Medical skin marker
A skin and pen tip technology, applied in the field of medical supplies, can solve the problems of fading, loss, poor color fixation of the mark, etc., and achieve the effects of good antibacterial properties, reduced possibility and good stability
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[0051] The synthetic method of commonly used 4-tert-butyl cyclohexanol comprises: (1) carry out tert-butylation reaction with phenol and isobutene in the presence of aluminum trichloride, then use Raech's nickel W7 catalytic hydrogenation to obtain cis- and trans - the compound of 4-tert-butyl cyclohexanol, wherein the trans structure accounts for more than 70%; (2) carry out tert-butylation reaction with phenol and isobutylene in the presence of aluminum trichloride, and then catalytic hydrogenation can obtain cis- and Mixture of trans-4-tert-butylcyclohexanol. Generally purchased 4-tert-butylcyclohexanol products are a mixture of cis and trans.
[0052] cis-4-tert-butylcyclohexanol is white needle or powder crystal. It is a known fragrance ingredient with an exceptionally dry, woody camphor-like odor and a leathery aftertaste, and is used in artificial patchouli oils and soap fragrances to provide intensity, diffusion, and radiance . However, there are some reports of a m...
Embodiment 1
[0096] Embodiment 1 provides a kind of medical skin pen, comprise pen body by pen cap, nib and pen holder, inner core is arranged in pen body, one end of pen core is inserted into inner core, is filled with gentian violet ink in the described inner core; The gentian violet ink described in parts by weight at least includes the following components: 1 part by weight of gentian violet, 0.1 part by weight of potassium sorbate, 0.1 part by weight of 4-tert-butylcyclohexanol, 5 parts by weight of white oil, L- 0.1 part by weight of arginine, 0.1 part by weight of cyclodextrin, 30 parts by weight of alcohol containing 2 to 6 carbon atoms, and 35 parts by weight of distilled water.
[0097] The cyclodextrin is a trimethylsiloxysilicate modified α-cyclodextrin, and in the trimethylsiloxysilicate modified cyclodextrin, trimethylsiloxysilicon The molar ratio of acid ester and cyclodextrin is 1:1.
[0098] The preparation method of the described trimethylsiloxysilicate modified cyclodex...
Embodiment 2
[0105] Embodiment 2 provides a kind of medical skin pen, comprises a pen body made of a pen cap, a nib and a pen holder, an inner core is arranged in the pen body, one end of the pen core is inserted into the inner core, and the described inner core is filled with gentian violet ink; The gentian violet ink described in parts by weight at least includes the following components: 2 parts by weight of gentian violet, 1 part by weight of potassium sorbate, 2 parts by weight of 4-tert-butylcyclohexanol, 10 parts by weight of white oil, L- 1.5 parts by weight of arginine, 1 part by weight of cyclodextrin, 50 parts by weight of alcohol containing 2 to 6 carbon atoms, and 60 parts by weight of distilled water.
[0106] The cyclodextrin is a trimethylsiloxysilicate modified α-cyclodextrin, and in the trimethylsiloxysilicate modified cyclodextrin, trimethylsiloxysilicon The molar ratio of acid ester and cyclodextrin is 1:2.
[0107] The preparation method of the trimethylsiloxysilicate...
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