The invention provides a multiple-target operation optimizing and coordinating control method and a device of a garbage power generator. The multiple-target operation optimizing and coordinating control method includes the following steps. Operational parameters are downloaded from a data communication system (DCS), data judged as reasonable based on a threshold value are transmitted to a database. In terms of environmental protection, economy and safety of the power generator, three models are respectively set up by means of a support vector machine and a fuzzy neural network. A modified strength PARETO genetic algorithm is used for comprehensively optimizing multiple targets and then optimum operation parameters under the present working condition are worked out. Operational staff can adjust operation of corresponding parts based on the optimum operation parameters. The device comprises a data collecting module, a data filtering module, a database module, a data modeling module, an optimizing module, a forecasting module, a remote monitoring module, a monitor, an alarming module and a manual alarming module. The multiple-target operation optimizing and coordinating control method and the device of the garbage power generator achieve multiple functions of real-time forecasting, offline simulation, dynamic optimizing and the like and have the advantages of being strong in adaptability, good in self-learning ability, high in fitting precision, obvious in optimizing effect and the like.