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Porous Ti-based nano-composite material for hard tissue material and preparation method and application thereof

A composite material and porous titanium technology, applied in the direction of tissue regeneration, electrolytic coating, surface reaction electrolytic coating, etc., can solve the problems of unsatisfactory biological activity, inability to reduce adverse effects, poor comprehensive mechanical properties, etc., and achieve strong binding force , Good dispersibility, combined compact effect

Active Publication Date: 2018-08-17
湖南早晨纳米机器人有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the patent CN103014801A discloses a preparation method of electrodeposition for titanium-based hydroxyapatite biomedical composite materials. The pretreated titanium or titanium alloy substrate is prepared on the surface of the titanium base by constant current or constant voltage electrodeposition. A layer of hydroxyapatite coating can improve the affinity and biocompatibility with the body, promote the growth of new bone, the preparation process is simple, and the reaction avoids high temperature, but there are still poor comprehensive mechanical properties. The performance is considerable, but the biological activity is not ideal, etc., the elastic modulus is large, the rigidity is high, and the adverse effects of the "stress shielding" effect cannot be reduced

Method used

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  • Porous Ti-based nano-composite material for hard tissue material and preparation method and application thereof
  • Porous Ti-based nano-composite material for hard tissue material and preparation method and application thereof
  • Porous Ti-based nano-composite material for hard tissue material and preparation method and application thereof

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preparation example Construction

[0082] The present invention also provides a method for preparing a porous titanium-based composite material, comprising the following steps:

[0083] 1) After the pretreated titanium-based material is subjected to an anodic oxidation process and annealing treatment, a titanium-based material with a porous structure surface is obtained;

[0084] After mixing chitosan and vancomycin mixed solution, calcium salt, phosphorus salt and water, adjust the pH value to obtain the first mixed solution;

[0085] 2) Electrodepositing the titanium-based material with a porous structure surface and the first mixed solution obtained in the above steps to obtain a semi-finished product;

[0086] 3) The semi-finished product obtained in the above steps is soaked in alkali to obtain a porous titanium-based composite material.

[0087] The selection, proportion and corresponding optimization principles of the raw materials in the preparation method in the present invention are consistent with t...

Embodiment 1

[0134] The titanium alloy with a size of 40×20×1mm was polished with sandpaper in sequence, and then ultrasonically cleaned in acetone, absolute ethanol and deionized water for 10 minutes respectively. Electrochemical polishing is carried out in the polishing solution of phosphoric acid: sulfuric acid: water = 1:3:10 (volume ratio), and the electrochemical polishing is carried out in an oil bath device at 85°C, the stirring speed is 800r / min, and the constant current method is used for polishing. The density is 25A / dm 2 , the polishing time is 10s, and the polished sample is ultrasonically cleaned with deionized water for 10 minutes. After completion, it is taken out, rinsed, and dried with cold air. area and prevent edge polarization.

[0135] The anodic oxidation adopts the constant voltage method, the hydrofluoric acid solution is used as the electrolyte, the hydrofluoric acid concentration is 0.5wt%, the oxidation voltage is 10V, the oxidation time is 1h, the oxidation te...

Embodiment 2

[0149] The titanium alloy with a size of 40×20×1mm was polished with sandpaper in sequence, and then ultrasonically cleaned in acetone, absolute ethanol and deionized water for 15 minutes respectively. Electrochemical polishing is carried out in the polishing solution of phosphoric acid: sulfuric acid: water = 1:3:10 (volume ratio), and the electrochemical polishing is carried out in an oil bath device at 87°C, the stirring speed is 1000r / min, and the constant current method is used for polishing. The density is 35A / dm 2 , the polishing time is 15s, and the polished sample is ultrasonically cleaned with deionized water for 13 minutes. After the completion, take it out, rinse it, and dry it with cold air. area and prevent edge polarization.

[0150] Anodic oxidation adopts constant voltage method, hydrofluoric acid solution is used as electrolyte, the concentration of hydrofluoric acid is 0.5wt%, oxidation voltage is 20V, oxidation time is 1h, oxidation temperature is 25°C, st...

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Abstract

The invention provides a porous Ti-based nano-composite material. The porous Ti-based nano-composite material comprises a porous Ti-based material, a hydroxyapatite layer composited on the porous Ti-based material, and chitosan-vancomycin composited on the hydroxyapatite layer. The porous Ti-based nano-composite material is capable of, through the porous Ti-based material, reducing or eliminatinga 'stress shielding' effect, and has a stronger binding force. The provided porous Ti-based nano-composite material is further provided with the chitosan-vancomycin composited on the outer surface, the porous Ti-based nano-composite material and the chitosan-vancomycin are combined for greatly solving problems that infection is easy suffered after an osteogenesis transplantation operation at the present stage, inflammation or function degeneration of a transplant are caused so that the transplantation is failure, a binding force problem is existent and drug controlled-release time is short. The provided porous Ti-based nano-composite material is capable of using a porous structure to combine a HAp, a chitosan-functionality drug, and a combined composite coating better, and better in dispersity, and stronger in binding force. The controlled-release time is apparently improved, and the long-term anti-bacterial effect is achieved.

Description

technical field [0001] The present invention relates to the technical field of biomedical materials, and relates to a porous titanium-based composite material and its preparation method and application, in particular to a porous titanium-based nanocomposite material for hard tissue materials and its preparation method, in terms of biomedical materials Applications. Background technique [0002] With the acceleration of population aging and the sharp increase of various accidental injuries, the number of patients with hard tissue defects is increasing. According to the forecast of the United Nations Organization for Economic Cooperation and Development, by 2020, the resulting hard tissue repair products will The market cap will reach $800 billion. [0003] As an important part of biomedical materials, hard tissue materials play an important role in repairing defective human hard tissues (bones, joints, etc.) and reconstructing lost physiological functions. Bone defect repai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/42A61L27/46A61L27/48A61L27/54A61L27/32A61L27/34C25D11/26C25D15/00
CPCA61L27/06A61L27/12A61L27/20A61L27/32A61L27/34A61L27/54A61L27/56A61L2300/404A61L2300/406A61L2430/02C25D11/26C25D15/00C08L5/08
Inventor 皮立波孙若为温景成孙一绮杨志
Owner 湖南早晨纳米机器人有限公司
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