89 results about "M-aminoacetophenone" patented technology

A photocurable composition is provided that includes a polymerizable compound, a photopolymerization initiator, a compound represented by Formula (I) below, and an amine compound, the photopolymerization initiator comprising an acylphosphine oxide compound and/or an α-aminoacetophenone compound

in Formula (I) above, X denotes O, S, or NR, n denotes 0 or 1, R denotes a hydrogen atom, an alkyl group, or an acyl group, R¹, R², R³, R⁴, R⁵, R⁶, R⁷, and R⁸ independently denote a hydrogen atom or a monovalent substituent, and two of R¹, R², R³, and R⁴ that are adjacent may be bonded to each other to form a ring. There are also provided a photocurable ink composition that includes the photocurable composition and a colorant, an ink composition for photocuring inkjet recording that includes the photocurable ink composition, a process for producing a photocured material that includes preparing the photocurable composition and irradiating the photocurable composition with light having a light emission peak in the range of at least 340 nm but no greater than 400 nm, and an inkjet recording method that includes discharging the ink composition onto a recording medium and irradiating the ink composition with actinic radiation.

A photocurable and thermosetting resin composition comprising (A) a carboxyl-group containing resin, (B) an oxime ester-based photopolymerization initiator containing an oxime ester group, (C) an aminoacetophenone-based photopolymerization initiator and/or a phosphine oxide-based photopolymerization initiator, (D) a compound having at least two ethylenically unsaturated groups in its molecule, (E) a filler, and (F) a thermosetting component is capable of being developed with a dilute alkaline solution and cured with a laser emission source having a maximum wavelength of 350 nm to 420 nm.

A holographic recording medium has a recording layer including a radical-polymerizable compound, a first photo-radical polymerization initiator (A) containing a titanocene compound, and a second photo-radical polymerization initiator (B) containing at least one compound selected from the group consisting of an amino acetophenone derivative, an acylphosphine oxide derivative, a benzyl derivative, and a thioxanthone derivative.

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

The invention relates to a method for synthesizing indiplon, which comprises the following steps: using low-cost available 3-aminoacetophenone as a starting raw material; reacting the 3-aminoacetophenone with acetic anhydride to convert the 3-aminoacetophenone into 3-acetamido-acetophenone; reacting the obtained 3-acetamido-acetophenone with powdered potassium hydrate first and then with iodomethane to convert the 3-acetamido-acetophenone into N-methyl-N-(3-acetyl-phenyl)-acetamide; reacting the obtained N-methyl-N-(3-acetyl-phenyl)-acetamide with ethyl formate under the action of sodium ethylate to obtain an alkali metal 3-(N-methyl-N-acetyl)amino-beta-ketone-phenyl-propionaldehyde enol salt; and synthesizing the indiplon by condensing the obtained alkali metal 3-(N-methyl-N-acetyl) amino-beta-ketone-phenyl-propionaldehyde enol salt and (3-amino-1H-pyrazole-4-yl)-2-thiophene ketone. The method has the advantages of low cost, mild reaction condition, safety and environmental protection, and easy industrialized production, and the obtained indiplon can be used as hypnagogue for treating anhypnosis.

Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism or for genetic screening to identify pigs on the basis of their skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

The invention discloses an aminoacetophenone thiosemicarbazone derivative shown as a formula I and application thereof. In the formula I, an amino group connected with R is at 3 position or 4 position of the phenyl ring, and R is selected from C1-C6 alky or halogenated alkyl or alkoxy, aryl or substituted aryl. The related compounds are novel in structure and simple to prepare, are strong in inhibition activity on tyrosinase and have extremely obvious application prospect.

A preparation technology of high purity 3-hydroxyacetophenone comprises the following steps of: adding 38 weight portions of 3-nitroacetophenone and 37 weight portions of water into a reaction vessel, adding an iron powder to react for 10 hours, adding methanol with stirring, centrifuging a precipitate for removing water to obtain 3-aminoacephenone, pouring the 3-aminoacephenone into a diazonium kettle; adding sulfuric acid, slowly adding a sodium nitrite aqueous solution into the diazonium kettle to produce 3-diazo sulfate acetophenone, adding 3-diazo sulfate acetophenone into a hydrolysis kettle, and finally drying to obtain the pure product 3-hydroxyacetophenone. The invention has advantages of simple technology, high yield of the product and high purity. By reasonable design of the reaction steps and adjustment of charging order, the application amount of strong acid is greatly reduced; in addition, by the addition of a certain amount of methanol in the reaction, the process of the reaction can be accelerated and the synthesis quality can be raised. According to statistics, the overall yield of the technology can reach over 92%; compared with other production technologies, the technology provided by the invention enables the product cost to decrease by more than 40%, and is environmentally friendly.

