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Application of sika deer spleen extract to antioxidant medicines

An anti-oxidation, sika deer technology, applied in the direction of application, drug combination, medical preparations containing active ingredients, etc., to achieve the effect of enhancing SOD activity and increasing content

Active Publication Date: 2015-01-28
北京中京丰创科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of development and research on deer spleen, there is currently no report on the antioxidant properties of deer spleen extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] . Weigh 250g of sika deer spleen, remove the surface connective tissue, and cut into 0.5cm thick slices;

[0025] . Add 800ml of normal saline and grind for 5 minutes with a colloid mill;

[0026] .Heat the deer spleen suspension to 40°C, adjust the pH value to 5.0, add 2.0g of papain and keep it in a water bath for 1.5h;

[0027] . Continue to add 1.5g 5'-phosphodiesterase to incubate for 2~3h;

[0028] . Centrifuge the suspension at 4000g for 10 minutes to take the supernatant, perform ultrafiltration with a 10KD ultrafiltration membrane to obtain the ultrafiltrate, and spray dry to obtain the deer spleen extract dry powder with antioxidant effect. The content of peptides in deer spleen extract dry powder is 30%, the content of nucleotides is 1.2%, and the content of vitamins is 0.05%.

Embodiment 2

[0030] . Weigh 250g of sika deer spleen, remove the surface connective tissue, and cut into 0.5cm thick slices;

[0031] . Add 860ml of normal saline and grind for 5 minutes with a colloid mill;

[0032] .Heat the deer spleen suspension to 45°C, adjust the pH value to 5.5, add 2.2g of papain and keep it in a water bath for 1h;

[0033] . Continue to add 1.5g 5'-phosphodiesterase to incubate for 3h;

[0034] . Centrifuge the suspension at 4000g for 10 minutes to take the supernatant, perform ultrafiltration with a 10KD ultrafiltration membrane to obtain the ultrafiltrate, and spray dry to obtain the deer spleen extract dry powder with antioxidant effect. The content of peptides in deer spleen extract dry powder is 35%, the content of nucleotides is 1.5%, and the content of vitamins is 0.1%.

Embodiment 3

[0036] . Weigh 250g of sika deer spleen, remove the surface connective tissue, and cut into 0.5cm thick slices;

[0037] . Add 1300ml of normal saline, grind for 2.5min with a colloid mill;

[0038] .Heat the deer spleen suspension to 50°C, adjust the pH value to 5.5, add 4.5g of papain and keep it in a water bath for 1.5h;

[0039] . Continue to add 2.5g 5'-phosphodiesterase to incubate for 2h;

[0040] . Centrifuge the suspension at 4000g for 10 minutes to take the supernatant, perform ultrafiltration with a 10KD ultrafiltration membrane to obtain the ultrafiltrate, and spray dry to obtain the deer spleen extract dry powder with antioxidant effect. The content of peptides in deer spleen extract dry powder is 40%, the content of nucleotides is 2.0%, and the content of vitamins is 0.15%.

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PUM

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Abstract

The invention relates to application of a sika deer spleen extract to antioxidant medicines. Animal experiments show that the sika deer spleen extract prepared by the process provided by the invention can reduce peroxides and protein carbonyls in serum of an ethanol-damaged mouse model, increase the content of reductive glutathione and enhance the activity of SOD in the serum, has an antioxidant effect, and can be used for preparing the antioxidant medicines and health-care food.

Description

Technical field: [0001] The invention relates to the application of sika deer spleen extract in antioxidant drugs, uses the sika deer spleen extract to prepare medicines or health care products, and belongs to the technical field of biopharmaceuticals. technical background: [0002] Oxidation is the biggest threat to skin aging. Unhealthy diet, sun exposure, stress, environmental pollution, etc. can cause free radicals to flood the skin, resulting in dull complexion, dehydration and other oxidation phenomena. Studies have proved that the antioxidant system of the human body is a system with complete and complex functions comparable to the immune system. The stronger the body's antioxidant capacity, the healthier it is and the longer its life. [0003] All parts of the sika deer have the effect of medicinal diet therapy. Dating back to ancient times, ancient books such as "Shen Nong's Materia Medica", "Compendium of Materia Medica", and "Ben Jing Feng Yuan" included deer pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/26A61P39/06A23L1/29A23L33/00
CPCA23V2002/00A61K35/26A23V2200/302A23V2250/204
Inventor 滕利荣彭小君卢文倩王艳菲孟威刘艳蔡广胜滕乐生逯家辉王贞佐程瑛琨王迪
Owner 北京中京丰创科技有限公司
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