151 results about "ACUTE INFLAMMATIONS" patented technology

The invention discloses a double detection line SAA (Serum amyloid A protein) immunofluorescence chromatography quantitative detection reagent and a preparation method thereof. The double detection line SAA immunofluorescence chromatography quantitative detection reagent can simultaneously promote sensitivity and detection scope and can be applied to clinical detection for SAA level in patients of acute inflammation and chronic inflammation. According to the technical key points, the reagent comprises a base plate, a combining cushion, a coating film and an absorbing cushion, wherein a sample cushion is connected with the base plate; anti-SAA monoclonal antibody 1 and chick IgY are sprayed on the combining cushion and are marked with a same fluorescent microsphere; a detection line T1, a detection line T2 and a quality control C line are arranged on the coating film; anti-SAA monoclonal antibody 2 is coated with the detection line T1; antigen SAA protein is coated with the detection line T2; goat-anti-chick IgY is coated with the quality control C line. The reagent belongs to the technical field of in-vitro diagnostic reagents.

An object of the present invention is to provide a compound having a novel structure for overcoming the defects of conventional steroid agents and NSAIDs. It is found that the particular dihydroxy bodies of eicosapentaenoic acid and docosahexaenoic acid, which have not conventionally been known (11,18-dihydroxy eicosapentaenoic acid (11,18-diHEPE), 17,18-dihydroxy eicosapentaenoic acid (17,18-diHEPE) etc.), have activity of inhibiting neutrophil, thereby solving the object. The present invention unexpectedly remarkably inhibits infiltration into a tissue of, and activation of neutrophil found out at acute inflammation. The compound of the present invention is a compound which has not conventionally been known. Therefore, utility as a new therapeutic is provided.

Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells.

Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells.

The invention discloses a panda source lactobacillus plantarum and application. The strain was preserved in China Center for Type Culture Collection on May 4, 2016 and the preservation number is CCTCC NO: M2016245. The panda source lactobacillus plantarum provided by the invention can be used for improving antibody levels of IgA, IgM and IgG immune globulins of blood serum; a condition that the percent of lymphocytes is reduced and the percent of neutrophils is increased, caused by infection and induction of enterotoxigenic escherichia coli, is inhibited; expression levels of inflammation related factors IL-1beta, IL-8, IL-6, TLR4 and MyD88mRNA (messenger Ribonucleic Acid) are remarkably down-regulated, and intestinal acute inflammation response caused by the enterotoxigenic escherichia coli is alleviated.

A compound for the manufacturing of a medicament for reducing or preventing mesothelial cell damage includes a mixture of a carrier gas and between 1 volume percent and 29 volume percent of nitrous oxide gas (N2O) and can be used for prevention of adhesion formation, pain reduction, reducing or preventing acute inflammation, reducing or preventing CO2 resorbtion or reducing tumor cell implantation upon surgery.

The invention belongs to the fields of natural medicines and cosmetics, and discloses applications of Chinese torreya essential oil in preparing medicines for treating inflammation-related diseases, and applications of Chinese torreya essential oil as the functional component in the cosmetics, so that the anaphylactic reaction of the cosmetics is reduced, and the anti-inflammatory repairing capacity of the skin is improved. The animal inflammation experiment proves that no matter after Chinese torreya essential oil is taken orally or externally applied, the mouse acute inflammation caused by egg white can be obviously inhibited, and in addition, the mouse acute inflammation caused by carrageenin also can be obviously inhibited. Chinese torreya essential oil is prepared from Chinese torreya aril through a distillation method, a cold pressing method, a solvent extraction method or a CO2 supercritical extraction method. The requirements for the quality of the Chinese torreya essential oil are as follows: the colourless or chartreuse liquid adopted has the characteristic aroma of Chinese torreya fruits, and has the relative density (at 20 DEG C / 20 DEG C) being 0.850-0.860, and the sum of the contents of the characteristic components alpha-pinene and limonene is greater than or equal to 30%. The invention discloses the novel applications of Chinese torreya essential oil in preparing the anti-inflammatory medicines or cosmetics. In addition, by comparing the advantages and disadvantages of different extraction methods of Chinese torreya essential oil, the invention provides a preferable preparation method of Chinese torreya essential oil.