The invention relates to an alpha-aminoacetophenone photoinitiator intermediate preparation method, particularly to a preparation method of an intermediate of photoinitiators 2-benzyl-2-dimethylamino-1-(4-morpholinylphenyl)butanone and 2-(4-methylbenzyl)-2-dimethylamino-1-(4-morpholinylphenyl)butanone. According to the present invention, the disadvantages in the prior art are overcome, and the alpha-aminoacetophenone photoinitiator intermediate preparation method is provided, wherein the method does not require high-temperature and high-pressure feeding, has simple post-treatment, has good product appearance, and is suitable for industrial production.

The invention discloses a quinoline derivative efficient catalytic synthesis method belonging to the technical field of organic synthesis. The molar ratio of an active alpha-methyl or methylene carbonyl compound and 2-amino acetophenone is 1: 1, the molar amount of a multi sulfonic acid r adical acidic ionic liquid catalyst is 7-10% of the use amount of the 2-amino acetophenone, the reaction solvent 75% ethanol aqueous solution volume (ml) is 3-5 times of the molar amount (mmol) of the 2-amino acetophenone, the reflux reaction time is 5-25min, a filter residue is obtained by cooling to room temperature after the reaction and filtering, and the obtained filter residue is dried under vacuum to obtain a pure quinoline derivative. Compared with a synthesis method using other acidic ionic liquid as a catalyst, the catalyst has high catalytic activity, less use amount and less loss quantity during the circulation use, and the whole synthetic process has the advantages of being simple, convenient, economic and the like, and is convenient for industrialized mass production.

The invention discloses a titanocene complex with oxygen-containing carboxylic acid as well as a preparation method and an application of the titanocene complex. The structural formula of the complexis shown in the description. The titanocene complex is prepared from oxygen-containing carboxylic acid as a ligand, titanocene dichloride as Lewis acid and 5-sulfosalicylic acid as a transitional ligand. The complex is stable to air, the raw materials used in the synthesis method are low in cost and easy to obtain, synthesis steps are simple and easy, post-treatment of the product is simple, conditions are mild, and the yield of the target product is high. The complex is used for catalyzing reaction of 2-aminoacetophenone and aromatic aldehyde for synthesis of 2-aryl-2,3-dihydroquinolinone, and better yield is obtained.

The invention relates to a stable isotope labeling Clenproperol compound and a synthesis method thereof. The method comprises the following steps of (1) using stable isotope labeling 2,6-dichloroaniline as raw materials to generate stable isotope labeling 3,5-dichloro-4-aminoacetophenone through Friedel-Crafts acyl reaction; (2) performing bromination on the stable isotope labeling 3,5-dichloro-4-aminoacetophenone to obtain stable isotope labeling 3,5-dichloro-4-amino-alpha-bromo acetophenone; (3) enabling the stable isotope labeling 3,5-dichloro-4-amino-alpha-bromo acetophenone and isopropylamine to take a reaction for obtaining stable isotope labeling 1-(4-amino-3,5-dichlone)-2-isopropyl amino ethyl ketone; (4) enabling the stable isotope labeling 1-(4-amino-3,5-dichlone)-2-isopropyl amino ethyl ketone and a reducing agent to take a reaction to generate stable isotope labeling Clenproperol. The stable isotope labeling Clenproperol compound and the synthesis method have the advantages that the process route is simple; the synthesis is easy; the stable isotope atom utilization rate is high; the obtained product can be easily separated and purified; the chemical purity and the fractional isotopic abudance are 99 percent or higher; the trace detection requirements in the food safety field can be sufficiently met.

The invention relates to a synthesis method for 2,3'-dichloroacetophenone (alpha-chloro-acetophenone inter-chlorophenyl) and is characterized in that the method takes inter-amino-acetophenone as raw material to generate between inter-acetophenone diazo-hydrochloride through diazotization reaction, or generate inter-p-acetophenone through Sandmeyer reaction, or generate 2,3'-dichloroacetophenone through alpha-chloro-reaction; the synthetic way is simple and the conditions are mild, with a total yield rate more than 80%.

