39 results about "Developmental dysplasia" patented technology

This invention provides a surgical method to treat hip diseases, including Legg-Calve-Perthes disease or developmental hip dysplasia. This method includes several surgical techniques: a transverse osteotomy of the posterior portion of supraacetabular portion, an oblique and inclined osteotomy of the anterior portion of the supraacetabulum, detachment of a bone block from iliac crest, anterolateral displacement of the distal fragment, and insertion of the bone block into the distracted space of the osteotomy site.

The present invention provides methods for diagnosing melanoma in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and / or dysplasia patient, administering an effective amount of an estrogen antagonist therapy to the patient, wherein the amount is effective to reduce cancer and dysplasia symptoms, and observing a reduction of cancer and dysplasia symptoms in the patient.

The invention provides a hip joint prosthesis and solves the problems that parts of fastening nails of bone grafts in periacetabular osteotomy interfere with a hip joint prosthesis to cause fixing inconvenience of the bone grafts or the hip joint prosthesis and further to cause the impossibility of reaching an optimum fixing position in the prior art and that an existing total hip femoral prosthesis is not applicable to all DDH (Developmental Dysplasia Of The Hip) patients. The hip joint prosthesis comprises an acetabular cup for fixing inside an acetabulum, an eccentric acetabular liner for increasing the range of motion of the hip joint prosthesis and arranged inside the acetabular cup, a ball heat playing the role of a femoral head and arranged inside the eccentric acetabular liner and a stable femoral stem for being fixed onto a cuboid and connected with the ball head. By means of the above technical scheme, the hip joint prosthesis can be arranged in the optimum fixing position and meets the requirements on prostheses required by operations of the DDH patients.

A system (40) for diagnosis and staging of early stages of cancer in the tissue of a patient is provided. The system is configured to combine information from a Polarized Light Scattering Spectroscopy measurement (70) having a first probe depth, and a Differential Path Length Spectroscopy measurement (60) having a second probe depth, wherein the second probe depth is set larger than' the first probe depth. By comparing the results of the Polarized Light Scattering Spectroscopy and Differential Path Length Spectroscopy measurements early stages of cancer, such as dysplasia may be detected. Also hyperplasia, carcinoma in situ, and carcinoma may be detected. A computer-readable medium, method and use are also provided.

The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity.

The present invention is directed to compositions and methods for use in detecting dysplasia in Barrett's esophagus.

A method for treatment of esophageal high grade dysplasia comprising the steps of: injecting HPPH in a physiologically compatible medium into a patient having high grade dysplasia tissue to provide a dose level of 3 through 5 mg / m<2> of body surface area, waiting for a time period of 24 through 60 hours to permit preferential absorption of the HPPH into esophageal cancer tissue, and exposing the esophageal cancer tissue to light at a wavelength of about 670 +- 5 nm at an energy of from about 75 to about 200 Joules / cm.

The invention discloses a DDH (Developmental Dysplasia of Hip) osteotomy guide plate. The DDH osteotomy guide plate comprises a fixed end and a rotary end, which are fitted onto the surface of a bone of an osteotomy region; the fixed end is connected with the rotary end through a connecting module. According to the DDH osteotomy guide plate, the surgical precision can be improved by adopting the osteotomy guide plate; surgical steps in a surgery are simplified and the surgical time is shortened; a doctor does not need to judge a correction angle by experience in an orthopedic osteotomy surgery, so that the accuracy is improved and surgical risks are reduced. Meanwhile, the demand threshold on experience of doctors by the surgeries is reduced. The invention provides a manufacturing method of the DDH osteotomy guide plate; the osteotomy guide plate can be accurately and conveniently manufactured by adopting the manufacturing method. The invention provides an application method of the DDH osteotomy guide plate and the surgical time can be shortened by the method.

