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Medicament for treating senile dementia

A technology for senile dementia and drugs, applied in the field of medicine

Inactive Publication Date: 2012-02-15
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the experiments in this article can only show that the volatile oil of Acorus calamus and β-asarone can improve memory. Whether it really has the effect of anti-senile dementia, or the effect of the combination of active ingredients, needs further development and research

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] The preparation of embodiment 1 dropping pill

[0173] Take 8g of β-asarone (prepared according to the freeze crystallization method of Chinese patent 1318367C) and 2g of eugenol (purchased from Sigma Company in the United States), and melt 10g of polyethylene glycol-4000 and 60g of polyethylene glycol-6000 at 80°C Add the mixture into the medicine, mix well, and after the air bubbles have dissipated, absorb the medicine liquid and drop it into liquid paraffin and other coolants at a suitable drop rate, let it stand for molding, take it out, and dry it to make a drop pill with a weight of about 0.03g . Take 10-15 capsules orally at a time, 3 times a day.

[0174]

Embodiment 2

[0175] The preparation of embodiment 2 coating dropping pills

[0176] Take 8g of β-asarone and 2g of eugenol, add the mixture of 10g of polyethylene glycol-4000 and 60g of polyethylene glycol-6000 melted at 80°C to the medicine, mix well, after the air bubbles are gone, draw the medicine solution for appropriate The dropping speed is dropped into liquid paraffin and other coolants, and taken out after standing for molding. After drying, put the ball cores that meet the quality requirements in the coating pot to preheat for 10 minutes. The pressure of the coating pot is controlled at 0.4 MPa. The rotating speed of the coating pan was 55 rpm, and the flow rate of the coating solution was 20 ml / min. The coating solution (commercially available Slus film coating powder, purchased from Tianjin Slusen Pharmaceutical Material Technology Co., Ltd.) was first dissolved in 75% ethanol, and prepared into a solution with a concentration of 10%), spray it on the surface of the rotating ...

Embodiment 3

[0177] The preparation of embodiment 3 coating dropping pills

[0178] Take 8g of β-asarone and 2g of eugenol, add the mixture of 10g of polyethylene glycol-4000 and 60g of polyethylene glycol-6000 melted at 80°C to the medicine, mix well, after the air bubbles are gone, draw the medicine solution for appropriate The dropping speed is dropped into liquid paraffin and other coolants, and taken out after standing for molding. After drying, put the ball cores that meet the quality requirements in the coating pot to preheat for 10 minutes. The pressure of the coating pot is controlled at 0.4 MPa. The rotating speed of the coating pan was 55 rpm, and the flow rate of the coating solution was 20 ml / min. The coating solution (commercially available Slus film coating powder, purchased from Tianjin Slusen Pharmaceutical Material Technology Co., Ltd.) was first dissolved in 75% ethanol, and prepared into a solution with a concentration of 10%), spray it on the surface of the rotating ...

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Abstract

The invention provides a medicament for treating senile dementia, relating to the field of medicine, in particular to a pharmaceutical composition for treating senile dementia. The medicament for treating senile dementia contains compounds beta-asarone and eugenol in mass ratio of 4:1, and a pharmaceutically acceptable carrier can be added to prepared dripping pills, injections, oral solutions, soft capsules, hard capsules or tablets. A dripping pill provided by the invention is prepared from the compounds beta-asarol and eugenol by adding a polyethylene glycol substrate, and the weight ratio of the sum of the compounds beta-asarol and eugenol to the substrate is 1:7. A gastric-soluble coating can be added to the dripping pill to prepare a gastric-soluble film coated dripping pill, and the weight of the film coating is 2-4% of the total weight of the dripping pill.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine combination for treating senile dementia, which is mainly a medicine preparation composed of two compounds of beta-asarone and eugenol. Background technique [0002] Alzheimer's disease (English name Alzheimer's disease, referred to as AD) is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. Its clinical characteristics are insidious onset and progressive aggravation. The main manifestations are first short-term memory loss, and then progressive memory loss accompanied by different degrees of cognitive, language and personality abnormalities. With the intensification of population aging, AD is expected to be the top cause of death in this century. AD has brought enormous pressure to patients, their families and the society. The prevention and treatment of AD is not only a major medical problem,...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61K31/085A61P25/28A61K47/34A61K9/20A61K9/30A61K9/08A61K9/66A61K9/48
Inventor 魏刚陈云波陈东风江湧刘东辉刘柳芳程淑意周健洪王奇邓汝东张赛霞
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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