31results about How to "Suppress growth" patented technology

A method for producing a cathode material for a secondary battery, characterized in that it comprises admixing a compound liberating a phosphate ion in a solution (phosphoric acid H3PO4, phosphorus pentoxide PO5, ammonium dihydrogenphosphate NH4H2PO4 and the like), water and metallic iron, adding lithium carbonate, lithium hydroxide or a hydrate thereof to the resultant mixture, and firing the resultant reaction product , to thereby synthesize LiFePO4.

The present invention relates to a compound represented by the formula wherein A is a benzene ring optionally having substituents, R1, R2a and R3 are each a hydrogen atom, a hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, R1 and R2a may form a ring via X, when R1 and R2a form a ring via X, R1 and R2a are each a bond or a divalent C1-5 acyclic hydrocarbon group optionally having substituents, and X is a bond, an oxygen atom, an optionally oxidized sulfur atom or an imino group optionally having a substituent, provided that R1, R2a and X are not bonds at the same time, or a salt thereof, and an agent for inhibiting kinase (phosphorylation enzyme), which contains this compound or a prodrug thereof. The compound of the present invention has an inhibitory activity against kinase such as a vascular endothelial growth factor receptor (VEGFR) and the like, and is useful as an agent for the prophylaxis or treatment of cancer and the like.

A semiconductor device includes: a semiconductor substrate; a semiconductor element formed on the semiconductor substrate and containing a gate electrode; impurity diffusion layers formed at both sides, in a cross-section in a gate length direction of the gate electrode, of a region on which the semiconductor element is formed of the semiconductor substrate; first silicide films formed respectively at the surface of the impurity diffusion layers, composed of a silicide compound of a first metal; and a second silicide film, formed at least at the surface of the gate electrode, composed of a silicide compound of a second metal different to the first metal. The silicide compound of the second metal has a silicidation temperature lower than the silicidation temperature of the silicide compound of the first metal.

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer, as well as other types of malignancy, including brain metastases of NSCLC. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and tyrosine kinase inhibitors; the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.

A semiconductor device includes a ferroelectric capacitor formed above the lower interlevel insulating film covering a MOS transistor formed on a semiconductor substrate, including lamination of a lower electrode, an oxide ferroelectric film, a first upper electrode made of conductive oxide having a stoichiometric composition AOx1 and an actual composition AOx2, a second upper electrode made of conductive oxide having a stoichiometric composition BOy1 and an actual composition BOy2, where y2 / y1>x2 / x1, and a third upper electrode having a composition containing metal of the platinum group; and a multilayer wiring structure formed above the lower ferroelectric capacitor, and including interlevel insulating films and wirings. Abnormal growth and oxygen vacancies can be prevented which may occur when the upper electrode of the ferroelectric capacitor is made of a conductive oxide film having a low oxidation degree and a conductive oxide film having a high oxidation degree.

A vane structure for an axial flow turbomachine that has: a single-vane section of a one-vane structure formed in a part in a vane radial direction; and a tandem-vane section which is formed in a remaining part in the vane radial direction continuously with the single-vane section, and which includes a front vane and a rear vane arranged forward and backward with respect to an airflow that flows through a flow path, respectively.

The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest.

A negative electrode for a lithium metal battery, a method for manufacturing the same, and a lithium metal battery having the same. Formation of lithium dendrite may be prevented by forming a dielectric layer on the surface of lithium metal, and thus improve lifespan characteristics and electrochemical performance when applied to a lithium metal battery.

The present teaching provides a nonaqueous electrolytic solution secondary battery in which both a satisfactory high-rate characteristic and a high cycle characteristic (prevention of decrease in capacity) are realized. The nonaqueous electrolytic solution secondary battery of the present teaching includes a positive electrode provided with a positive electrode active material layer, a negative electrode provided with a negative electrode active material layer, and a nonaqueous electrolytic solution. The negative electrode active material layer includes a negative electrode active material and carbon black. A coating film made of a lithium transition metal composite oxide having lithium ion conductivity is formed on at least part of a surface of the carbon black.

The present invention provides: a skin protection composition that can effectively suppress intrusion of contagious bacteria such as Pseudomonas aeruginosa, Bacillus subtilis, Bacillus anthracis, Escherichia coli, Staphylococcus aureus, or MRSA, and viruses such as influenza virus from wounds, skin and mucosa such as those of the eyes, nose, throat, ears, anus and vagina into the body, and can also suppress growth of the bacteria and viruses; a skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria; a composition to prevent and / or treat bacterial and viral infections including hospital infections; an antiseptic; and a filter apparatus that can effectively suppress intrusion into the body and growth therein of contagious bacteria and viruses. The skin protection composition; skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria; composition to prevent and / or treat bacterial and viral infections including hospital infections; antiseptic; and filter apparatus that can effectively suppress intrusion into the body of contagious bacteria and viruses characterized by comprising Sasa extract, or Sasa extract and an organic acid as the active component.

