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Natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and work method thereof

A separation method, two-dimensional chromatography technology, applied in the direction of material separation, instruments, scientific instruments, etc., can solve problems such as insufficient automatic control of systematic separation, and achieve the effect of improving efficiency

Active Publication Date: 2016-09-14
朱靖博
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  • Application Information

AI Technical Summary

Problems solved by technology

The problem has been solved to a certain extent, but there are still deficiencies in the development of separation methods, separation efficiency and reproducible acquisition of effective parts, systematic separation of effective parts and automatic control of the separation process

Method used

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  • Natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and work method thereof
  • Natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and work method thereof
  • Natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and work method thereof

Examples

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Effect test

Embodiment

[0031] Example: Systematic two-dimensional chromatographic separation and preparation of water-soluble substances in Chinese medicinal licorice

[0032] This embodiment is only limited to a further detailed description of the present invention, rather than limiting the present invention.

[0033] The separation of strong polar compounds is a difficult point in the separation of chemical components of traditional Chinese medicine. In view of the wide application of reversed-phase C18 chromatography and hydrophilic chromatography are often used as a supplement to reversed-phase chromatography for the separation of strong polar compounds, the use of both chromatography Orthogonality of separation, systematic separation and preparation of water-soluble components of traditional Chinese medicine licorice. .

[0034] In this example, the XIon / C18 two-dimensional online separation mode is used to separate the licorice water-soluble sample. The specific process is as follows:

[003...

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Abstract

The invention discloses a natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and a work method thereof, belongs to the technical field of natural medical component separation, and can be applied to development fields such as traditional Chinese medicine, plant drugs, marine drugs, and the like. The chromatographic instrument comprises a control system, a pumping system, an injection system, a detection system, a one-dimensional chromatographic column system, a two-dimensional chromatographic column system, and a two-position eight way valve. Separation method development and optimization and natural drug two-dimensional orthogonal chromatogram separation and preparation can be achieved in one instrument. Complicated natural products are separated into 18 components or effective parts that can be repeatedly obtained. Then 18 components or effective parts are subjected to two-dimensional separation to further separate the components or effective parts so as to obtain pure compounds. All separation operations are carried out under the control of a computer, the efficiency for separating and preparing natural drugs such as traditional Chinese herbals is greatly improved, and an efficient and reliable platform is provided for separating the effective parts and components from traditional Chinese herbals, plant drugs, and marine drugs and carrying out active screening.

Description

technical field [0001] The invention relates to a natural medicine two-dimensional preparation chromatographic instrument integrating separation method development, online separation-enrichment and its working method, which belongs to the technical field of separation of natural medicine components and is applied to the research and development of herbal medicines, traditional Chinese medicines, marine medicines, etc. field. Background technique [0002] The importance of chromatographic separation technology for the separation and preparation of natural products from plants, marine organisms, traditional Chinese medicine and bioengineering for the research of innovative drugs and fine chemicals is beyond doubt. The key to the creation of new drugs based on traditional Chinese medicines and the discovery and mechanism research of pharmacologically active ingredients in traditional Chinese medicines is the repeatable and systematic separation and preparation of active ingredi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/89
CPCG01N30/89
Inventor 朱靖博
Owner 朱靖博
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