Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
33 results about "Graft failure" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Use of glutaminyl cyclase inhibitors
ActiveUS20090068699A1BiocideOrganic active ingredientsMild cognitive impairment (MCI)Percent Diameter Stenosis
An inhibitor of a glutaminyl peptide cyclotransferase, and use thereof for the treatment and / or prevention of a disease or disorder selected from the group consisting of inflammatory diseases selected froma. neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, Familial Danish Dementia, multiple sclerosis,b. chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis,c. fibrosis, e.g. lung fibrosis, liver fibrosis, renal fibrosis,d. cancer, e.g. cancer / hemangioendothelioma proliferation, gastric carcinomas,e. metabolic diseases, e.g. hypertension,f. and other inflammatory diseases, e.g. neuropathic pain, graft rejection / graft failure / graft vasculopathy, HIV infections / AIDS, gestosis, tuberous sclerosis.Additionally disclosed are a respective diagnostic method, assay and kit.
Owner:VIVORYON THERAPEUTICS NV
Methods and Compositions for Vein Harvest and Autografting
The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS +1
Marker for graft failure and mortality
ActiveUS8889366B2Lower levelAnalysis using chemical indicatorsPeptide/protein ingredientsOrgan transplantationMortality rate
Subject of the present invention is a biomarker for graft failure and / or mortality after organ transplantation. Procalcitonin was found to be a useful marker for the prediction or risk stratification for graft failure and / or mortality of a subject who has received an organ transplant and monitoring and therapy guidance of such subject.
Owner:BRAHMS GMBH
Vascular therapeutics
InactiveUS20050222065A1Organic active ingredientsSenses disorderPercent Diameter StenosisAngiogenesis growth factor
The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and / or solid tumour growth in a subject. The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.
Owner:UNISEARCH LTD
Methods and compositions for the treatment of graft failure
InactiveUS20050261283A1Reduce inhibitionReduce productionBiocideOrganic chemistryPlateletTunica intima
The present invention provides methods and compositions for treating graft failure resulting from neointimal hyperplasia. These methods and compositions feature the use of platelet derived growth factor receptor (PDGFR) inhibitor compounds, such as N-phenyl-2-pyrimidine compounds (e.g., imatinib mesylate) to inhibit the biological activity of the PDGFR.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC
Marker for graft failure and mortality
ActiveUS20110171750A1Lower levelDisease diagnosisBiological testingOrgan transplantationMortality rate
Subject of the present invention is a biomarker for graft failure and / or mortality after organ transplantation. Procalcitonin was found to be a useful marker for the prediction or risk stratification for graft failure and / or mortality of a subject who has received an organ transplant and monitoring and therapy guidance of such subject.
Owner:BRAHMS GMBH
Vascular therapeutics
InactiveUS20050119213A1Lower Level RequirementsOrganic active ingredientsSenses disorderPercent Diameter StenosisAngiogenesis growth factor
The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and / or solid tumour growth in a subject The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.
Owner:NEWSOUTH INNOVATIONS PTY LTD
Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and / or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection / graft failure / graft vasculopathy, HIV infections / AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
Owner:VIVORYON THERAPEUTICS NV
Medical implant for improving cell osteogenesis performance and preparation method thereof
InactiveCN111632195AEasy to rebuildEnhance osteogenic activityBone implantPharmaceutical delivery mechanismLaser processingHuman cell
The invention discloses a medical implant for improving cell osteogenesis performance and a preparation method thereof. The polished and cleaned medical metal is subjected to laser processing so as toobtain a surface structure with super-hydrophilic performance, and a statin drug coating is prepared on the super-hydrophilic surface, so that the drug loading is more uniform and sufficient. The medical implant with the drug coating has the function of enhancing the osteogenesis performance of human cells, is beneficial to rapid and tight combination with human tissues after being implanted intoa human body, is beneficial to smooth implementation of a transplantation operation, and effectively avoids secondary injury caused by transplantation failure.
Owner:BEIHANG UNIV
Methods And Compositions For The Treatment Of Graft Failure
InactiveUS20090041778A1Inhibit biological activityBiocideImmunoglobulins against growth factorsPlateletTunica intima
The present invention provides methods and compositions for treating graft failure resulting from neointimal hyperplasia. These methods and compositions feature the use of platelet derived growth factor receptor (PDGFR) inhibitor compounds, such as N-phenyl-2-pyrimidine compounds (e.g., imatinib mesylate), or mTOR inhibitors (e.g., rapamycin).