The use of camptothecin (CPT), hyperoside and / or trifolin in preventing or inhibiting the growth of fungal pathogens, including molds.

The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and / or an anti-biofilm / or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.

Provided is a pneumatic radial tire for a light truck which is designed to improve the contact shape, to suppress the growth and strain of a belt edge portion due to the creep strain of a carcass layer, and to prevent the separation failure at the belt edge portion. The pneumatic radial tire of the present invention is one, in which a carcass layer is formed of organic fiber cords, the tire has a casing structure in which at least two belt layers are disposed on a radially outer side of the carcass layer, and an air pressure corresponding to the maximum load carrying capacity is in the range of 350 to 650 kPa, wherein a belt cover layer is disposed around an edge portion of the belt layer, the belt cover layer comprising an organic fiber cord wound around the tire in a circumferential direction of the tire, the organic fiber cord having an intermediate elongation of at most 5.5% under a load of 67 N.

The invention provides compositions comprising flagellin polypeptides from bacterial strains and the use of such compositions in the treatment of disease.

A semiconductor device includes a ferroelectric capacitor formed above the lower interlevel insulating film covering a MOS transistor formed on a semiconductor substrate, including lamination of a lower electrode, an oxide ferroelectric film, a first upper electrode made of conductive oxide having a stoichiometric composition AOx1 and an actual composition AOx2, a second upper electrode made of conductive oxide having a stoichiometric composition BOy1 and an actual composition BOy2, where y2 / y1>x2 / x1, and a third upper electrode having a composition containing metal of the platinum group; and a multilayer wiring structure formed above the lower ferroelectric capacitor, and including interlevel insulating films and wirings. Abnormal growth and oxygen vacancies can be prevented which may occur when the upper electrode of the ferroelectric capacitor is made of a conductive oxide film having a low oxidation degree and a conductive oxide film having a high oxidation degree.

This invention is to provide microbial pesticides that can control plant disease damages by spraying the microbial pesticides, which contain filamentous fungus Verticillium lecanii having suppressant effect on the growth of plant pathogen, onto plants such as fruits and vegetables, and to provide soil borne improvement agents which contain filamentous fungus Verticillium lecanii, and exert effect on improving the soil borne by applying to soil borne. By applying filamentous fungus Verticillium lecanii, preferably strains having an ability of colonization on plant surface, and / or strains having an ability of colonization on plant root surfaces and / or in rhizosphere to plants as microbial pesticides, the growth of plant pathogens as well as insect pests adhering to plants can be significantly suppressed. Furthermore, by giving them to soil borne, the growth of pathogens in plant rhizomes and the rhizosphere thereof can be suppressed, and pathogens are not developed in the soil borne even after the transplantation, therefore, the soil borne can be improved.

The present invention provides a method comprising suppressing the growth of a microorganism selected from the group consisting of anthrax bacteria and a virus selected from the group consisting of herpes simplex virus and influenza virus by providing an object containing or impregnated with a composition comprising Sasa extract, and bringing the microorganism into contact with the composition.

A pneumatic tire includes a tread section, a bead section, and a sidewall section. The sidewall section is provided in a predetermined region in a tire radial direction with: a first decorative section provided with a serration section including ridges protruding on an external surface of the sidewall section, the ridges being disposed adjacent to each other in a tire circumferential direction; a second decorative section disposed adjacent to an end portion of the first decorative section in the tire circumferential direction and being provided with a serration section including ridges protruding on the external surface, the ridges being disposed adjacent to each other in the tire circumferential direction; and a recessed section disposed adjacent to the second decorative section and being recessed inward from the second decorative section in the tire radial direction.

The present invention relates to compositions and methods for treating cancer by targeting the Activin signaling pathway. In certain embodiments, combining Activin blockade with immunomodulation alters regulatory T (Treg) cell-mediated immune regulation and treats cancer.

Provided are an upstream Open Reading Frame (uORF) of a Phosphatase and Tensin homolog (PTEN) gene and a protein coded by the uORF. A potential ORF of 138 bases (45aa-uORF) in the 5′UTR of the PTEN, coding an oligopeptide of 45 amino acids (named PTEN-45aa) plays an important role in the development and progression progress of tumors. Further provided are a new diagnostic and therapeutic method and a drug screening platform for PTEN expression regulation related diseases, in particular neuroglioma. Also provided is a polypeptide for treatment of PTEN expression regulation related diseases.

