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Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation

A compound preparation and ovarian cancer technology, applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of not having a prominent "attacking evil" effect, reduce toxic and side effects, and increase five-year survival rate , the effect of improving tolerance and compliance

Inactive Publication Date: 2012-09-19
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is not difficult to see that these traditional Chinese medicines all take strengthening the body as the main effect, play the role of adjuvant radiotherapy and chemotherapy, and do not highlight the role of "attacking evil"

Method used

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  • Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Take the formula amount of Astragalus medicinal material and add 4 times the amount of 40% ethanol for reflux extraction once, 0.5h / time, to obtain Astragalus alcohol extract; after the dregs are evaporated to dry ethanol, add the remaining ten medicinal materials (Dangshen, Shengdi, Scutellaria barbata, Atractylodes macrocephala, Radix Asparagus, Lycium barbarum, Antler Cream, August Zha, Muxiang, Paeoniae Alba) add 4 times the amount of water to reflux and extract once, 0.5h each time, the water extract is concentrated under reduced pressure to a density of 1.0, and ethanol is added to The concentration is 50% for alcohol precipitation, static filtration, the filtrate is combined with the astragalus alcohol extract, concentrated under reduced pressure to a density of 1.0, 2Kg dextrin is added, and spray-dried to obtain an extract powder; the obtained extract powder is added with 4Kg dextrin, mixed Uniform, dry granulation, granulation, after passing the inspection, put...

Embodiment 2

[0037] Add 12 times the amount of Astragalus membranaceus medicinal materials and reflux extraction with 80% ethanol for 4 times, 2.5h / time to obtain Astragalus membranaceus alcohol extract; after the dregs are evaporated to dry ethanol, add the remaining ten herbs (Dangshen, Shengdi, Scutellaria barbata, Atractylodes macrocephala , asparagus, medlar, antler cream, August Zha, muxiang, white peony), add 12 times the amount of water to reflux and extract 4 times, 2.5h each time, the water extract is concentrated under reduced pressure to a density of 1.4, and ethanol is added to the concentration Carry out alcohol precipitation to 90%, stand and filter, combine the filtrate with the astragalus ethanol extract, concentrate under reduced pressure to a density of 1.4, add 8Kg dextrin, and spray dry to obtain extract powder; add 16Kg dextrin to the obtained extract powder, mix well , dry granulation, granulation, after passing the inspection, put it into a composite aluminum-plastic...

Embodiment 3

[0040]Take the formula amount of Radix Astragali and add 6 times the amount of 60% ethanol to reflux extraction for 3 times, 1.5h / time to obtain Astragalus ethanol extract; after the dregs are evaporated to dry ethanol, add the remaining ten medicinal materials (Dangshen, Shengdi, Scutellaria barbata, Atractylodes macrocephala , asparagus, wolfberry, antler cream, August Zha, woody fragrance, white peony), add 8 times the amount of water to reflux and extract 3 times, 1h each time, the water extract is concentrated under reduced pressure to a density of 1.1, and ethanol is added to a concentration of 1.1 70% alcohol precipitation, static filtration, the filtrate and astragalus ethanol extract were combined, concentrated under reduced pressure to a density of 1.1, added 4Kg dextrin, and spray-dried to obtain an extract powder; the obtained extract powder was added with 8Kg dextrin, mixed evenly, Dry granulation, granulation, after passing the inspection, put it into a composite ...

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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for treating ovarian cancer and a preparation method of the traditional Chinese medicine compound preparation. According to the traditional Chinese medicine compound preparation, extracts of bulk medicine such as astragalus mongholicus, codonopsis pilosula, rehmannia root, sculellaria barbata, asparagus cochinchinensis, medlar, cornu cervi, fiveleaf akebia fruit, elecampane and radix paeoniae alba are prepared into solid and liquid preparations. Animal experiment results show that the weight loss and the white cell reduction can be relieved, the T lymphocyte function is improved, the bax expression is increased, the cancer cell apoptosis is promoted, the anti-tumor angiogenesis effect is realized, the oxygen deficiency microenvironment of tumor cells is improved, and the sensitivity of ovarian cancer cells on chemotherapeutics is enhanced. Clinical test results show that the clinical symptoms of later-stage ovarian cancer patients can be relieved, and the survival quality of patients is improved; the chemotherapy toxic and side effect is lightened, and the chemotherapy tolerance and the compliance of the patients are improved; and the uncontrolled and recurrence rate of later-stage ovarian cancer can be reduced, and the five-year survival rate is improved; and no obvious adverse reaction exists, and good safety is realized. The traditional Chinese medicine compound preparation is applicable to the treatment on ovarian cancer and ovarian cancer postoperative chemotherapy patients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating ovarian cancer and a preparation method thereof. Background technique [0002] Ovarian cancer (ovarian cancer, OC) has an insidious onset and rapid progression. Its incidence rate ranks third among gynecological malignancies, but its mortality rate ranks first. According to reports, due to the lack of specific early diagnosis methods, about 75% of patients are diagnosed at an advanced stage, and less than 40% of patients with epithelial ovarian cancer can be cured. In recent years, with the birth and clinical application of new chemotherapy regimens, The development of tumor cytoreductive surgery and the emergence of biological therapy have brought new hope to people, but the 5-year survival rate of patients with stage III and stage IV ovarian cancer is still hovering around 29% and 13%. At present, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61P35/00A61K35/32
Inventor 齐聪张勤华胡欣欣
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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