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC
Hemodynamic and Morphological predictors of Vascular Graft Failure
A non-invasive method to predict post-surgery vascular graft failure is provided. Computer Tomography Angiography (CTA) images are obtained of a patient post-surgery. A personalized three-dimensional computer model of the patient is derived from the obtained CTA images. The personalized three-dimensional computer model distinguishes a Computational Fluid Dynamics (CFD) model coupled with a closed-loop Lumped Parameter Network (LPN). Post-surgery vascular graft predictors are calculated from the personalized three-dimensional computer model indicative, i.e. predictors, of the post-surgery vascular graft failure or vascular stenosis.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
Grafting method of vine plants
The invention relates to grafting methods, in particular to a grafting method for vine plants. The grafting method comprise the steps that 1, a connecting hose which makes wood penetrate through one end of a ball extends into a ball body; 2, the connecting hose which makes a scion penetrate through the other end of the ball extends into the ball body; 3, docking and positioning of the wood and scion are completed; 4, agar is applied to the connecting place of the wood and the ball body, then the connecting hose is wrapped outside, agar is applied to the connecting place of the scion and the ball body, and the connecting hose is wrapped outside; 5, nutrient solution and growth hormone are injected into the ball body; 6, air or air mixture lighter than the air is injected into the ball body, and then a sealed ball is inflated to seal the ball body. The method for improving the success rate of grafting vine plants is provided in order to solve the problem of grafting failure caused by the soft texture of vine plants.
Owner:遵义强大博信知识产权服务有限公司
Porous Ti-based nano-composite material for hard tissue material and preparation method and application thereof
ActiveCN108404222AGood dispersionImprove bindingSurface reaction electrolytic coatingTissue regenerationDispersityRelease time
The invention provides a porous Ti-based nano-composite material. The porous Ti-based nano-composite material comprises a porous Ti-based material, a hydroxyapatite layer composited on the porous Ti-based material, and chitosan-vancomycin composited on the hydroxyapatite layer. The porous Ti-based nano-composite material is capable of, through the porous Ti-based material, reducing or eliminatinga 'stress shielding' effect, and has a stronger binding force. The provided porous Ti-based nano-composite material is further provided with the chitosan-vancomycin composited on the outer surface, the porous Ti-based nano-composite material and the chitosan-vancomycin are combined for greatly solving problems that infection is easy suffered after an osteogenesis transplantation operation at the present stage, inflammation or function degeneration of a transplant are caused so that the transplantation is failure, a binding force problem is existent and drug controlled-release time is short. The provided porous Ti-based nano-composite material is capable of using a porous structure to combine a HAp, a chitosan-functionality drug, and a combined composite coating better, and better in dispersity, and stronger in binding force. The controlled-release time is apparently improved, and the long-term anti-bacterial effect is achieved.
Owner:湖南早晨纳米机器人有限公司
Bypass vascular graft
A vascular bypass graft having a primary member and a secondary member is disclosed. The secondary member extends from a distal second end of the primary member and has a common fluid pathway there between. The secondary member may have a flared or diffused proximal first end that facilitates low pressure fluid return and may be integrally formed with the primary member. An adjustable or fixed stenosis is provided in the secondary member which allows the fluid flow through the vascular bypass graft to be modified. The stenosis may be adjusted either manually or by way of a controller. The primary member is surgically connected to a patient's vascular system to provide an alternate route for blood flow around a vascular occlusion. The secondary member is surgically connected to another point in the vascular system to allow continuous circulation of blood through the graft thereby preventing clotting and graft failure.
Owner:BATISTE STANLEY
Multi-species top grafting method for pumpkins
ActiveCN109769489ASolve the high failure rate of graftingSolve the resultGraftingGrowth substratesWound healingFailure rate
The invention discloses a multi-species top grafting method for pumpkins, and relates to the field of pumpkin grafting. The method specifically comprises the following steps of step 1, species selection, wherein a rootstock pumpkin and a scion pumpkin are selected; step 2, preparation before seeding; step 3, seeding; step 4, grafting, wherein when 12-15 main pumpkin leaves grow, topping is performed, and a sufficient amount of fertilizers and water are applied, when the third main leaf of a branch is expands, grafting is performed by adopting a cleft grafting method, hydrogen-rich water with amass fraction of 270-320 ppm is sprayed 4-5 times a day, and grafting plastic or grafting clips are removed after survival; step 5, maintenance in a viewing period. The multi-species top grafting method for the pumpkins has the advantages that the design is reasonable, by using the hydrogen-rich water for grafting of ornamental pumpkins with the assistance of the steps such as the species selection and seeding, the problems of high multi-species grafting failure rate, difficult fruiting, difficult wound healing and weaker growth of the ornamental pumpkins can be solved, the pumpkins with great ornamental value can be obtained, and the application prospect is broad.
