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Method of reducing abeta42 and treating diseases

InactiveUS20080021085A1Increased risk of developingIncreased riskBiocideNervous disorderCholinesterase inhibitionRegimen
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ38 are increased, and levels of Aβ40 are unchanged. The invention provides methods and materials for developing and identifying Aβ42 lowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of Aβ42 lowering agents and antioxidants, Aβ42 lowering agents and non-selective secretase inhibitors, as well as Aβ42 lowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and / or acetylcholinesterase inhibitors as well as instructions related to dose regimens for Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES +1

Wind power plant cluster wind speed prediction method

The invention belongs to the wind power generation technical field, and especially relates to a wind power plant cluster wind speed prediction method comprising the following steps: a wind power plant clustering step; a wind speed correlation hierarchy analysis step; an adjacent wind power plant wind speed prediction step. The wind power plant cluster wind speed prediction method is strong in operationality and practicality, accurate and reliable in prediction result, thus greatly accelerating wind power engineering progress.
Owner:STATE GRID CORP OF CHINA +1

Method of reducing Abeta42 and treating diseases

The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ38 are increased, and levels of Aβ40 are unchanged. The invention provides methods and materials for developing and identifying Aβ42 lowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of Aβ42 lowering agents and antioxidants, Aβ42 lowering agents and non-selective secretase inhibitors, as well as Aβ42 lowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and / or acetylcholinesterase inhibitors as well as instructions related to dose regimens for Aβ42 lowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES +1

Artificial half-salt water ecological breeding method of enteromorpha

The invention discloses an artificial half-salt water ecological breeding method of enteromorpha. The method comprises the following steps: (1) preparing an artificial half-salt water culture solution for later use; (2) cleaning yellow green enteromorpha for several times, sucking dry the surface moisture, and semi-drying a drying box in which samples are positioned in the shade; (3) disinfecting enteromorpha samples semi-dried in the shade in artificial salt water containing an iodine solution for several minutes, after sheared algae section treatment, putting the samples into a culture vessel containing the artificial half-salt water culture solution and an attaching substrate, and sealing by using a preservative film; (4) culturing in an illumination incubator; (5) introducing zooplanktons and adding food yeasts after divergent enteromorpha spores or gametes are fully attached to the attaching substrate, so as to form an ecological breeding system in the culture vessel. The artificial half-salt water ecological breeding method of enteromorpha disclosed by the invention is easy to operate, has the advantages of readily available raw materials, low price, low cost and extensive culture and is particularly suitable for enteromorpha-related researches in inland areas or labs.
Owner:HANGZHOU ENJOY ENVIRONMENTAL PROTECTION TECH

Method of utilizing straw to produce biomass fuel, corrugated paper and organic fertilizer

The invention relates to a method of utilizing straw to produce biomass fuel, corrugated paper and organic fertilizer. The method includes: cutting the straw, dusting through a dry process and a waterfilm, washing through hot water extraction for desanding, continuously boiling for hydrolysis, blowing and receiving, performing multistage countercurrent washing, jordaning at high concentration, treating fiber in a staged manner, concentrating long fiber, curing the long fiber, jordaning the long fiber, and using the long fiber to produce the corrugated paper; concentrating the short fiber, subjecting fine and broken fiber to enzymolysis, fermentation and distillation to produce cellulose alcohol, and separating waste mash for utilization. By the method, high-value comprehensive utilizationof each component of the straw is realized, wastewater COD biochemical degradability is high, inorganic salt accumulation is avoided, biogas is produced by high-concentration wastewater in the process and purified as natural gas, and low-concentration wastewater is recycled after being treated, so that a water system is a closed cycle, and there is no wastewater emission; a fine and broken fibercomponent is large in specific surface area and high in enzymolysis efficiency; the corrugated paper produced by a long fiber component is high in strength and quality, and cost of the cellulose alcohol can be lowered; biological natural gas and biomass particle fuel can reduce consumption of mineral fuel.
Owner:吴学军 +5

Three-cavity cervix balloon dilatation device

PendingCN107670166AIncrease strengthReduce pain timeBalloon catheterDilatorsFull Term PregnancyInjections needle
The invention discloses a three-cavity cervix balloon dilatation device. The three-cavity cervix balloon dilatation device comprises a balloon set, a rubber tube, injection ports and plugs; a first end of the rubber tube is connected with the injection ports, the balloon set is arranged at a second end of the rubber tube, and a first balloon, a second balloon and a third balloon of the balloon setare arranged at the second end of the rubber tube in sequence; the rubber tube is composed of a protective outer tube and injection inner tubes, a first fixing opening, a second fixing opening and athird fixing opening are formed in the positions, located at the first balloon, the second balloon and the third balloon, of the rubber tube respectively, wherein the first fixing opening, the secondfixing opening and the third fixing opening are connected with one ends of the three injection inner tubes respectively, the other ends of the three injection inner tubes penetrate the protective outer tube and are fixedly connected with the injection ports, and needle cores are arranged on the injection ports. According to the three-cavity cervix balloon dilatation device, the capacity of cervical dilatation can be greater improved, and the device has high use value for labor induction of a full-term pregnant woman with an extremely low cervical score or labor induction of intermediate stagepregnancy.
Owner:孙利华

