The present invention relates to composition combined with natural plant and its preparation method, especially relates to preventing altitude sickness composition and its preparation method. A preventing highland reaction food composition produced by following weight and percentage of the raw materials: red common stonecrop herb 8 to 20 percent, safflower 8 to 20 percent, ginkgo biloba leaves 1 to 80 percent, lanceolata 1 to 70 percent. The method for manufacturing bagged tea of the said preventing altitude sickness food composition is that drying red common stonecrop herb 8 to 20 percent, safflower 8 to 20 percent, lanceolata 1 to 70 percent, and ginkgo biloba leaves 1 to 80 percent under 30 to DEG C and mixing grinding; sieving 40 to 60 mesh sieve, packaging bagged tea, external packing adopts vacuum package. The present invention advantages is that providing a tea, oral liquid, capsule and granule composition and its preparation method, with anti- hypoxia, anti-fatigue, anti-radiation, blood-activation and stasis-eliminating, promoting blood cycle in brain, enhancing immunity effects, and the effects are striking, suitable for each kind symptoms of altitude sickness, without side effects and non-toxic.