Owner:佛山市农业科学研究所
Management method for grafted walnut tree
ActiveCN106613690AReduce top edgeStrong growthCultivating equipmentsHorticulture methodsFruit treeAxillary bud
The invention relates to a management method for a grafted walnut tree and belongs to the field of fruit tree grafting management. The method includes the steps that within 25d-35 d after the walnut tree is grafted and survives, a plastic film on a grafting wound is removed, and the grafting wound is bound with newspaper; after grafting is completed, when a shoot of a scion grows to 20-50 cm, a top end growth part of the shoot is cut out, after an axillary bud of the shoot germinates to form a secondary shoot, the axillary bud is cut out from a stem base, the apical dominance of the scion shoot can be reduced to a certain degree, a newborn branch of the scion grows more vigorously, branches scrambling for nutrients are reduced, the grafted tree vigor restores robustness as soon as possible, the grafting wound rapidly heals, the secondary repairing and linking labor and material expense cost generated by grafting failure is reduced, the phenomenon that a current-year shoot is easily swabbed off when encountering extreme low temperature in winter is avoided, the scion is prevented from being snapped by strong wind, and the preservation rate and the next-year yield of the grafted walnut tree are increased.
Owner:新疆林科院经济林研究所
Nucleus covered with PHA
InactiveCN103491769AImprove qualityReduce graft failureClimate change adaptationPisciculture and aquariaBioactive moleculesZosteric acid
Owner:法国海洋勘探研究所 +1
Genetic engineering of vascular grafts to resist disease
InactiveUS7282488B2Restoring the capacity to generate activated protein CImprove graft patencyOrganic active ingredientsVirusesDiseaseProtein activation
Disclosed are methods for treating a vascular graft that include introducing an effective amount of at least one nucleic acid encoding at least one agent that increases activated protein C (APC), expressing the agent in the cells; and increasing the APC sufficient to treat the blood vessel. Also provided are vascular grafts engineered to resist early and / or late graft failure.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Ultra-high sensitive monitoring of early transplantation failure
ActiveUS20150126373A1Low costFailure in transplantationMicrobiological testing/measurementLibrary screeningOrgan transplantationBlood plasma
The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.
Owner:CITY OF HOPE
Traditional Chinese medicine composition for treating low blocking antibodies
InactiveCN110279827AStrengthen the function of nourishing the middle and replenishing QiSound opening and closing functionSexual disorderPlant ingredientsCure rateInevitable abortion
The invention provides a medicine for treating low blocking antibodies. The traditional Chinese medicine composition is prepared from 15-30 parts of radix astragali, 9-15 parts of rhizoma atractylodis macrocephalae, 6-9 parts of dried orange peel, 12-24 parts of radix ginseng, 6-9 parts of radix bupleuri, 6 parts of rhizoma cimicifugae, 6 parts of radix glycyrrhizae, 10-12 parts of radix angelicae sinensis, 12-15 parts of parched white peony roots, 12-15 parts of radix rehmanniae preparata, 3-6 parts of fructus amomi and 9-12 parts of rhizoma chuanxiong. All the medicines are combined for use and can provide sufficient healthy qi and full qi and blood to obtain yang blocking antibodies. The traditional Chinese medicine composition is simple to use, convenient, safe, harmless to the human body, high in cure rate, short in treatment course and low in treatment cost. The traditional Chinese medicine composition has the benefits that the traditional Chinese medicine composition is used for patients with low blocking antibodies due to inevitable abortion, recurrent spontaneous abortion, transplantation failure history or repeated transplantation failure.
Owner:周菲菲
Methods and compositions for vein harvest and autografting
The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS +1
Chinese medicine composition for treating leukemia bone marrow transplant failure complicated by brain stem stroke after chemotherapy
ActiveUS10300098B2Relieve and cure leukemiaImprove hemiplegiaPlant ingredientsChinese cinnamonBrain stem stroke
Owner:LEE CHEN YU
Nucleus covered with pha
InactiveUS20130263793A1Quality improvementFireproof paintsLiquid surface applicatorsBioactive moleculesZosteric acid
The present invention relates to a nucleus covered or coated with a film including one or more PHA. The invention also relates to a PHA, characterized in that it is of the type PHB-V, a film and a composition including the PHA. The invention further relates to a film or a composition including a PHA and zosteric acid or a bioactive molecule. The invention moreover relates to a surface, preferably a nucleus, covered with the film of PHA, a method for production thereof, and methods for grafting a pearl oyster and producing a pearl using this nucleus. Finally, the present invention relates to a method for reducing graft failure and / or for improving the quality of the pearl using the nucleus according to the invention.