Methods for producing corrugated paper, natural gas and organic fertilizer from straws

The invention discloses methods for producing corrugated paper, natural gas and organic fertilizer from straws. The method for producing the corrugated paper includes: (1) cutting the straws; (2) dedusting by a dry method; (3) dedusting by a water membrane; (4) extracting and washing with hot water to remove sand; (5) hydrolyzing by continuous steaming; (6) sprinkling and collecting; (7) backwashing in multiple stages; (8) grinding into high-concentration liquid firstly; (9) ripening; (10) grinding into high-concentration liquid and low-concentration liquid; (11) producing the corrugated paper. The method for producing the natural gas includes the steps of: (1) subjecting high-concentration wastewater to anaerobic treatment; (2) subjecting the treated wastewater to aerobic treatment; (3) purifying marsh gas obtained from anaerobic treatment to obtain the natural gas. The method for producing the organic fertilizer is also provided. The methods for producing the corrugated paper, the natural gas and the organic fertilizer from straws are environmentally friendly, the wastewater obtained in the processes can be recycled, self-producing capability of pulp for industrial packing paperincluding the corrugated paper and the like can be improved, the difficulty of fibrous material shortage in our country can be alleviated, and reliance on imported waste paper can be reduced.
Owner:吴学军 +4

Preparation methods of chitosan and organic water-soluble fertilizer thereof

The invention provides an organic water-soluble fertilizer comprising a variety of macro elements and trace elements. With the organic water-soluble fertilizer, nutrients needed by crop growth can be comprehensively supplemented, crop better growth can be regulated, crop yield can be substantially improved, dose is low, and cost is low. The fertilizer has good popularization value. According to the organic water-soluble fertilizer, n-butanol and fatty alcohol polyoxyethylene ether are added as leaf penetration wetting agents, such that foliar absorption of nutrients can be improved, and fertility higher-efficiency utilization can be facilitated. A main component of the fertilizer is modified natural high-molecular polysaccharide with relatively high repelling and inhibiting effects against crop pests and diseases. The component can be used for replacing chemical insecticide or fungistat with toxic or side effect in traditional organic water-soluble fertilizers. The novel organic water-soluble fertilizer is safe and environment-friendly. The fertilizer can naturally degrade in the nature, and has the advantage of low dose. Compared to that of traditional organic water-soluble fertilizers, the cost of the organic water-soluble fertilizer provided by the invention is reduced by approximately 10%. The organic water-soluble fertilizer has the three advantages of high efficiency, environment friendliness, and low cost.
Owner:武汉禾之壮农业科技有限公司

Method and device for determining rock softening curve in bonding crack model

The invention provides a method and a device for determining a rock softening curve in a bonding crack model, which can completely and accurately reflect the three-section change of the rock softeningcurve, can be simultaneously suitable for soft rock and hard rock, and are high in fitting precision and free of human factor interference in the whole process. The rock softening curve determinationmethod comprises the following steps: step 1, acquiring peak stress, peak strain, residual stress and residual strain of a rock to be measured; 2, dividing rock uniaxial tensile test data into soft rock and hard rock according to different rock brittleness indexes B; 3, normalizing the post-peak stage of the rock stress-strain curve; 4, fitting the normalized data by adopting a power-exponentialsoftening function, and determining fitting parameters suitable for soft rock and hard rock respectively; 5, substituting the fitting parameters into the power-index softening function to obtain a rock softening curve in the bond crack model;
Owner:WUHAN UNIV

Resistance large-scale accurate identification method for resisting brown plant-hopper in rice adult-plant stage

ActiveCN108811869ASpeed up progressEfficient resistance identification technologyHorticulture methodsAnimal husbandryBrown planthopperInsect
The invention discloses a resistance large-scale accurate identification method for resisting brown plant-hopper in a rice adult-plant stage, and belongs to the field of rice genetic and breeding. Theresistance large-scale accurate identification method for resisting the brown plant-hopper in the rice adult-plant stage comprises the following steps of (1) rice stubble sample preparation; (2) ricestubble sample planting; (3) excess insect inoculation identification; (4) management after insect inoculation; and (5) identification result assessment. According to the resistance large-scale accurate identification method for resisting the brown plant-hopper in the rice adult-plant stage, a 'rice stubble identification method' is established, and an efficient resistance identification technology is provided for breeding of rice resistance to the brown plant-hopper of various scales. In general, resistance breeding materials of large, medium and small sizes can be identified at a time and can also be identified repeatedly, a seedling period identification result in the adult-plant stage can be identified repeatedly, and the identification result is accurate, thereby effectively promoting the progress of a resistance genetic and breeding project.
Owner:GUANGXI UNIV
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