The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

The present invention belongs to the field of medicine technology and discloses an effective dose containing acetylcysteine or pharmaceutically acceptable salts thereof, and at least one pharmaceutical composition of anti-infective drugs as well as usage and method for making same, wherein the antiinfective drugs are one or several compounds selected from new houttuynine sodium bisulfite or pharmaceutically acceptable salt thereof and / or 14-dehydroxyl-11, 12-dehydro andrographolide-3, 19-di-succinic acid half-ester salts and / or matrine. Said pharmaceutical composition can be made into pharmaceutically acceptable dosage forms and exhibits cooperative building action when being used for diseases such as pneumonia, bronchial asthma, haggis acute inflammation accompanying with chronic emphraxis haggis diseases caused by sensitive bacteria; in addition, possesses excellent stability, exhibits considerably improved effects relative to used individually medicament of the same dose, and results in effects beyond thoughts, possesses wide-ranging applications foreground.

The invention provides the application of carubinose in preparing medicine that can treat lung acute inflammation diseases. The molecular formula of carubinose is C6H12O6, the structure is D-carubinose. Said medicine comprises medicine acceptable shaping agent or carrying agent. The produced dosage form mainly comprises liquid dosage form, granule, tablet, gas spraying form, drop or pill. The invention can reduce the lung tissue TNF-alpha level of mice ALT model induced by LPS, release neutral granulocyte wettability in lung tissue, inhibit capillary blood permeability, decrease protein exudation and lung water content, reduce MPO level in BALF supernatant and improve pathologic change for lung tissue inflammation. The invention discloses the functions of anti-inflammation, anti-oxidation and pneumochysis reduction of carubinose.

The invention relates to an anti-inflammatory effective part of a leaf of Santalum album L.. The anti-inflammatory effective part comprises vitexin, isovitexin and orientin, and the content of the vitexin, the isovitexin and the orientin in the effective part is not less than 80%. The invention further provides a preparation method and application of the anti-inflammatory effective part of the leaf of Santalum album L.. The anti-inflammatory effective part of the leaf of Santalum album L. is clear in chemical components and the content of the known components exceeds 80%; systematic anti-inflammatory experiments show that the effective part is effective in treatment of acute inflammation.

The invention relates to a preparation method of traditional Chinese medicine for treatment of yang deficiency, qi stagnation and blood stasis type chronic pelvic inflammatory disease, belonging to the technical field of a preparation method of traditional Chinese medicine. At present, the chronic pelvic inflammatory disease only includes tuberculous pelvic inflammatory disease and pelvic actinomycosis, and the pelvic inflammatory disease caused by other pathogens do not exist actually and are sequelaes of acute inflammation with no pathogen infection in tissues, which cannot be treated generally by western antibiotic treatment in the clinical practice. In the technical scheme, 12g of antler, 5g of baked ginger, 3g of fennel, 10g of cassia twigs, 10g of eucommia ulmoides, 10g of radix rehmanniae, 10g of codonopsis pilosula, 9g of angelica sinensis, 5g of pollen typhae, 9g of trogopterus dung, 9g of corydalis tuber, 9g of rhizoma sparganii, 9g of curcuma zedoary, 9g of radix linderae, 10g of radix astragali preparata, 6g of licorice are added into 1000ml of water, soaked for 30 minutes and then decocted by mild fire, the decocted medical solution is filtered by gauze, bottled and then sealed, and thus the traditional Chinese medicine for treatment of the yang deficiency, qi stagnation and blood stasis type chronic pelvic inflammatory disease is prepared. The invention has the advantages that the traditional Chinese medicine has smaller toxic and side effects, and the efficacy is long-lasting, stable and satisfactory after the medicine is taken.