31results about How to "Early stage" patented technology

The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest.

An ECU executes a program including the steps of: detecting a distance to an object; changing over a changeover damper from an inside air circulation to an outside air circulation when a collision is predicted; controlling a power window device to move down a door glass; turning an SMR off when the collision is detected; and controlling the power window device to fully open the door glass.

A control device of the present invention includes: a face position detecting section for detecting a position of a user's face in an image captured by a capturing device; a face recognition processing section for checking a partial image against reference face images, the partial image being at the position detected in the captured image, and extracting a reference face image that matches the face in the partial image; a user authentication section for specifying a user name that corresponds to the extracted reference face image; and a data checking section for (i) checking whether or not a multifunction printer receives print data added with the specified user name, and (ii) if it is confirmed that the multifunction printer receives the print data, operating an image forming section of the multifunction printer to form an image based on the print data. This realizes a control device which (i) authenticates a user in an easy way in which impersonation can be prevented without inconvenient operation, and (ii) prevents another user from accidentally viewing a printed matter.

An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity.According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.

This patent describes a method and materials to treat cancer diagnosed at an early stage, particularly breast cancer. It considers that metastatic breast cancer growth includes periods of dormancy, that surgery to remove a primary tumor can induce metastatic growth, and that women with Down Syndrome rarely get breast cancer. It elevates the level of an antiangiogenic drug produced by chromosome 21 preferably Endostatin in plasma preferably at least one day prior to surgery and kept at that high level preferably indefinitely. The therapy specifically excludes drugs that significantly inhibit the VEGF pathway since that is important for wound healing. This method will prevent results of surgery from stimulating tumor growth and angiogenesis of micrometastatic disease that is much easier to prevent than control after the fact. This can be done indefinitely since there is no acquired resistance that develops, as happens in most cancer therapies.

There are provided an information recording / reproducing apparatus and a video camera, both compliant with plural standards and excellent in usability, within an advantageously earlier stage by simplifying a circuit configuration and reducing the development steps and time period. A compression / extension module includes a common compression / extension module which performs a process of a compression method common in plural standards. For example, the common compression / extension module common between the AVCHD standard and the BD standard performs a process of the H.264 compression method for a video signal, and performs a process of the Dolby Digital compression method for an audio signal. A format controlling module includes a common format generating module which performs a formatting process common in plural standards. For example, the common format generating module common between the AVCHD standard and the BD standard generates a format including data structures and directories, in compliance with the BDMV subset.

A wafer for forming an imaging element has a test pattern and a plurality of imaging element units. The wafer has an imaging region which includes a great number of photoelectric conversion pixels, an imaging element units and a test pattern. The test pattern includes a testing organic photoelectric conversion film and a testing counter electrode having the same configuration and formed at the same time as the organic photoelectric conversion film and a counter electrode, respectively of the photoelectric conversion pixels. A first testing terminal is electrically connected to the undersurface side of the testing organic photoelectric conversion film, and a second testing terminal is electrically connected to the testing counter electrode. A protective film is formed over the entire semiconductor wafer so as to cover the imaging region and the test pattern, and is then partially removed so that a part of each testing terminal is exposed.

Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression.

Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression.

A method and a kit for the prevention of venous stenosis associated with the use of hemodialysis AV shunts. The kit may use a bifurcated needle for providing access to the shunt or blood vessel. One of the arms is used for returning the blood to the subject after dialysis treatment, while the other arm is used for inserting a device for cleaning the vein, the device being either an autonomous crawling device, or a passive tethered device moved down the vein by the blood flow. The autonomous crawling device may be a series of sequentially inflatable chambers, the stenosis being cleared by pressure from the outer walls of the chambers when inflated and moved. The passive device may be an element having a flexible disc-like structure, whose flexible peripheral edge slides along the inner walls of the blood vessel, compressing or clearing the material attached thereto.

A system (40) for diagnosis and staging of early stages of cancer in the tissue of a patient is provided. The system—is configured to combine information from a Polarized Light Scattering Spectroscopy measurement (70) having a first probe depth, and a Differential Path Length Spectroscopy measurement (60) having a second probe depth, wherein the second probe depth is set larger than' the first probe depth. By comparing the results of the Polarized Light Scattering Spectroscopy and Differential Path Length Spectroscopy measurements early stages of cancer, such as dysplasia may be detected. Also hyperplasia, carcinoma in situ, and carcinoma may be detected. A computer-readable medium, method and use are also provided.

The present invention relates to a biomarker associated with a cancer and a method using the biomarker to evaluate a risk of proliferation, invasion, or metastasis of a cancer. The method of the present invention comprises the following steps: (A) providing a tissue sample to evaluate for risk of proliferation, invasion, or metastasis of a cancer, wherein the tissue sample comprises a non-cancer region, and a suspected cancer region; (B) detecting expression levels of a biomarker and a predetermined standard in the non-cancer region and the suspected cancer region respectively, wherein the biomarker is T-cell lymphoma invasion and metastasis 2 (TIAM2); (C) comparing the expression levels of the biomarker and the predetermined standard in the non-cancer region to the expression levels of the biomarker and the predetermined standard in the suspected cancer region.

A decision feedback equalizer for generating an output signal according to an input signal includes: a feedforward equalizer, a feedback equalizer and a weight coefficient control unit. The feedforward equalizer includes a plurality of tapped delay lines and is controlled by a set of first weight coefficients. The feedback equalizer includes a plurality of tapped delay line and is controlled by a set of second weight coefficients. The weight coefficient control unit is employed to selectively adjust at least one of the set of first weight coefficients and determine a set of first boundary values for at least one of the set of second weight coefficients. When the at least one of the set of second weight coefficients does not exceed the set of first boundary values, the weight coefficient control unit increments the at least one of the set of first weight coefficients.

A rapidly dehydrating fluid (RDF) composition that forms a permeable and decomposable plug and methods of lost circulation control and manufacture of the RDF composition. The RDF composition may include a carrier fluid such as water, a cellulosic microfiber viscosifier, date tree seed particles, and fibers formed from date tree waste such as date tree trunks. The RDF composition may mitigate or prevent lost circulation by forming a decomposable plug in a fracture of the lost circulation zone and may also enable the production of hydrocarbons from the zone without removal of the plug.

In a vehicle seat, a gas generating device of a side airbag apparatus is attached to the inside of an outer side frame in a seat-width direction. When a seated occupant is a three-dimensional mannequin of AM50, a portion of the gas generating device overlaps a back pan of the three-dimensional mannequin as viewed in a seat front-rear direction. Here, in a plan section of a seat back in a range in which the gas generating device is positioned in a seat up-down direction, when an imaginary line overlapping a section of the back pan is moved back toward a seat rear side until the imaginary line comes into contact with a side spring portion of a seat back spring, the gas generating device is positioned rearward of a moved-back imaginary line in the seat front-rear direction and outward of the moved-back imaginary line in the seat-width direction.