38 results about "Skin marker" patented technology

The present invention provides methods for diagnosing melanoma in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample and compare them with a known skin age index. Therapeutic and cosmetic formulations are also provided herein.

The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.

The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a micro array.

A skin-marking device is disclosed that has a holder body and cap having a shape other than round, preferably triangular, to prevent the device from accidentally rolling off a flat surface. Measuring indicia is disposed on the device for accurately measuring distances. The device contains a dermatologically acceptable coloring agent for marking a patient's skin and one that may be selected from the group consisting of a radioopaque substance for x-ray diagnostic purposes, a fluorescent composition, a non-magnetic hydrogel for nuclear magnetic resonance imaging diagnostic purposes, a sterilizable gel ink, a combination of any of these, and a mixture of any of these. The holder body or cap may include a pocket clip or magnet attached thereto to permit the skin marker to be clipped inside a person's pocket or prevented from sliding off a magnetic drape or other magnetic surface, respectively. The skin marker may also come in a number of different sizes, one of which is optionally short enough to allow it to fit into a needle counter box to be packaged as part of a mini kit.

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

The present invention provides non-invasive methods for isolating an miRNA molecule from an epidermal sample, as well as detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to obtain the miRNA from epidermal samples, and may be used to further analyze expression of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.

A multi-density skin marker for medical imaging exams is provided. The skin marker contains a multi-density imaging body. In one embodiment, a multi-density skin marker includes a marker substrate and a multi-density imaging body supported by the marker substrate. The multi-density imaging body comprises a first portion having a first radiographic density and a second portion having a second radiographic density. The two radiographic densities differ, such that a radiographic image of the multi-density skin marker comprises a plurality of shades.

The present invention provides methods for diagnosing melanoma and / or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and / or dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

A multi-density skin marker for medical imaging exams is provided. The skin marker contains a multi-density imaging body. In one embodiment, a multi-density skin marker includes a marker substrate and a multi-density imaging body supported by the marker substrate. The multi-density imaging body comprises a first portion having a first radiographic density and a second portion having a second radiographic density. The two radiographic densities differ, such that a radiographic image of the multi-density skin marker comprises a plurality of shades.

Automated spine localizing, numbering and autoprescription system enhances correct location of diseased or injured tissue, even allow multi-spectral diagnosis. Externally located this tissue is facilitated by an integrated self adhesive spatial reference and skin marking system that is designed for a variety of modalities to include MRI, CT, SPECT, PET, planar nuclear imaging, radiography, XRT, thermography, optical imaging and 3D space tracking. The device ranges from a point localizer to a more multifunctional and complex grid / phantom system. The specially designed spatial reference(s) is affixed to an adhesive strip with corresponding markings so that after applying the unit to the skin / surface and imaging, the reference can be removed leaving the skin appropriately marked. The localizer itself can also directly adhere to the skin after being detached from the underlying strip. A spine autoprescription process performs image analysis that is able to identify vertebrae and discs even in the presence of abnormalities.

The present invention provides non-invasive methods for detecting, monitoring, and diagnosing skin disease and pathological skin states such as irritated skin and psoriasis. The methods include using tape stripping to analyze expression in epidermal samples, of one or more skin markers. In illustrative examples, the tape stripping is performed using pliable tape that has a rubber adhesive. Furthermore, the present invention provides methods for predicting and monitoring response to therapy for a skin disease, such as psoriasis or dermatitis. Finally, the methods can include the use of a microarray.

An image guided biopsy grid markable with marking medium for marking a subject's skin underlying the grid with a marking to identify a needle entry target. The grid includes a flexible substrate and a plurality of substrate pores extending therethrough. An adhesive layer on the underside of the substrate conformingly and removably attaches the substrate to the skin substantially without gapping therebetween. The adhesive layer defines a plurality of adhesive pores and / or adhesive free spaces that allow marking medium to flow through the adhesive layer and onto the skin to mark the skin and identify the needle entry target. The biopsy grid may be marked substantially anywhere along its upper surface and marking medium will pass therethrough and mark the skin.

A high accuracy image matching apparatus and a high accuracy image matching method using a skin marker and a feature point in a body, which uses ultrasonic probe or a radiation probe as a portion of the marker for image matching, are disclosed. As an embodiment, the high accuracy image matching apparatus and the high accuracy image matching method using a skin marker and a feature point in a body, use the ultrasonic probe or the radiation probe as a portion of marker for image matching indicating an anatomical feature point to reduce an error in operation point, and more precise operation can be possible and better operation result can be obtained by using the ultrasonic probe or a radiation probe.

The present invention provides methods for diagnosing melanoma and / or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and / or dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

A surgical skin marker has a handle body and a removably attached marking tip that is provided in a protective sterilized bag. After a single use, the marking tip can be removed and discarded. A new marking tip can be attached for a subsequent surgical procedure or treatment. Such a marker can help maintain a sterile surgical environment while minimizing waste and costs.

The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample and compare them with a known skin age index. Therapeutic and cosmetic formulations are also provided herein.

The present invention provides methods for diagnosing melanoma and / or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and / or dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample

A surgical skin marker has a handle body and a removably attached marking tip that is provided in a protective sterilized bag. After a single use, the marking tip can be removed and discarded. A new marking tip can be attached for a subsequent surgical procedure or treatment. Such a marker can help maintain a sterile surgical environment while minimizing waste and costs.

