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Preparation method for traditional Chinese medicine composition for improving immunity of livestock and poultry and use thereof

A technology of composition and immunity, applied in the field of preparation of traditional Chinese medicine composition, can solve the problems of waste of resources, clogging of macroporous resin columns, pollution, etc., and achieve the effect of reducing losses

Active Publication Date: 2010-05-12
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the prescriptions containing Acanthopanax and Radix Astragali are mainly aimed at the polysaccharide components in them, and the method of boiling and alcohol precipitation is used to obtain the polysaccharide components in them, which are used in immune enhancement, anti-virus, anti-tumor, etc.; and among them During the extraction process, the total glucosides of Acanthopanax senticosus will lose most of it due to the process, and even there will be a phenomenon that it is not extracted at all; so the effective components in it cannot be fully utilized, resulting in a waste of resources
Chinese patent CN1424057A discloses that the combination of Acanthopanax and Radix Astragali is subjected to water extraction and alcohol precipitation, and only Acanthopanax and Astragalus crude polysaccharides are obtained, while the total glycosides of Acanthopanax senticosus with anti-stress effects have not been utilized
Chinese patent CN1285344C discloses that the total glycosides and polysaccharides of Acanthopanax senticosus are extracted by double extraction method with alcohol and water, and the total glycosides are purified and refined by macroporous adsorption resin column, and the extract is dissolved in water and centrifuged. The supernatant was purified through a macroporous resin column. Although the problem of particle contamination and blockage of the macroporous resin column in the upper extract was solved, it was easy to cause the loss of some glycosides with less water solubility.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] ① Take 5 kg of Acanthopanax, crush it through 10 meshes, add 10 times the amount of 60% ethanol to dynamically impregnate for 1 hour, reflux extraction for 3 hours, leave the extract overnight, recover the ethanol from the supernatant under reduced pressure until it has no alcohol smell, add 10% ethanol Make 1g of crude drug / ml, centrifuge, add the supernatant to the macroporous adsorption resin column, first elute with water until the Molisch reaction is negative, then use 20% ethanol with 2 times the volume of the column, and 80% with 4 times the volume of the column Eluted with ethanol, collected 20% and 80% ethanol eluted parts, combined to obtain eleutherosides;

[0027] ② Take 3kg of Astragalus membranaceus, slice it, and mix it with ethanol extraction and Acanthopanax acanthopanax dregs, add 10 times the amount of water for dynamic immersion for 2 hours, vacuum and dynamic extraction for 4 hours at 70°C, collect the extract, and pass the extract and Acanthopanax a...

Embodiment 2

[0030] ① Take 7kg of Acanthopanax, crush it through 20 meshes, add 10 times the amount of 70% ethanol to dynamically impregnate for 1 hour, reflux extraction for 3 hours, leave the extract overnight, recover the ethanol from the supernatant under reduced pressure until it has no alcohol smell, add 5% ethanol Make 1g crude drug / ml, centrifuge, add the supernatant to the macroporous adsorption resin column, first elute with water until the Molisch reaction is negative, then use 30% ethanol 4 times the volume of the column, 80% ethanol 8 times the volume of the column Eluted with ethanol, collected 30% and 80% ethanol eluted parts, combined to obtain eleutherosides;

[0031] ② Take 4kg of Astragalus membranaceus, slice it, and mix it with ethanol-extracted Acanthopanax senticosus dregs, add 10 times the amount of water for dynamic impregnation for 2 hours, vacuum dynamic extraction for 4 hours at ≤70°C, collect the extract, and oversize the extract with Acanthopanax acanthopanax ...

Embodiment 3

[0034]① Take Acanthopanax 6kg, crush it through 20 meshes, add 12 times the amount of 80% ethanol to dynamically impregnate for 1 hour, reflux extraction for 3 hours, leave the extract overnight, recover the ethanol from the supernatant under reduced pressure until it has no alcohol smell, add 10% ethanol Make 1g of crude drug / ml, centrifuge, add the supernatant to the macroporous adsorption resin column, first elute with water until the Molisch reaction is negative, then use 30% ethanol with 2 times the volume of the column, and 70% of the column volume with 6 times the volume Ethanol elution, collecting 30% and 70% ethanol elution parts, combined to obtain eleutherosides;

[0035] ②Take 2kg of Astragalus membranaceus, slice it, mix it with the dregs of Acanthopanax senticosus after ethanol extraction, add 12 times the amount of water for dynamic immersion for 2 hours, vacuum dynamic extraction for 4 hours at ≤70°C, collect the extract, and oversize the extract with Acanthopan...

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PUM

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Abstract

A preparation method for a traditional Chinese medicine composition for improving immunity of livestock and poultry relates to a traditional Chinese medicine composition. The preparation method comprises the following steps: taking acanthopanax root, crushing and sifting; adding ethanol to dynamically soaking and performing reflux extraction; depressurizing the supernatant and recycling ethanol from the supernatant until no alcohol smell is detected; adding ethanol of low concentration to be prepared into crude drug; centrifuging and putting supernatant on macro-porous absorption resin column; using water to elute reaction negativity and successively eluting by ethanol, then collecting ethanol and eluted part of ethanol and combining to obtain acanthopanax total glucoside; taking astragalus root and extracting with ethanol, then mixing with acanthopanax root dregs; filtering and recycling ethanol from filter liquid to obtain total polysaccharide; combining acanthopanax total glucoside with total polysaccharide and filling into bottles, then sterilizing to obtain injection liquid. The invention uses the technical solution in combination with ethanol extraction method and water extraction method to extract acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide. The acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide are added with excipient and processed by common procedures or added with pharmaceutically acceptable excipient to be made into clinically acceptable dosage forms.

Description

【Technical field】 [0001] The invention relates to a traditional Chinese medicine composition, in particular to a preparation method and application of a traditional Chinese medicine composition which can effectively improve the immunity of livestock and poultry. 【Background technique】 [0002] At present, with the scale and industrialization of livestock and poultry production, the degree of intensification of breeding is getting higher and higher, and the incidence of stress syndrome is constantly increasing. In the process of livestock and poultry production, stress response and decreased immunity will inevitably occur in group transfer, transportation, capture, vaccination and other work. [0003] For example, the high temperature season in summer is the most difficult period for chicken production. When the temperature is higher than 33°C, the normal production of laying hens will be seriously affected, the egg production rate will decrease, and the mortality rate and eg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P37/04
Inventor 刘兴金李兴国
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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