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Chinese medicinal preparation for treating infantile epilepsia and preparation method thereof

A technology for traditional Chinese medicine preparations and epilepsy, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as strong drug dependence, toxic side effects, and inability to achieve treatment, and achieve long-term curative effects. Less toxic and side effects, less relapse effect

Inactive Publication Date: 2011-09-14
安玉胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(5) Adverse factors are easy to induce: children are prone to seizures under the influence of adverse factors (such as fever, irregular life, overeating, etc.)
Western medicine and western medicine have their advantages in controlling epileptic seizures, but too strong inhibitory effect will affect the brain nerve function and produce obvious toxic side effects
For example, carbamazepine, yingal, epileptamine, etc., not only cannot completely cure epilepsy, but also fail to achieve the purpose of treatment, but also have large side effects, strong drug dependence, and produce unavoidable side effects such as mental depression, IQ, and mental retardation. Therefore, it is not easy to be accepted by patients
In addition, often taking anti-epileptic western medicines can easily lead to drug adaptation. If you want to maintain a certain curative effect, you have to increase the dose, forming a vicious circle

Method used

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  • Chinese medicinal preparation for treating infantile epilepsia and preparation method thereof
  • Chinese medicinal preparation for treating infantile epilepsia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The preparation method of the tablet of the present invention comprises: first extracting 500g of Dannanxing, 500g of Pinellia, 500g of Earthworm and 500g of Scorpion with ethanol, the amount of ethanol is the 10 times the sum of parts by weight of scorpion, heated and refluxed for 30 to 45 minutes each time, filtered the 2 extracts and put them together; the filtrate was left to stand for later use; then add ethanol to 1500g of Evodia rutaecarpa, 1500g of Shichangpu and 1500g of Gastrodia elata , heating and extracting 2 times, the amount of ethanol is 10 times the sum of the weight parts of Evodia rutaecarpa, Shichangpu and Gastrodia elata, heating and refluxing for 20 minutes to 30 minutes each time, combining the 2 extracts, recovering ethanol under reduced pressure, The obtained medicinal liquid is left to stand, and the obtained medicinal liquid is filtered and left to stand for subsequent use; then 1500g of the remaining components of the silkworm, Uncaria 1500g, ...

experiment example 3

[0065] Experimental example 3: Cumulative toxicity test:

[0066] Chinese medicine preparation capsule of the present invention is to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine preparation of the present invention is to mice The hair, behavior, defecation, body weight, organ weight, hemogram, liver and kidney function, blood sugar, blood lipid and other indicators of the rats had no significant impact, and no abnormal changes were found in the organs with the naked eye. After taking the medicine for 3 weeks, there was no obvious change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

[0067] Skin and in vivo...

specific Embodiment 1

[0131] Specific examples 1. Fu, male, 14 months, came to our hospital for medical treatment in June, 2005. There was no obvious inducement for sudden onset half a year before the medical treatment, with both hands clenched tightly, bruised lips, pale complexion, looking up with both eyes, and vomiting Saliva, unconscious 1-2 minutes later wake up, as usual. Gradually increase from once a month outbreak to several times a month frequent outbreak, nearly 2 months outbreak 4-5 times every week, take the traditional Chinese medicine of the present invention, prescription: Dannanxing 2g, white silkworm 10g, pinellia 3g, Uncaria 10g, Dilong 4g, Bupleurum 10g, Shichangpu 10g, Gastrodia elata 10g, Cicada slough 10g, Evodia 4g, Gardenia kernel 10g, Corydalis 10g, Polygala 10g, Gypsum 10g, Ophiopogon 15g, Albizia bark 10g, Angelica 10g , Codonopsis 15g, Chuanxiong 10g, Scorpion 2g. Make it into a umbilicus patch, and stick one pair on the navel every day. After half a month, there is ...

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Abstract

The invention relates to a Chinese medicinal preparation for treating infantile epilepsia, which comprises the following raw material medicaments in part by weight: 1 to 10 parts of arisaema cum bile, 10 to 20 parts of stiff silkworm, 1 to 10 parts of pinellia tuber, 10 to 20 parts of gambir plant, 1 to 10 parts of earthworm, 10 to 20 parts of bupleurum, 10 to 20 parts of grassleaf sweelflag rhizome, 10 to 20 parts of tall gastrodia tuber, 10 to 20 parts of cicada slough, 1 to 10 parts of evodia fruit, 10 to 20 parts of fructus gardeniae seed, 10 to 20 parts of yanhusuo, 10 to 20 parts of polygalae, 10 to 20 parts of gypsum, 10 to 20 parts of dwarf lilyturf tuber, 10 to 20 parts of silktree albizzia bark, 10 to 20 parts of Chinese angelica, 10 to 20 parts of szechuan tangshen root, 10 to 20 parts of szechuan lovage rhizome and 1 to 10 parts of scorpion. The Chinese medicinal preparation controls the symptoms of the epilepsia and repairs and regenerates damaged cranial nerves fundamentally by combining the improvement of cerebral functions, namely brain invigoration and mentality promotion, conditioning by traditional Chinese medicines and epilepsia resistance, and has the effect of addressing root causes; and the side effect caused by western medicines is offset or resisted by the mutual effect of the medicaments, so that the Chinese medicinal preparation can be taken by infants safely. In addition, the Chinese medicinal preparation has good long-term curative effect, and the infantile epilepsia is difficult to relapse.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating epilepsy in children and a preparation method thereof. Background technique [0002] Pediatric epilepsy, commonly known as "sheep's wind", is a common neurological syndrome with complex etiology and recurrent seizures in childhood. Caused by paroxysmal temporary brain dysfunction. Divided into two types, primary and secondary, the clinical manifestations are recurrent muscle twitching and disturbance of consciousness. Mainly due to the underdevelopment of the nervous system in children, the cerebral cortex is overexcited by high fever or severe mental stimulation. Those induced by hyperthermia are the most common. During convulsions, the vast majority of children are unconscious, with eyes closed or half-opened, eyeballs rolled up, jaws closed tightly, corners of the m...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/70A61K9/20A61P25/08A61K33/06A61K35/64A61K35/62A61K35/646
Inventor 安玉胜张洪英
Owner 安玉胜
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