The invention discloses a thoracic tumor radiotherapy facilitating combined type positioning rack device. According to the upper portion of the thoracic tumor radiotherapy facilitating combined type positioning rack device, a support plate and armrests are arranged at the top; two side baffles are connected to both sides of an inclined plate; a pillow box is arranged in the middle of the inclined plate, the lower edges of the pillow box and the inclined plate are aligned; a soft plastic material base is arranged at the bottom. The thoracic tumor radiotherapy facilitating combined type positioning rack device can avoid random deviation of skin markers and ensure high repeatability and consistency of the skin positioning marker and is applied to limiting and fixing the thoracic position of a thoracic tumor patient during radiotherapy.

A one-time skin marking system and method. The system includes a marking implement with a hollow body portion and a marking tip extending therefrom. When liquid contained in the hollow body portion is introduced to the tip, the marking implement is used to mark a surgical site and then discarded. The marking liquid is indelible and has a volume not greater than an amount substantially equal to the liquid carrying capacity of the marking tip.

A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and / or hydration and / or radiopaque and / or radio luminescent and / or radioactive properties for detection by X-ray and / or Computer Tomography (CT) and / or MRI and / or Ultrasonic scanning processes and / or Positron Emission Tomography (PET), and one or more markings recognizable by an optical imaging process such as 3D surface scanning.

The invention relates to the technical field of medical products, in particular to a medical skin marker. The medical skin marker comprises marker body formed by a cap, a nib and a holder, the markerbody is internally provided with an inner core, and one end of the nib is inserted into the inner core filled with gentian violet ink. The gentian violet ink is at least prepared from gentian violet,potassium sorbate, 4-tert-butylcyclohexanol, white oil, L-arginine, cyclodextrin, alcohol with 2-6 carbon atoms and distilled water.

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

The invention provides a method and device for the treatment of scaphoid fracture in the technical field of medical treatment. The method includes the following steps that a wrist fixation base is used for fixing wrist joints to the dorsal extension position, and carpalbone-navicular bone joints are determined and labeled; a sterilized auxiliary treatment device is connected to the wrist fixationbase; a 1cm transverse incision is formed at the labeling position of the skin, subcutaneous tissue is separated until the gap of the carpalbone-navicular bone joints is reached; a bone hook hooks a navicular bone and pries the navicular bone toward the radial side, and a guide sleeve pierces the distal-pole surface of the navicular bone so as to lock the device; the angle of the guide sleeve is adjusted; the direction of the sleeve is determined through a photoscopy, and it is ensured that a guide needle can be correctly inserted inside; an anti-rotation kirschner pin is inserted along the guide needle, and the auxiliary treatment device is removed; the guide needle is inserted in the distal end of the radius through drilling, and a hollow drill is used for passing through the guide needle for drilling; a double-head compression screw passes through the guide needle and is screwed into the navicular bone; the position of the screw is determined again through photoscopy, the anti-rotation kirschner pin is pulled out, bleeding is stopped, and a wound is sutured. The method and the device ensure accurate needle insertion, and the number of the times of needle insertion and the numberof the times of photoscopy are reduced.

The invention relates to an invisible skin marker based on a rare earth up-conversion material, the marker is mainly prepared from an amine polymer modified manganese, ytterbium and erbium doped sodium yttrium tetrafluoride (NaYF4: Yb, Er, Mn) rare earth up-conversion material and a solvent, when the marker is coated or sprayed on the surface of the skin of a specific target, the marker is invisible under visible light, and the marker can be applied to the skin of the specific target. Manual removal of the marker can be avoided; and the marker displays strong fluorescence under near-infrared exciting light, has good anti-interference performance and washing resistance, and can provide a basis for identifying and recognizing suspects. The problems that part of existing markers do not have mark concealment and are not easy to mark for a long time, and the mark fluorescence color is easily interfered by the environment are effectively solved. The marker provided by the invention has good stability, anti-interference performance and relatively strong washing resistance.

Disclosed herein are various needle penetration preparation devices and methods in which each of the devices have a skin marking mechanism at one end of the device body, a sterilization applicator at another end of the device body, and a compromisable sterilization solution reservoir adjacent to the sterilization applicator.

The invention relates to the technical field of tactile sensors, in particular to a tactile fingertip sensor and an operating system and a data processing method.The tactile fingertip sensor comprises a tactile skin, a mark array sticker and a monocular camera, the mark array sticker is pasted on the inner side of the tactile skin, and the bottom of the tactile skin and the bottom of the tactile fingertip sensor form a hollow cavity; the monocular camera is installed at the bottom of the touch fingertip sensor and located in the hollow cavity, and the vision field of the monocular camera covers the inner side of the touch skin. According to the touch fingertip sensor disclosed by the invention, when a mechanical finger wearing the sensor touches an object, the sensor shoots an internal mark array image through the monocular camera, inputs the internal mark array image to the upper computer for image processing and data analysis, and finally converts the internal mark array image into various touch information; comprise the deformation condition of the contact surface, the size and direction of pressure at each marked position, contact torque and the like. By means of the design, contact in different directions can be sensed, distributed touch information is provided, and it is guaranteed that the sensor is compact in structure and light in weight.

A skin patch for use on a skin portion of a subject. The skin patch includes an analyte detector that detects an analyte from perspiration. The skin patch is adapted to release a marking agent such as a dye to mark the skin portion upon detection of the analyte.