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Medicine composition with function of lowering blood sugar level as well as preparation method and application thereof

A composition and blood sugar-lowering technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that do not involve the extraction and preparation of α-glucosidase inhibitors, do not involve joint use, and do not involve Combined use of alkaloids and amino acids to achieve a clear mechanism of action and definite curative effect

Active Publication Date: 2010-12-29
GUANGDONG YIHETANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent ZL97112359.4 discloses "Application of Alcohol and / or Water Extract of Ramulus Mori in the Preparation of Hypoglycemic Drugs", this patent involves polysaccharides prepared from Mori Mori, but does not involve alkaloids and amino acids for hypoglycemic effect
Chinese Patent Application No. 98807147.9 introduces "Treatment of Diabetes with Thiazolidinedione, Insulin Secretagogue and α-Glucosidase Inhibitor", but this patent application does not involve how to extract and prepare α-Glucosidase Inhibitor from traditional Chinese medicine It does not involve the hypoglycemic effect of amino acids, nor does it involve the combined use of the above-mentioned alkaloids and amino acids
Chinese patent ZL01113191.8 discloses "Chinese medicine extract with α-glucosidase inhibitor activity, its preparation method and application", which involves the total alkaloids prepared from the traditional Chinese medicine Morus alba, mulberry leaves, mulberry branches or mulberries , but does not involve the hypoglycemic effect of amino acids, let alone the combined use of the above-mentioned alkaloids and amino acids
Chinese Patent No. ZL200410018677.4 discloses "Pharmaceutical Compositions with α-Glucosidase Inhibitory Activity and Uses thereof", which involves the extraction of total alkaloids and total Flavonoids, but not involving the hypoglycemic effect of amino acids, let alone the combined use of the above-mentioned alkaloids and amino acids
Chinese Patent Application No. 200510028709.3 discloses "a traditional Chinese medicine extract with hypoglycemic effect and its preparation method". Sugars, flavonoids and alkaloids, but not related to the hypoglycemic effect of amino acids, let alone the combined use of the above alkaloids and amino acids

Method used

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  • Medicine composition with function of lowering blood sugar level as well as preparation method and application thereof
  • Medicine composition with function of lowering blood sugar level as well as preparation method and application thereof
  • Medicine composition with function of lowering blood sugar level as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 2.50 kg of Cortex Mori, cut into shreds, add 37.5 L, 25 L, and 12.5 L of water respectively, extract dynamically at 80°C three times, filter, and discard the dregs. Combine the filtrates three times, concentrate to a certain volume, and centrifuge at high speed, adjust the pH value of the liquid to 4.0 with 1.0mol / L hydrochloric acid solution, then centrifuge at high speed, put the supernatant on a 001×7 cation exchange resin column, and wash with water to remove the non-adsorbed Impurities were then eluted with 1.0 mol / L ammonia solution, and the positive fractions in the alkaloid identification reaction and amino acid identification reaction were collected. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was vacuum-dried to obtain 26.40 g of extract, which contained 7.30 g of total alkaloids and 10.60 g of total amino acids, see Table 1 for details. Take 26.40g of extract, add 2.64g of crospovidon...

Embodiment 2

[0036] Weigh 2.50kg of Cortex Mori, crush it into a coarse powder, add 0.01mol / L hydrochloric acid solution at room temperature and dynamically extract twice, 25L each time, filter, and discard the dregs. Combine the two filtrates, concentrate to a certain volume, and centrifuge at high speed. The centrifugal supernatant is directly applied to the Amberlite IR120 cation exchange resin column, and the non-adsorbed impurities are washed with water first, and then eluted with 1.0mol / L ammonia solution to collect the alkaloid identification reaction. And amino acid identification reaction positive part. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was freeze-dried to obtain 31.35 g of extract, which contained 13.35 g of total alkaloids and 10.50 g of total amino acids, see Table 1 for details. Take 31.35g of extract, add 10.95g of crospovidone, 24.09g of microcrystalline cellulose, and 6.57g of silicon dioxide, m...

Embodiment 3

[0038] Weigh 2.50 kg of mulberry branches, slice them, add 25 L, 20 L, and 15 L of methanol respectively, heat and reflux for extraction three times, filter, and discard the medicinal residues. Combine the three filtrates, concentrate to dryness, add 12.5 L of deionized water, stir to dissolve it fully, let it stand for 30 minutes, and centrifuge at high speed, adjust the pH value of the centrifugal supernatant to 5.0 with 0.1mol / L sulfuric acid solution, filter under reduced pressure, and the filtrate Put it on the D001 cation exchange resin column, wash the non-adsorbed impurities with water first, and then elute with 0.2mol / L ammonia solution to collect the positive part of the alkaloid identification reaction and amino acid identification reaction. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was vacuum-dried to obtain 24.30 g of extract, which contained 5.05 g of total alkaloids and 7.25 g of total amino ...

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Abstract

The invention discloses a medicine combination with the function of lowering blood sugar level as well as a preparation method and application thereof. The existing medicines for lowering blood sugar level are mostly western medicines which have certain dependence and side effect. The active ingredients of the medicine combination comprises total alkaloid and total amino acid which are extracted and separated from any one or the composition of moraceae plants such as cortex mori radicis, ramulus mori, folium mori and mulberry; in all active ingredients of the extractive obtained from extraction and separation, the mass percentage of the total alkaloid is 9.8%-44.6%, the mass percentage of the total amino acid is 30.0%-70.4% and the combined content of the two account for more than 50% of the mass percentage composition of the extractive. In the invention, the total alkaloid and the total amino acid, the active ingredients extracted from the traditional Chinese medicine can achieve noticeable effect through combined use, features in fine synergistic effect and enjoys better blood-sugar-level lowering effect than when the total alkaloid and the total amino acid are independently used.

Description

technical field [0001] The invention relates to medicines containing traditional Chinese medicine extracts, in particular to a medicine composition with hypoglycemic effect, its preparation method and application. Background technique [0002] Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia caused by insufficient insulin secretion and / or impaired insulin action. It is manifested as elevated glucose concentration in blood and urine, and protein metabolism disorder. When blood sugar and urine sugar are too high, symptoms of "three excesses and one less" may appear, that is, polydipsia, polyphagia, polyuria and weight loss, accompanied by fatigue and weakness. Diabetes is mainly divided into type I diabetes (type 1diabetes), type II diabetes (type 2diabetes) and gestational diabetes (gestational diabetes). Among them, type I diabetes is the absolute lack of insulin caused by the destruction of pancreatic β cells, and must rely on insulin ther...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P3/06A61K31/445A61K31/198
Inventor 胡礼勇张利锋王光强
Owner GUANGDONG YIHETANG PHARMA CO LTD
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