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Chinese medicine composition for treating hypertensive nephropathy and preparation method and application of Chinese medicine composition

A technology for hypertensive nephropathy and composition, applied in the field of traditional Chinese medicine, can solve problems such as limited curative effect

Inactive Publication Date: 2013-03-27
上海交通大学医学院附属新华医院崇明分院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medical treatment of hypertensive nephropathy is quite difficult. At present, Western medicine mainly uses angiotensin converting enzyme inhibitors and calcium ion antagonists, etc., and the curative effect is limited.

Method used

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  • Chinese medicine composition for treating hypertensive nephropathy and preparation method and application of Chinese medicine composition
  • Chinese medicine composition for treating hypertensive nephropathy and preparation method and application of Chinese medicine composition
  • Chinese medicine composition for treating hypertensive nephropathy and preparation method and application of Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 150g Gastrodia elata, 150g Achyranthes bidentata, 150g fairy spleen, 300g astragalus, 300g salvia miltiorrhiza, 300g Liuyuexue, 90g pinellia chinensis, add 19.08L water to decoct to extract, decoct for 0.5 hours, add 150g of Uncaria vine, continue to decoct Boil for 0.5 hours: add the same amount of water again for the second decoction, and decoct for 1 hour; combine the extracts from the two decoctions, filter, and concentrate until the relative density at 20°C is 1.059; centrifuge at 3000r / min for 4 minutes; Spray drying at 80°C to obtain a dry extract.

Embodiment 2

[0022] Weigh 100g Gastrodia elata, 200g Achyranthes bidentata, 200g fairy spleen, 200g astragalus root, 200g salvia miltiorrhiza, 200g Liuyuexue, 60g Pinellia chinensis, add 12.6L water to decoct to extract, decoct for 0.25 hours, add 100g of Uncaria vine, continue to decoct Boil for 0.25 hours: add the same amount of water again for the second decoction, and decoct for 0.5 hours; combine the extracts from the two decoctions, filter, and concentrate until the relative density at 20°C is 1.0; centrifuge at 3000r / min; ℃ spray drying to obtain dry extract.

Embodiment 3

[0024] Weigh 200g Gastrodia elata, 200g Achyranthes bidentata, 200g fairy spleen, 200g astragalus root, 200g salvia miltiorrhiza, 200g Liuyuexue, 150g pinellia chinensis, add 21.7L water to decoct to extract, decoct for 1 hour, add 200g of Uncaria vine, continue to decoct Boil for 1 hour: Add the same amount of water again for the second decoction, and decoct for 2 hours; combine the extracts from the two decoctions, filter, and concentrate until the relative density at 20°C is 1.2; centrifuge at 3000r / min; ℃ spray drying to obtain dry extract.

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Abstract

The invention discloses a Chinese medicine composition for treating hypertensive nephropathy and a preparation method and application of the Chinese medicine composition. The Chinese medicine composition is prepared from the raw materials in parts by mass: 10-20 parts of rhizoma gastrodiae, 10-20 parts of uncaria rhynchophylla, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of herba epimedii, 20-40 parts of astragalus membranaceus, 20-40 parts of red-rooted salvia root, 20-40 parts of serissa serissoides and 6-15 parts of pinellia ternata. The preparation method specifically comprises the following steps of: weighing all Chinese medicinal herbs except for the uncaria rhynchophylla according to a proportion; adding water for decocting and extracting at a first time; then adding the uncaria rhynchophylla; adding water for decocting and extracting at a second time; and mixing two decoction extraction solutions, filtering, concentrating, centrifuging, and drying to prepare a dry extract. Clinical experiments indicate that the Chinese medicine composition has the functions of remarkably improving clinical symptoms of a patient suffering from hypertensive nephropathy, reducing blood pressure, blood beta2-M and 24h urine protein content, and improving hypohemia and kidney function, and can be expected to be used for preparing medicine preparations for treating the hypertensive nephropathy, and has an officinal prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating hypertensive nephropathy, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] According to statistics, among the primary diseases of hemodialysis patients in my country, hypertensive nephropathy ranks third. The incidence of renal complications in hypertensive patients is 42%, second only to cardiac complications, and about 10% of hypertensive patients die of chronic renal failure. In recent years, the incidence of hypertension has been increasing, and hypertensive nephropathy has become the second cause of chronic renal failure, which has seriously endangered the health and life of patients. The medical treatment of hypertensive nephropathy is quite difficult. At present, Western medicine mainly uses angiotensin converting enzyme inhibitors and calcium ion antagonists, etc., with...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P9/12A61P13/12
Inventor 施志琴张汉新黄美琴麻志恒
Owner 上海交通大学医学院附属新华医院崇明分院
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