Owner:IFREMER INST FR DE RECH POUR LEXPL DE LA MER +1
Hemodynamic and morphological predictors of vascular graft failure
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
Use of chymase inhibitors for the prevention and/or treatment of arterio-venous graft failure
InactiveCN1708305ASuppress generationInhibition releaseOrganic active ingredientsImmunological disordersVenous graftMedicine
The present invention discloses a method for treating AV graft failure in a patient in need thereof, said method comprising administering to said patient an effective dose of a formulation capable of inhibiting chymotrypsin To generate, release, or inhibit the formation of neointima, the effective dose of the preparation is the dose that can effectively treat the failure of the AV graft.
Owner:SOC DE CONSEILS DE RECH & DAPPLICATIONS SCI SAS
Aeroponic culture breeding method for grafting tomatoes on potatoes and potato and tomato seedlings bred by aeroponic culture breeding method
InactiveCN112690200AImprove survival rateImprove absorption and utilizationAgriculture gas emission reductionCultivating equipmentsEconomic benefitsPest control
The invention provides an aeroponic culture breeding method for grafting tomatoes on potatoes and potato and tomato seedlings bred by the aeroponic culture breeding method, and particularly relates to the technical field of soilless culture. According to the aeroponic culture breeding method for grafting the tomatoes on the potatoes, the problems of grafting failure and low survival rate after grafting due to incoordination of a reservoir source relationship of the potatoes and the tomatoes can be effectively solved, the potato and tomato seedlings with the tomatoes growing on the upper portion and the potatoes (potato breeder's seeds) growing on the lower portion can be cultivated through the method, and the survival rate is high. Moreover, the potato and tomato seedlings are cultivated by adopting the aeroponic cultivation method, and soilless and matrix-free cultivation is realized, so that the absorption and utilization rate of the seedlings on a nutrient solution is high, and the economic benefit is relatively high. In addition, the potato and tomato seedlings bred through the method are high in disease resistance and good in pest control effect. The miniature potatoes and the tomatoes produced by the potato and tomato seedlings are good in quality, the tomatoes are good in taste and flavor, and economic benefits are high.
Owner:周爱爱 +1
A porous titanium-based nanocomposite material for hard tissue materials and its preparation method and application
ActiveCN108404222BGood dispersionImprove bindingSurface reaction electrolytic coatingTissue regenerationTitanium matrix compositesDrug release
Owner:湖南早晨纳米机器人有限公司
Methods for assessing graft failure risk
PendingUS20200170580A1Reduce riskIncreasing immunosuppressive regimenMedical simulationMechanical/radiation/invasive therapiesSerum creatineAntiendomysial antibodies
The present invention relates to methods for assessing graft failure risk. Many predictive models of graft survival based on large panels of data collected exist but a limitation of these models is that they do not take into account the onset of adverse events over time, which modify graft outcome. The inventors developed a conditional and adjustable score, taking into account onset of emerging risks over time such as development of dnDSA, for prediction of graft failure (AdGFS) up to 10 years post-transplantation in 664 kidney transplant patients. AdGFS was externally validated and calibrated in 896 kidney transplant patients. In particular, the present invention relates to a method of assessing graft failure risk in a subject by measuring several factors: serum creatinine concentration, de novo donor-specific anti-HLA antibodies, pretransplant non donor-specific anti-HLA antibodies, acute rejection, age, proteinuria longitudinal serum creatinine cluster.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
Management method used after peach tree grafting
The invention discloses a management method used after peach tree grafting. The management method used after peach tree grafting includes the steps of film uncovering, piled soil inspection, rootstockbud stripping, fertilization, drainage and irrigation, and prevention of diseases, pests and weeds. Compared with the prior art, the method reduces branches competing for nutrients, tree vigor aftergrafting restores robustness, grafting wounds quickly heal, the manpower and material cost for secondary grafting caused by grafting failures is reduced, the phenomenon that annual shoots are likely to be dry at extreme low temperature in winter is avoided, scions are prevented from being broken by strong winds, and the preservation rate and next-year yield of peach trees after grafting are improved.
Owner:泰州海乐鲜餐饮管理有限公司
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com