The invention relates to a novel application of Lnc RNA H19 (long non-coding ribonucleic acid H19), that is, overexpression of Lnc RNA H19 can delay the progression of disease from DDH (developmental dysplasia of hip) to osteoarthritis. The application has the advantages that the research of 7 cases of DDH cartilage tissue and 6 cases of cartilage tissue of fractured femoral neck shows that the expression of Lnc RNA H19 in DDH is remarkably reduced compared with that of Lnc RNA H19 in femoral neck fracture, and H19 is possible to have a relation with occurrence and development of DDH; DDH is accelerated to deteriorate into osteoarthritis if H19 is knocked down; the expression of H19 can be promoted through transfection of a slow virus LV-H19, and the overexpression of H19 can delay the progression of disease from DDH to osteoarthritis.

The present invention comprises, without limitation, systems, methods, and compositions for the detection, identification, and quantification, down to the single copy level, of human papillomavirus (HPV) in biological samples, including but not limited to, mammalian body fluids and cervix scrapings, for purposes of detection, treatment and / or management of cancer and dysplasia.

In some embodiments, a method for aiding assessment of the likelihood of dysplasia or esophageal adenocarcinoma being present in a subject can include (a) providing an esophagal sample from said subject (b) determining the methylation status of (i) SLC22A18, (ii) PIGR, (iii) GJA12 and (iv) RIN2 in said sample wherein if 2 or more of said genes are methylated then an increased likelihood of presence of dysplasia or esophageal is determined. The invention also relates to apparatus for same.

A method for treatment of esophageal high grade dysplasia comprising the steps of: injecting HPPH in a physiologically compatible medium into a patient having high grade dysplasia tissue to provide a dose level of 3 through 5 mg / m2 of body surface area, waiting for a time period of 24 through 60 hours to permit preferential absorption of the HPPH into esophageal cancer tissue, and exposing the esophageal cancer tissue to light at a wavelength of about 670±5 nm at an energy of from about 75 to about 200 Joules / cm.

The present invention provides methods for identifying IBD patients with dysplasia or cancer. In particular embodiments, the methods of the invention may comprise determining the presence or level of at least one or a panel of miRNAs in a sample obtained from an IBD patient to establish a miRNA expression profile, and comparing the miRNA expression profile with one or more pre-established model miRNA expression profiles. The present invention further provides methods for monitoring the efficacy of treatment of IBD patients with dysplasia or cancer.

The present invention is directed to EGFR-specific peptide reagents, methods for detecting pre-cancer, early cancer and / or cancer using the peptide reagents, and methods for targeting pre-cancer cells, early cancer cells and / or cancer cells using the peptide reagents. In one aspect, the disclosure provides reagents consisting essentially of a peptide QRHKPRE (SEQ ID NO: 1), HAHRSWS (SEQ ID NO: 2), YLTMPTP (SEQ ID NO: 3), TYPISFM (SEQ ID NO: 4), KLPGWSG (SEQ ID NO: 5), IQSPHFF (SEQ ID NO: 6), YSIPKSS (SEQ ID NO: 7), SHRNRPRNTQPS (SEQ ID NO: 8), NRHKPREKTFTD (SEQ ID NO: 9).

The invention belongs to the technical field of medical instruments, and discloses a double-acting full hip acetabular prosthesis with a clasp, which is used for solving the problems of high risk of hip dislocation due to developmental dysplasia of the hip, bone loss, joint or soft tissue relaxation. The structure from the outside to the inside includes: 1) an outer cup (requiring 3 acetabular screws or not requiring 3 acetabular screws); 2) an lining A, wherein the 1) outer cup and the 2 lining A form strong fixing cooperated with conicity, no relative movement is generated, that is, no jointsurface is generated, and the 2) lining A has a hemispherical inner ball joint surface; and a 4 lining B (a 6 lining inlaid with a 5 metal shell), wherein the 5 metal shell has a hemispherical outerball joint surface, and the 7) clasp. The inner ball joint surface of the lining A forms an outer joint with the outer spherical joint surface of the 5 metal shell, the inner spherical joint surface of the 6 lining and the outer spherical joint surface of the small spherical head form the inner joint, and the inner and outer joints form the double-acting total hip acetabular prosthesis featuring adouble lining and a double articular surface. The 7) clasp is placed in the 6 lining, which has anti-dislocation effect on the small ball head. The acetabular prosthesis is easy to install and can increase the mobility of the prosthesis, which can prevent acetabular dislocation, and reduces wear rate.

