Prepn process of brain protein hydrolysate injection

Abstract

The brain protein hydrolysate injection is prepared with health swine brain and contains 16 kinds of free amino acids and small amount of peptides. It is used in treating sequelae of craniocerebral trauma and cerebrovascular disease, improving cerebral function, etc. It is prepared through washing, homogenizing, thermal changing, enzyme hydrolysis, freezing, ultrafiltering, sterilizing and other steps.

Description

Technical field: [0001] The invention belongs to the technical field of medicine Background technique [0002] Brain protein hydrolyzate injection is a sterilized aqueous solution prepared by enzymatic hydrolysis of healthy pig brains. Each 1ml contains 28.08-42.14mg of free amino acids and 5.49-6.71mg of total nitrogen (N). It is used for craniocerebral trauma , Sequelae of cerebrovascular disease accompanied by improvement of symptoms of memory loss and attention deficit disorder. It can help to improve brain dysfunction, and it is also used for protein deficiency and neurasthenia patients for cases of general protein digestion and absorption disorders. [0003] This variety was first imported from Austria, and later produced in China. There are many literature reports on its technological process, and its process is roughly the process of degreasing, hydrolysis, ultrafiltration, chromatography, and deployment of amino acids. But in practice, we cannot produce qualified...

AI Technical Summary

Problems solved by technology

But in practice, we cannot produce qualified products according to the reported process, mainly because the other substances in the standard [inspection] items are more than 15%, and the color, especially in the storage process, cannot meet the requirements of light yellow clear liquid

In addition, the degreasing step requires an explosion-proof workshop. On the one hand, it increases the cost, and on the other hand, it is really unnecessary in the process.

The chromatography process is not realistic in practice