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Muscular amino acids and nucleosides injection medicinal composition and preparation method thereof

A technology of carnosine glycoside injection and peptide glycoside injection, which is applied in the field of biochemical pharmacy, can solve the problems of limited therapeutic effect of cardiovascular and cerebrovascular diseases, and achieve the goal of improving blood rheology, improving therapeutic effect, and promoting potassium ion influx Effect

Inactive Publication Date: 2012-10-03
长春白求恩制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug has a limited therapeutic effect on cardiovascular and cerebrovascular diseases. It was determined by the determination method for the determination of the activity of calf blood deproteinized extract injection in the national drug standard. Enhanced effect, but the stimulation index (SI) activity is only about 1.4

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Carnosine glycoside solution

[0066] Rabbit heart and muscle, after fat removal, mixed with water for injection at a weight ratio of 0.75:1, homogenized with a high-speed tissue grinder, cooled to 4°C for 2 hours, added 1g / L diatomaceous earth, Heat at 105°C for 8 minutes, press filter with a small plate and frame filter press, filter with a 0.45 μm microporous membrane, and ultrafilter with an 8000 molecular weight ultrafiltration membrane (reaching the molecular weight requirements of the quality standard for carnosine injection) to obtain carnosine Solution, measure the peptide content, add water for injection to adjust the solution peptide concentration to 1.65~2.00mg / ml, hypoxanthine concentration to 0.250~0.287 mg / ml.

[0067] 2. Add 1000ml of the carnosine glycoside solution obtained above, add 1g of pentoxifylline, add 15g of sodium fructose diphosphate, add 18g of polyethylene glycol 200, and sterilize under high pressure at 121°C for 20 minutes after packa...

Embodiment 2

[0069] 1. Carnosine glycoside solution

[0070] Rabbit heart and muscle, after fat removal, mixed with water for injection at a weight ratio of 0.79:1, homogenized with a high-speed tissue grinder, cooled to 4°C for 2 hours, added 1g / L diatomaceous earth, Heat at 105°C for 8 minutes, press filter with a small plate and frame filter press, filter with a 0.45 μm microporous membrane, and ultrafilter with an 8000 molecular weight ultrafiltration membrane (reaching the molecular weight requirements of the quality standard for carnosine injection) to obtain carnosine Solution, measure the peptide content, add water for injection to adjust the solution peptide concentration to 1.65~2.00mg / ml, hypoxanthine concentration to 0.250~0.287 mg / ml.

[0071] 2. Add 1000ml of the carnosine glycoside solution obtained above, add 0.2g of pentoxifylline, add 10g of sodium fructose diphosphate, add 10g of polyethylene glycol 200, and sterilize under high pressure at 121°C for 20 minutes after dis...

Embodiment 3

[0073] 1. Carnosine glycoside solution

[0074] Rabbit heart and muscle, after fat removal, mixed with water for injection at a weight ratio of 0.75:1, homogenized with a high-speed tissue grinder, cooled to 4°C for 2 hours, added 1g / L diatomaceous earth, Heat at 105°C for 8 minutes, press filter with a small plate and frame filter press, filter with a 0.45 μm microporous membrane, and ultrafilter with an 8000 molecular weight ultrafiltration membrane (reaching the molecular weight requirements of the quality standard for carnosine injection) to obtain carnosine Solution, measure the peptide content, add water for injection to adjust the solution peptide concentration to 1.65~2.00mg / ml, hypoxanthine concentration to 0.250~0.287 mg / ml.

[0075] 2. Add 1000ml of the carnosine glycoside solution obtained above, add 1g of pentoxifylline, add 20g of sodium fructose diphosphate, add 20g of polyethylene glycol 200, and sterilize under high pressure at 121°C for 20 minutes after packa...

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PUM

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Abstract

The invention provides a muscular amino acids and nucleosides injection medicinal composition and discloses a preparation method of the medicinal composition. The medicinal composition is prepared from a muscular amino acids and nucleosides injection, pentoxifylline, fructose diphosphate sodium and polyethylene glycol. When the medicinal composition is applied in vitro, the liver homogenate breathing activity of a guinea pig can be increased, an activity stimulation index of breathing activity determined by using a Warburgs respirometer is about 4.2, which is far higher than the stimulation index of the liver homogenate breathing activity of the guinea pig during separate testing by using muscular amino acids and nucleosides, the pentoxifyllinum and the fructose diphosphate sodium, and thus, the treating effect on heart cerebrovascular disease is enhanced greatly.

Description

technical field [0001] The invention provides a pharmaceutical composition for carnosine glycoside injection, and also discloses a preparation method of the pharmaceutical composition, which belongs to the technical field of biochemical pharmacy. Background technique [0002] The existing "sarcosaminopeptide glycoside injection" is a prescription drug in my country, which is extracted from the muscle and heart muscle of healthy rabbits and is a sterile aqueous solution containing polypeptides, amino acids, nucleosides and nucleotides. Carnosine glycoside injection has the effects of improving blood circulation disorders, reducing vascular resistance, and increasing myocardial oxygen utilization for cardiovascular system diseases. It can promote the activity of the hematopoietic system, increase the number of white blood cells, increase the elasticity of blood vessels, and prevent arteriosclerosis. Carnosine glycosides are used for brain dysfunction; cerebral apoplexy, cerebr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/24A61K9/08A61K47/34A61P9/00A61K31/522A61K31/7024A61K31/765
Inventor 王巍
Owner 长春白求恩制药有限公司
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