang injection may help to decrease blood pressure, and the content of urinary albumin microspheres, serum creatinine and urea nitrogen of rats with hypertensive nephropathy substantially; and may also help to improve renal blood flow of rats with hypertensive nephropathy, and adjust nitric oxide and endothelin levels. Pathologic results show that the Shenkang injection may improve and suppress damages of kidneys caused by hypertension. The Shenkang injection has substantial effects for treatment of hypertensive nephropathy.

Description

technical field [0001] The invention relates to a new application of Shenkang injection, in particular to the application of Shenkang injection in the preparation of medicines for treating hypertensive nephropathy, and belongs to the field of pharmaceutical applications. Background technique [0002] Hypertensive nephropathy is a common disease caused by essential hypertension, and it is also a common and frequently-occurring disease in clinical practice. Generally, organic lesions of the kidney will appear after 5-10 years of hypertension. Multi-risk factor intervention research data show that as the blood pressure grade increases, the incidence of end-stage renal disease (ESRD) increases significantly. Individuals with high blood pressure (135 / 85mmHg) have a higher risk of end-stage renal failure than normal blood pressure ( 120 / 80mmHg) individuals are twice as high; severe hypertension (≥180 / 110mmHg) patients, the risk of end-stage renal failure is 12 times higher than no...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/08A61P9/12A61P13/12
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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