The invention discloses a pharmaceutical composition for preventing ONFH (Osteonecrosis of Femoral Head) after a child DDH (Developmental Dysplasia of Hip) operation, relating to the technical field of traditional Chinese medicine. The pharmaceutical composition for preventing ONFH after DDH operation is prepared from traditional Chinese medicinal materials in parts by weight of: 15-30 parts of achene of great burdock and 8-13 parts of ligusticum wallichii. The pharmaceutical composition cooperates with an operation to treat the DDH, so that the pharmaceutical composition can prevent occurrence of ONFH efficiently, achieves exact curative effects and is worth popularizing clinically.

The invention provides a hip joint prosthesis and solves the problems that parts of fastening nails of bone grafts in periacetabular osteotomy interfere with a hip joint prosthesis to cause fixing inconvenience of the bone grafts or the hip joint prosthesis and further to cause the impossibility of reaching an optimum fixing position in the prior art and that an existing total hip femoral prosthesis is not applicable to all DDH (Developmental Dysplasia Of The Hip) patients. The hip joint prosthesis comprises an acetabular cup for fixing inside an acetabulum, an eccentric acetabular liner for increasing the range of motion of the hip joint prosthesis and arranged inside the acetabular cup, a ball heat playing the role of a femoral head and arranged inside the eccentric acetabular liner and a stable femoral stem for being fixed onto a cuboid and connected with the ball head. By means of the above technical scheme, the hip joint prosthesis can be arranged in the optimum fixing position and meets the requirements on prostheses required by operations of the DDH patients.

In some embodiments, a method for aiding assessment of the likelihood of dysplasia or esophageal adenocarcinoma being present in a subject can include (a) providing an esophagal sample from said subject (b) determining the methylation status of (i) SLC22A18, (ii) PIGR, (iii) GJA12 and (iv) RIN2 in said sample wherein if 2 or more of said genes are methylated then an increased likelihood of presence of dysplasia or esophageal is determined. The invention also relates to apparatus for same.

The invention discloses a hip joint standard ultrasonic image acquisition method based on a Graf ultrasonic technology and an intelligent system, and relates to an intelligent medical equipment system, in particular to an early screening technology for infant developmental dysplasia of joints. The method comprises the following steps: 1) establishing a picture substrate with a baseline; 2) presetting an identification area and an identification condition on the picture substrate; 3) acquiring an online ultrasonic image, and comparing and judging the online ultrasonic image with the preset identification area and the preset identification condition on the picture substrate; and 4) generating a standard image which can be used for measurement by using the online ultrasonic image which falls into the preset identification area and meets the preset identification condition. In the step 1), the ratio of the width to the height of the picture substrate is 1: (1-1.3), and a base line is arranged in the range of 10-20% of the width size of the two sides of the central point in the longitudinal direction of the picture substrate. According to the method, errors in screening can be effectively avoided, and the screening accuracy and efficiency are greatly improved.

The invention relates to an assembled cementless femoral component prosthesis suitable for Chinese DDH (Developmental Dysplasia of Hip) patients. The assembled cementless femoral component prosthesis consists of a sleeve cover b and a femoral component body, wherein the femoral component body consists of a prosthesis neck a and a prosthesis handle c; the sleeve cover b sleeves the prosthesis handle c. The assembled cementless femoral component prosthesis is characterized in that a thick cylinder c1 adjacent to the prosthesis neck is arranged on the prosthesis handle c; a reverse cone frustum c2 and a fine cylinder c3 are in sequential and downward arrangement; the diameter of the thick cylinder c1 is identical to the upper bottom diameter of the reverse cone frustum c2; the lower bottom diameter of the reverse cone frustum c2 is identical to the diameter of the fine cylinder c3; the sleeve cover b comprises a sleeve cover near end b1 and a sleeve cover remote end b2; the sleeve cover near end b1 is a hollow cylinder; the sleeve cover remote end b2 is a hollow reverse cone frustum; the outer diameter of the hollow cylinder equals to the upper bottom outer diameter of the hollow reverse cone frustum; the inner diameter of the hollow cylinder equals to the inner diameter of the upper bottom surface of the hollow reverse cone frustum. The problem that the existing assembled prosthesis cannot realize effective matching with the femoral medulary cavity of Chinese DDH patients is solved.

