A kind of anti-scar silicone gel patch and preparation method thereof

A technology of silicone gel patch and silicone gel patch, which is applied in the field of medicine and can solve problems such as using without combination

Active Publication Date: 2021-04-27
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that previous studies have reported the anti-scar research of silicone gel patches, pentoxifylline and tamoxifen, but there is no precedent for combining the two in the prior art

Method used

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  • A kind of anti-scar silicone gel patch and preparation method thereof
  • A kind of anti-scar silicone gel patch and preparation method thereof
  • A kind of anti-scar silicone gel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An anti-scar silicone gel patch, comprising a silicone gel patch and a plastic film; the silicone gel patch includes a silicone gel layer and a textile layer; by weight percentage, the silicone gel layer contains 11% other Moxifen, 9% pentoxifylline and 80% organosilicon polymer; the thickness of the silicone gel layer is 1mm, and the weight of the silicone gel layer is 1g.

[0027] The silicone polymer is any mixture of dimethicone and vinyl dimethicone. Among them, polydimethylsiloxane was purchased from Shanghai Resin Factory Co., Ltd., with a number-average molecular weight of 6000-7000 and a viscosity of 7000cp at 25°C; vinyl polydimethylsiloxane was purchased from Wacker, Germany, with a number-average molecular weight of It is 60,000-80,000, the vinyl content is 4-6%, and the viscosity is 50,000cp at 25°C.

[0028] The preparation method of described anti-scar silicone gel patch, comprises the following steps:

[0029] (1) Tamoxifen, pentoxifylline and silicone...

Embodiment 2

[0033] An anti-scar silicone gel patch, comprising a silicone gel patch and a plastic film; the silicone gel patch includes a silicone gel layer and a textile layer; by weight percentage, the silicone gel layer contains 14% other Moxifen, 7% pentoxifylline and 79% organosilicon polymer; the thickness of the silicone gel layer is 2mm, and the weight of the silicone gel layer is 2g.

[0034] The type of the silicone polymer and the preparation method of the anti-scar silicone gel patch are the same as in Example 1.

Embodiment 3

[0036] An anti-scar silicone gel patch, comprising a silicone gel patch and a plastic film; the silicone gel patch includes a silicone gel layer and a textile layer; by weight percentage, the silicone gel layer contains 10% other Moxifen, 8% pentoxifylline and 82% organosilicon polymer; the thickness of the silicone gel layer is 1.5mm, and the weight of the silicone gel layer is 1.5g.

[0037] The type of the silicone polymer and the preparation method of the anti-scar silicone gel patch are the same as in Example 1.

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Abstract

The invention belongs to the field of medicine, and in particular relates to an anti-scar silicone gel patch and a preparation method thereof. The anti-scar silicone gel patch includes a silicone gel patch and a plastic film; the silicone gel patch includes a silicone gel layer and a textile layer; by weight percentage, the silicone gel layer contains 10-14% Tamoxifen, 6‑10% pentoxifylline, and 75‑85% silicone polymer. Applying tamoxifen and pentoxifylline to silicone gel to make anti-scar silicone gel patch has obvious effect on reducing scar tissue formation. Compared with the lack of any one component, the combined use of the three can play a synergistic effect, can significantly inhibit the proliferation of skin scar cells, and effectively remove scar marks.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an anti-scar silicone gel patch and a preparation method thereof. Background technique [0002] Hypertrophic scars are pathological changes caused by various skin traumas, burns, infections, operations, etc. The mechanism of scar formation has not been fully elucidated, and there is still a lack of simple and effective prevention and treatment methods in clinical practice. At present, the wound healing process cannot be controlled to avoid scar formation. [0003] In 1983, when using the elastic band to compress the scar, researchers added silicone gel between the elastic band and the scar to prevent direct friction. It was found that after such treatment, the effect was much better than that of the elastic band alone. Thus uncovered the inhibitory effect of silicone gel on scars and received extensive attention. Various silicone gel products have come out one after another,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/34A61K31/138A61K31/522A61P17/02
CPCA61K9/7023A61K31/138A61K31/522A61K47/34A61P17/02A61K2300/00
Inventor 李力群李子豪张宏宇张梓凯
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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