The invention discloses a multi-mode imaging
system for observing
cerebral cortex functions of moving animals, comprising a
light source device, an image transferring
optical fiber, a light transferring
optical fiber, a spectroscope, an intrinsic
signal imaging part, a
laser speckle contrast imaging part, a
fluorescence Imaging part, an
animal activity room, an
image acquisition card, a computer, wherein the
light source device generates three light sources needed by an imaging mode, the image transferring
optical fiber is used for transferring the
cerebral cortex images to a spectroscope when the animals moves around freely; the light transferring optical
fiber transfers the light of the
light source to the
cerebral cortex of the aminals; the spectroscope divides imaging
light beam transferred by the image transferring optical
fiber into three beams and carries out intrinsic
signal imaging,
laser speckle contrast imaging and
fluorescence Imaging; the intrinsic
signal imaging part is used for the intrinsic signal imaging; the
laser speckle contrast imaging part for laser speckle
contrast imaging; the
fluorescence Imaging part is used for fluorescence Imaging; the
animal activity room is used for the experiment animals to move freely; the
image acquisition card is used for
image acquisition and the computer for
system control and image receiving and
processing.In the invention, optical
fiber light and image transferring can be used to multi-mode imaging when the animals are conscious and active and the invention comprises intrinsic signal imaging, laser speckle
contrast imaging and fluorescence Imaging.