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Application of artemether to prevention and treatment of Alzheimer disease

Artemether and drug technology, applied in the application field of traditional Chinese medicine monomers, to reduce amyloid plaque deposition, improve function, inhibit glial cell activity, and improve oxidative damage

Inactive Publication Date: 2019-03-01
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no literature disclosing the use of artemether in the treatment of Alzheimer's disease

Method used

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  • Application of artemether to prevention and treatment of Alzheimer disease
  • Application of artemether to prevention and treatment of Alzheimer disease
  • Application of artemether to prevention and treatment of Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Effect of different concentrations of artemether on improving learning and memory ability of Alzheimer's disease model mice

[0040] First, when the Alzheimer's disease transgenic mouse model (3xTg AD) was bred to 12 months of age, the mice were injected intraperitoneally with different concentrations of artemether every day. After 4 weeks of administration, the Morris water maze was performed. experiment, and then take materials for follow-up experiments.

[0041] Forty Alzheimer's disease transgenic mice were divided into 4 groups, 10 in each group. The body weight was weighed before administration, and the dosage was calculated according to the body weight. The drug was administered once a day, and the Morris water maze test was performed one month after the administration. The Morris water maze consists of a movable platform. There are four equidistant marking points on the wall of the pool, which serve as the water entry points for the mice. The pool is...

Embodiment 2

[0044] Example 2: Effects of Artemether at Different Concentrations on Neuronal Morphology and Apoptosis in the Brain of Alzheimer's Disease Transgenic Mouse Model (3xTg AD)

[0045] Forty Alzheimer's disease transgenic mice were divided into 4 groups, 10 in each group. The body weight was weighed before administration, and the dosage was calculated according to the body weight. The mice were administered daily, and after one month of administration, the mice were sacrificed by decapitation, and the brain tissues were fixed, embedded, and sectioned for later use.

[0046] The mice in each group were perfused with normal saline to clear the blood and then sacrificed. The whole brains of the mice were quickly taken out on ice, fixed in paraformaldehyde for 24 hours, and routinely dehydrated and embedded in transparent paraffin (70% ethanol for 2 hours, 80% ethanol for 2 hours, 90% ethanol for 1 h, 95% ethanol for 1 h, 100% ethanol I for 30 min, 100% ethanol II for 30 min, xylen...

Embodiment 3

[0052] Example 3: Effects of different concentrations of artemether on neurons in the brain of a transgenic mouse model of Alzheimer's disease (3xTg AD)

[0053] Forty Alzheimer's disease transgenic mice were divided into 4 groups, 10 in each group. The body weight was weighed before administration, and the dosage was calculated according to the body weight. The mice were administered daily, and after one month of administration, the mice were sacrificed by decapitation, and the brain tissues were fixed, embedded, and sectioned for later use.

[0054] The specific implementation method is as follows:

[0055] The mice in each group were perfused with normal saline to remove the blood and then sacrificed. The whole brain of the mice was quickly taken out on ice, fixed in paraformaldehyde for 24 hours, dehydrated with sucrose gradient, embedded in OCT, and sliced ​​in the coronal plane with a frozen microtome. , with a thickness of 10 μm. The cut frozen sections were fixed in a...

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Abstract

The invention discloses application of artemether to prevention and treatment of Alzheimer disease. The artemether is a safe and effective compound in anti-malaria treatment and activates an AMPK signal channel in the brain of an Alzheimer disease transgenic model mouse, the learning and memory ability of the Alzheimer disease transgenic model mouse is improved, apoptosis of nerve cells in the brain is reduced, the function of a choline acetyl transferase is improved, the activity of spongiocyte is inhibited, deposition of amyloid plaques, tangling of nerve fiber and the loss of nerve cells are reduced, and the experimental basis is provided for the clinical study for treating Alzheimer disease.

Description

technical field [0001] The invention relates to the application field of traditional Chinese medicine monomers, in particular to the application of artemether in the prevention and treatment of Alzheimer's disease. Background technique [0002] As the population ages, the impact of Alzheimer's disease is rapidly expanding globally. Alzheimer's disease (AD) is the most common form of neurodegenerative disease, characterized by generalized dementia such as memory impairment, aphasia, apraxia, agnosia, executive dysfunction, and behavioral changes. There are currently more than 40 million patients worldwide, and this number is expected to increase to 70 million by 2030, which will impose a serious social and economic burden on us. Its cause is still unknown, and there are currently no safe and effective drugs for the treatment of Alzheimer's disease. [0003] The Morris water maze is widely used in the research of learning and memory, senile dementia, and hippocampus. It has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P25/28
CPCA61P25/28A61K31/357Y02A50/30
Inventor 郑文华
Owner UNIVERSITY OF MACAU
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