The invention provides a preparation method for special syrup for a rainbow candy. The preparation method comprises the following steps: mixing a corn starch and water to form a corn slurry, adding astarch milk B, and preparing the special syrup for the rainbow candy through the processes of liquifying, saccharifying, mixing, filtering, decolorizing, hybridizing, adsorbing through polymerizing foreign compounds with special resin, and evaporating. The glucose content in the produced special syrup for the rainbow candy is 42.0-46.0%, the maltose content is 25.0-32.0%, the DE value is 63-70%, and the chromaticity is less than or equal to 10. Through the polymerized adsorption, the hydroxymethyl furfural of a product is controlled to be lower than or equal to 75 ppm, the furfural is controlled to be lower than or equal to 2.0 ppm, the acetaldehyde is controlled to be lower than or equal to 80 ppb, the diaminoacetophenone (2AP) is controlled to be lower than or equal to 0.5 ppb, the isovaleraldehyde is controlled to be lower than or equal to 5.0 ppb, the influence of an odorous compound on the sensory threshold is reduced, and the adverse effect on the flavor of the product is avoided, so that the taste and the flavor of the rainbow candy are guaranteed to be pure.

The present invention provides a method for catalytic reduction of m-nitroacetophenone for preparation of m-aminoacetophenone, according to the method, hydrogen is used as a reducing agent, bismuth-compound-supported Pt is used as a catalyst, and the m-nitroacetophenone is highly-selectively reduced into the m-aminoacetophenone by a batch-type one-step reaction. The method reaction temperature is 30-120 DEG C, the reaction time is 1-20 hours, and the hydrogen partial pressure is 0.05-2.0MPa. The catalyst system can be used for efficiently catalytic hydrogenation of the m-nitroacetophenone, the m-aminoacetophenone yield is high; the hydrogen is used as the reducing agent, a main by-product is water, the method is green and environmentally-friendly; reaction conditions are mild, hydrogenation process equipment requirements are low, operation is simple; product separation and purification are simple, and the number of reusing times of the catalyst is high.

The invention relates to a synthesizing process of 3-methyl-1 H-indazole. The synthesizing process comprises the following steps: acetophenone is dropped into a sulfuric acid and nitric acid mixture solution, then calcium metasilicate powder is added, the mixture is kept to be stirred at lower temperature and passes through the night, the mixture is added into ice water and filtered, and 2-nitroacetophenone is obtained; the 2-nitroacetophenone, iron powder and ammonium chloride are synthesized into white solid 2-aminoacetophenone; the 2-aminoacetophenone is added to hydrochloric acid, then an NaNO2 aqueous solution is added, the mixture is stirred, then a hydrochloric acid solution of SnCl2.H2O is added, the mixture is stirred, the mixture is added to ice water and filtered, and filtrate is adjusted to alkalescence, filtered and dried so that the 3-methyl-1 H-indazole is obtained. According to the synthesizing process of the 3-methyl-1 H-indazole, calcium silicate is taken as a catalyst, the yield of the 2-nitroacetophenone is increased remarkably, the raw material of calcium silicate is easy to obtain, the cost is low, the operation and the use are simple, later synthesis of 2-aminoacetophenone and the 3-methyl-1 H-indazole is further facilitated, and the synthesizing process is suitable for industrial large-scale synthesis of 3-methyl-1 H-indazole.

The invention discloses a preparation method of o-aminoacetophenone. The preparation method comprises the following steps: (1) mixing o-nitroethylbenzene, an oxidant, a cocatalyst and an organic solvent, heating the obtained mixed solution to a certain temperature for a reaction, and subjecting the reacted solution to cooling, quenching and extracting to obtain o-nitroacetophenone; and (2) addinga polar solvent and a metal catalyst into the obtained o-nitroacetophenone, carrying out a hydrogenation reduction reaction to obtain a crude o-aminoacetophenone product, and filtering and rectifyingthe crude o-aminoacetophenone product to obtain a refined o-aminoacetophenone product. According to the invention, used raw materials are low in price and easy to obtain, and steps are simple and easyto operate. The o-aminoacetophenone obtained by the method disclosed by the invention is high in purity and high in yield.

The invention belongs to the field of food safety and standard substance synthesis, and discloses a synthetic method of deuterium-labeled D9-clenbuterol hydrochloride. According to the method, 4-amino-3,5-dichloroacetophenone is taken as a raw material and subjected to three-step reaction including bromination, D9 tert-butyl amination and reduction, and deuterium-labeled D9-clenbuterol hydrochloride is generated. The method is simple to operate, reaction conditions are mild (most reactions are performed at room temperature), reaction routes are reasonable, the process is advanced, the processing method is simple, and a product is easy to purify. Meanwhile, the total conversion rate of D9-tert-butylamine as the core raw material in the synthesis process of D9-clenbuterol hydrochloride is increased to 40% from 4.2%, yield is increased to 64%, and the method has good economic value and social value.