A pneumatic tire includes, in a tread portion, a plurality of blocks formed by a plurality of main grooves extending in a tire circumferential direction and a plurality of lateral grooves extending in a tire width direction so as to intersect the main grooves. The lateral grooves each include a reinforcement region in which a plurality of projecting portions are formed at a groove bottom. In the reinforcement region, at least one projecting portion is arranged on any line extending in the tire circumferential direction.

A lithium electrode includes a protective layer containing an ion conductive electrolyte in the interior and on the surface of the electrically conductive matrix. The protective layer may make the electrical conductivity of the surface of the lithium electrode uniform, imparts strength during the growth of lithium dendrites, physically prevents the growth of lithium dendrites, and suppresses the generation of dead lithium.

The present teaching provides a nonaqueous electrolytic solution secondary battery in which both a satisfactory high-rate characteristic and a high cycle characteristic (prevention of decrease in capacity) are realized. The nonaqueous electrolytic solution secondary battery of the present teaching includes a positive electrode provided with a positive electrode active material layer, a negative electrode provided with a negative electrode active material layer, and a nonaqueous electrolytic solution. The negative electrode active material layer includes a negative electrode active material and carbon black. A coating film made of a lithium transition metal composite oxide having lithium ion conductivity is formed on at least part of a surface of the carbon black.

According to the present invention, there is reliably provided a soy sauce having desired ethanol and lactic acid concentrations and a mellow flavor. A method of brewing soy sauce which comprises mixing soy sauce koji into a salt water to prepare a soy sauce moromi mash, adding pre-cultured soy sauce lactic acid bacteria and soy sauce yeast to the moromi mash, performing fermentation and aging of the moromi mash after adding by ordinary techniques, wherein the soy sauce yeast is added to the soy sauce moromi mash within 10 days after mixing such that the cell count of the soy sauce yeast is 10 to 100 fold greater than that of wild yeast already existing in the moromi mash and is 2×105 or less cells / g moromi mash to the soy sauce moromi mash, so that the desired soy sauce is obtained.

Provided are applications of an upstream Open Reading Frame (uORF) of a Phosphatase and Tensin homolog (PTEN) gene and a polypeptide coded by the same. A potential ORF of 96 bases (31aa-uORF) existing in the 5′ UTR of the PTEN can code an oligopeptide of 31 amino acids (named PTEN-31aa) and plays an important role in the development and progression process of tumors. Provided is a new diagnostic and therapeutic method and a drug screening platform for PTEN expression regulation related diseases, in particular gliomas. Also provided is a polypeptide for treatment of PTEN expression regulation related diseases.

The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according to the present disclosure may induce cancer cell death by damaging mitochondria and inducing ATP depletion in cells which are in a nutrient-starved state such as a glucose-starved state, which is the normal environment of cancer cells. In addition, it is an Nm23-H1 / NDPK activity-increasing substance that may suppress cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

The present inventors successfully produced therapeutic agents for non-small cell lung cancer except adenocarcinoma, comprising as active ingredient an anti-Epiregulin antibody that shows cross-species reactivity between the human animal and cynomolgus which is a non-human animal, an anti-Epiregulin antibody with suppressed chemical degradation, an anti-Epiregulin antibody with reduced isoelectric point, an anti-Epiregulin antibody with increased midpoint temperature of thermal denaturation, or an anti-Epiregulin antibody with reduced amount of aggregates, generated by appropriately substituting amino acid residues in the variable-region sequences of a humanized EP27 antibody that inhibits cancer cell proliferation by exerting a cytotoxicity and a neutralizing activity against human Epiregulin-expressing cancer cells.

A tire for a construction vehicle according to the present invention provides a tire for a construction vehicle having a belt formed by plural layers on the radially outer side of a crown portion of a carcass toroidally extending between a pair of bead portions, in whichan outermost belt layer located on the radially outermost side of the belt has a width of 50% or more of a tread width, anda narrow groove is provided such that a distance between an end portion of the outermost belt layer and a bottom portion of the narrow groove is in the range of 15% to 100% of a tread thickness T, where T is a tread thickness at the end portion of the outermost belt layer.

The invention relates to genes isolated from Arabidopsis that code for proteins essential for normal plant development. The invention also includes the methods of using these proteins to discover new herbicides, based on the essentiality of the genes for normal growth and development. The invention can also be used in a screening assay to identify inhibitors that are potential herbicides. The invention is also applied to the development of herbicide tolerant plants, plant tissues, plant seeds, and plant cells.