Some embodiments are directed to a method of aiding the diagnosis of dysplasia in a subject that includes providing a sample from the oesophagus of the subject; assaying the sample for expression of each of the genes shown in the ‘40 genes’ column of Table 1; normalising the expression levels of the genes in step (b) to expression levels of reference gene(s) from a non-dysplastic sample; and determining from the normalised expression levels of step (c) a gene signature score for the sample, wherein a gene signature score greater than a reference threshold indicates presence of dysplasia in the subject. Some embodiments also relate to devices, compositions, primer sets, arrays, methods of treatment and computer programs.

The invention discloses a DDH (Developmental Dysplasia of Hip) osteotomy guide plate. The DDH osteotomy guide plate comprises a fixed end and a rotary end, which are fitted onto the surface of a bone of an osteotomy region; the fixed end is connected with the rotary end through a connecting module. According to the DDH osteotomy guide plate, the surgical precision can be improved by adopting the osteotomy guide plate; surgical steps in a surgery are simplified and the surgical time is shortened; a doctor does not need to judge a correction angle by experience in an orthopedic osteotomy surgery, so that the accuracy is improved and surgical risks are reduced. Meanwhile, the demand threshold on experience of doctors by the surgeries is reduced. The invention provides a manufacturing method of the DDH osteotomy guide plate; the osteotomy guide plate can be accurately and conveniently manufactured by adopting the manufacturing method. The invention provides an application method of the DDH osteotomy guide plate and the surgical time can be shortened by the method.

The invention provides a child developmental dysplasia of a hip (DDH) acetabular osteotomy orthopedic guide plate and a use method thereof. The guide plate includes an osteotomy guide plate and a downward-pressure spreading guide plate, the osteotomy guide plate has a shape that fits with a joint capsule at the outer upper part of an acetabulum and surrounding bone surfaces, and the osteotomy guide plate has a preset height of an osteotomy groove and a plurality of Kirschner pinholes; and the downward-pressure spreading guide plate is provided with two side plates and a connecting part, the two side plates are respectively arranged on two sides of the downward-pressure spreading guide plate, a tip opening shape is formed between the two side plates, the bottoms of the two side plates are connected through the connecting part, and the connecting part is connected by a bar. The orthopedic osteotomy plate system for completing osteotomy operation during orthopedic surgery and integratingpositioning, guiding and ranging and the operation method are provided in the invention, the safety and accuracy of the surgery can be improved, the surgery time can be shortened, and excessive X-rayradiation can be avoided.

The invention discloses a pharmaceutical composition for preventing ONFH (Osteonecrosis of Femoral Head) after a child DDH (Developmental Dysplasia of Hip) operation, relating to the technical field of traditional Chinese medicine. The pharmaceutical composition for preventing ONFH after DDH operation is prepared from traditional Chinese medicinal materials in parts by weight of: 15-30 parts of achene of great burdock and 8-13 parts of ligusticum wallichii. The pharmaceutical composition cooperates with an operation to treat the DDH, so that the pharmaceutical composition can prevent occurrence of ONFH efficiently, achieves exact curative effects and is worth popularizing clinically.

The invention discloses a manufacturing method of a personalized absorbable support bone grafting plate for developmental dysplasia of the hip. The manufacturing method comprises the following steps of generating contour lines of all layers of a bone wheel and contour lines of cancellous bones through CT scanning data, further obtaining cortical bone and cancellous bone three-dimensional models, and constructing a support bone grafting plate 3D model according to the damage conditions of the cortical bone and cancellous bone three-dimensional models. and carrying out 3D printing post-treatmentto obtain the support bone grafting plate. Some examples of the invention can satisfy the coverage of the outer side, the front and the rear of the acetabulum, avoid excessive coverage, reconstruct the normal mechanical conduction of the hip joint, effectively relieve cartilage wear caused by stress concentration, and have a wide clinical application prospect.

