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Tetrapeptides for brightening the skin

A skin and skin color technology, applied in skin care preparations, cosmetic preparations, cosmetics, etc., can solve frequent skin irritation and other problems, and achieve the effect of relieving inflammation

Inactive Publication Date: 2012-07-11
TH GOLDSCHMIDT AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is frequent skin irritation

Method used

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  • Tetrapeptides for brightening the skin
  • Tetrapeptides for brightening the skin
  • Tetrapeptides for brightening the skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1: Brightening in vivo (2 month study)

[0080] In each case, 20 subjects applied test formulations without peptide or with 0.005% PKEK on one forearm for 8 weeks. Medial and lateral forearm melanin concentrations were measured using a Mexameter probe (Courage & Khazaka, Cologne) before the start of the study and after 8 weeks.

[0081] The measurement of melanin concentration in the skin is based on the principle of absorption / reflection. The Mexameter probe emits light of a specific wavelength that coincides with the absorption maximum of melanin in the skin. The light reflected by the skin is measured and set relative to the amount of light emitted. The resulting measurements are expressed as indices.

[0082] Formulations tested:

[0083]

[0084]

[0085] figure 1 The difference in melanin value after 8 weeks from the initial value is shown. Skin browning was significantly reduced on both the medial and lateral forearms compared to controls.

Embodiment 2

[0086] Example 2: Exemplary Formulations

[0087] Exemplary formulations are described below. The percentages are wt % and are the total weight of the exemplary formulation. Formulations are prepared using conventional formulation methods known to those skilled in the art.

[0088] O / W formulation

[0089] Phase A

[0090] W / O preparation

[0091] Phase A

[0092] Microcrystalline Wax

[0093] bath gel

[0094] water

[0095] O / W cream containing licorice extract

[0096] Phase A

[0097] PKEK

[0098] O / W cream containing licorice root extract

[0099]

[0100] O / W bath containing kojic acid

[0101] Phase A

[0102] W / O Bath with Arbutin

[0103] Phase A

[0104] O / W Body Butter with Hydroquinone

[0105] Phase A

[0106] O / W cream containing mulberry extract

[0107]

[0108]

[0109] O / W cream containing oxygenated resveratrol

[0110] Phase A

[0111] O / ...

Embodiment 3

[0126] Example 3: Reduction of facial age spots (altersflecken)

[0127] Age spots (Latin: Lentigines seniles, Lentigines solares) are pigmented diseases of the skin. They result from extensive, chronic exposure to ultraviolet radiation such as sunlight. This leads to the formation of hazel patches ("spots") with a locally distinct contour through an increase in melanin-producing melanocytes (primarily on the hands, forearms and the back of the skin of the face).

[0128] To quantify such age spots, a skin color measurement is performed. For this, a colorimeter is used. Color meter measures color value L * , a * and b * . exist figure 2 , describes the three-dimensional color space by which every perceptible color can be described.

[0129] in a * On the axis, green and red face each other as opposite colors, at b * On the axis, blue and yellow face each other as opposite colors. L * The axis gives the brightness. The endpoints are black (L=0) and white (L=100). ...

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Abstract

The invention relates to the use of the tetrapeptide PKEK for brightening human skin, for bleaching pigmented spots and / or for leveling out irregularities in skin coloration.

Description

technical field [0001] The present invention relates to the use of the tetrapeptide PKEK for lightening human skin, fading dark spots and / or eliminating uneven skin tone. Background technique [0002] The purpose of care cosmetics is to maintain the impression of an external youthful appearance, such as the impression of skin and hair. In principle, there are many ways to achieve this. For example, existing skin damage, such as irregular hyperpigmentation or wrinkling, can be remedied with a powder or cream. Another way is to protect the skin from environmental influences that lead to permanent damage and therefore skin aging. So the idea is to intervene in a preventative way, thereby delaying the aging process. [0003] The most important function of the skin is to protect the body from excessive water loss and, on the other hand, to prevent the entry of harmful chemicals or bacteria and solar radiation. Prolonged exposure of human skin to solar radiation can lead to li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/02
CPCA61K8/64A61Q17/04A61Q19/02
Inventor M·法尔维克U·莫查基维茨T·克勒
Owner TH GOLDSCHMIDT AG
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