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Aromatic acid compound and application

A compound and acid technology, applied in the field of medicine, can solve the problem of no methyl mandelate

Inactive Publication Date: 2012-07-18
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, according to the literature survey on the chemical constituents of peach kernels, there is no report about methyl mandelate

Method used

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  • Aromatic acid compound and application
  • Aromatic acid compound and application
  • Aromatic acid compound and application

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental example 1 Structural identification experiment of methyl mandelate

[0027] The structure of the mandelate methyl ester prepared in Examples 1-3 can be identified using this experimental example.

[0028] White powder (methanol), ESI-MS m / z : 513.05[M+Na] + , 529.05[M+K] + , according to which the molecular weight is determined to be 490.05, combined with 1 H-NMR and 13 C-NMR data, deduce that this compound molecular formula is C 21 h 30 o 13 . 1 H-NMR (300 MHz, CD 3 OD) spectrum, δ : 7.38(2H, m), 7.54 (3H, m) are characteristic hydrogen signals of monosubstituted benzene, δ :5.48(1H, s) is the benzyl hydrogen signal, δ : 4.28(1H, d, J = 7.6Hz), 4.45(1H, d, J = 7.6Hz) are the signals of 2 sugar anogroup protons, δ : 3.71(3H, s) is the methoxyl proton signal; 13 C-NMR (75Mz, CD 3 OD) spectrum, δ : 173.3 is the carboxyl carbon signal, and 104.8 and 101.4 are the sugar terminal carbon signals. Comparing the carbon and hydrogen dat...

experiment example 2

[0031] Experimental example 2 Scopolamine-induced memory loss in mice

[0032] (1) Experimental materials

[0033] 1. Experimental animals

[0034] ICR mice, male, weighing 18-22 g, were provided by the Experimental Animal Center of Shenyang Pharmaceutical University, license number: SCXK (Beijing) 2009-0004.

[0035]2. Drugs and reagents

[0036] Test drug: methyl mandelate, dissolved with 0.5% CMC-Na before administration, and made into a solution.

[0037] Scopolamine Hydrobromide Injection: Shanghai Hefeng Pharmaceutical Co., Ltd., production batch number: 080701, the dose for mice is 3 mg / kg; Naofukang, Hubei Huazhong Pharmaceutical Co., Ltd., batch number: 20091224.

[0038] Equipment: platform jumper, self-made.

[0039] (2) Experimental method

[0040] 1. Grouping and administration

[0041] The ICR mice were randomly divided into 5 groups according to body weight, namely blank control group, model group, positive control group, high-dose and low-dose groups...

Embodiment 1

[0052] Embodiment 1: Get 1kg of peach kernel medicinal material, pulverize, adopt 70% ethanol aqueous solution to reflux extract at 80 ℃ for 4h, extract is concentrated under reduced pressure to obtain concentrate; Butanol extraction, ethanol, 70% ethanol and 95% ethanol gradient elution; 30% ethanol eluate, concentrated under reduced pressure, dried, and silica gel column chromatography, using volume ratios of 9:1, 8:2, 7 :3, 6:4, 5:5 dichloromethane-methanol mixed solvent elution, and then separated and purified by preparative HPLC, with acetonitrile-water with a volume ratio of 95:5 as mobile phase elution to obtain mandelate A Esters 20mg.

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Abstract

The invention belongs to the field of medicine, and relates to an aromatic acid compound separated from dry mature seeds of Prunuspersica (L.) Batsch or Prunusdavidiana (Carr.) Franch. and application of the aromatic acid compound in medicaments for preventing and treating senile dementia. The compound has the following structure, and is prepared by the steps of extraction, concentration, extraction, concentration and purification; and the compound has an obvious protective effect on damage of Abeta (25-35)-induced neuroblastoma cell strains SH-SY5Y, and has an effect of preventing and treating the senile dementia.

Description

technical field [0001] The invention relates to an aromatic acid monomer compound and its application, belonging to the technical field of medicine. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) was first discovered by the neuropathologist Alzheimer in 1906 and named after him. AD is a diffuse central neurodegenerative disease, a common senile neurodegenerative disease characterized by progressive cognitive impairment, mental decline, and personality changes, accounting for about 50% to 60% of all dementias. According to reports, about 3% of the elderly aged 65-74 suffer from AD, and the prevalence rate of the population aged 75-84 is 19%, while the prevalence of AD among the elderly aged > 85 is higher than 47%. The fourth leading cause of death in the elderly. Although there is a lack of authoritative and representative statistics for developing countries, it is estimated that 60% of the world's dementia patients exist in developing coun...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H1/08A61K31/7028A61P25/28
Inventor 毕开顺贾英李清黄健范旭航沈旭
Owner SHENYANG PHARMA UNIVERSITY
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