The present invention relates to the application of semi-solid composition and semi-solid pharmaceutical product in photodynamic therapy (PDT) cancer, precancerous lesion and noncancerous lesion of female reproductive system, anus and penis, especially suitable for endometrium, cervix, vulva , developmental abnormalities of the vagina, anus, and penis, and PDT for HPV infection of the uterus, cervix, vulva, vagina, anus, and cervix. The semi-solid composition and pharmaceutical product contain an active ingredient, which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or a pharmaceutically acceptable salt thereof. The present invention also relates to a PDT method for the treatment of cancerous, precancerous and noncancerous lesions of the female reproductive system, anus and penis, wherein said semisolid composition and pharmaceutical preparation are used.

The embodiment of the invention discloses a method and system for measuring the coverage rate of a cartilage head cotyle in front of a hip joint and application of the method and system. The method comprises the steps of determining a scanning range of an oblique sagittal plane of a high-resolution fat suppression proton density weighted image of a unilateral hip joint based on coronal plane and axial plane magnetic resonance scanning images of double hip joints of a measured object; acquiring an oblique sagittal plane magnetic resonance scanning image of the high-resolution fat suppression proton density weighted image of the unilateral hip joint based on the scanning range of the oblique sagittal plane; based on the oblique sagittal plane magnetic resonance scanning image, the distance from the front edge of the acetabular cartilage to the rear edge of the femoral head cartilage and the maximum front-back diameter of the femoral head are obtained; and taking the ratio of the distance from the front edge of the acetabular cartilage to the rear edge of the femoral head cartilage to the maximum front-back diameter of the femoral head as the coverage rate of the cartilage head cotyle in front of the hip joint. According to the technical scheme, the detection accuracy of the developmental dysplasia of the hip joint can be improved.

Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are demonstrated to be detectable in the urine of animals having colorectal cancer, and a diagnostic / screening method for identifying and / or detecting colorectal cancer in an animal from a urine sample is provided. Specific tissue immunohistochemcial staining for catE (monomeric forms) in dysplastic tissue is also disclosed, and is shown to correlate with the level of dysplastic lesion severity. Hence, a method for identifying and determining the level of dysplastic lesion severity is provided. Cathepsin E mRNA transcription and expression levels are also demonstrated to be upregulated in dysplastic tissue, relative to non-dysplastic tissue. Hence, a method for transcriptionally profiling an animal to monitor the progression of colorectal disease is provided.

The invention discloses an eye patch applied to juvenile glaucoma. The eye patch sequentially consists of a transparent protection layer, a traditional Chinese medicine layer, a gel layer and a non-woven fabric layer from top to bottom, wherein the medicine layer is prepared from traditional Chinese raw materials in parts by weight: 3 to 10 parts of antelope's horn powder, 15 to 25 parts of chrysanthemum flowers, 10 to 20 parts of schisandra chinensis, 20 to 30 parts of cassia seeds, 20 to 30 parts of semen plantaginis, 10 to 20 parts of wine-treated rhubarb, 15 to 25 parts of wine-treated scutellaria baicalensis, 8 to 15 parts of radix paeoniae alba, 7 to 10 parts of borneol, 7 to 10 parts of menthol, 10 to 20 parts of purple yam extracts, 3 to 10 parts of grape seed extracts, 3 to 10 parts of lavender extracts and 5 to 10 parts of glycerol. The eye patch applied to juvenile glaucoma is characterized in that according to the condition that the congenital angulus iridocornealis development abnormality is caused by aqueous fluid circulation impediment, the cornea is wide; the pigment in the iris and trabecula positions is deposed; the eye patch suitable for juvenile glaucoma is prepared; the structure combination design is scientific; the medicine power is directly conducted; the eye patch is externally pasted for skin absorption; the eye blood circulation is improved; the eye pressure is reduced; the symptoms of eye fatigue, conjunctival congestion, eye itching and the like are relieved; the glaucoma is further prevented.