Preparation of sinomontanine and its hydrobromide

Abstract

Preparation of sinomontanine A and its hydrobromic acid salt are disclosed. The procedure is carried out by crushing block root of Gaowutou, extracting by alcohol reflux or acid water leakage or alcohol immersion, concentrating to thin paste to obtain crude extract, acidifying crude extract to pH=1-5, obtain acidified liquid, adsorbing the acidified liquid by exchange resin cation or macroporous adsorbing resin or alumina, washing by water, washing by chloroform or/and alcohol, collecting eluent, concentrating extractive, dissolving the extractive into alcohol, laying aside for 1 day, crystallizing and washing by alcohol to obtain final product. It has higher purity.

Description

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AI Technical Summary

Benefits of technology

This patented method allows for efficient extracting highly pure compounds from plants without damaging them or causing harmful side-effects on their healthy cells during production processes.

Problems solved by technology

This patented describes methods for producing certain compounds called cobaltosides or conotoxanes that are found naturally throughout China's South America. These natural products can be useful drugs because they have analgesia properties similar to opiates like morphines. However, these chemical structures may also cause side effects such as abuse potential if consumed by someone who doesn’t want them themselves. Therefore it would make sense to develop new ways to produce this type of molecule more efficiently while reducing its harmful impact on human health during consumption.