The present invention relates generally to novel genetic sequences which
encode fatty acid epoxygenase enzymes. In particular, the present invention relates to genetic sequences which
encode fatty acid DELTA12-epoxygenase enzymes comprising mixed function
monooxygenase enzymes. More preferably, the present invention provides cDNA sequences which
encode plant fatty acid epoxygenases, in particular the Crepis palaestina
DELTA12-epoxygenase and homologues, analogues and derivatives thereof. The genetic sequences of the present invention provide the means by which
fatty acid metabolism may be altered or manipulated in organisms such as yeasts, moulds,
bacteria, insects, birds, mammals and plants, in particular to convert unsaturated fatty acids to epoxygenated fatty acids therein. The invention extends to genetically modified oil-accumulating organisms transformed with the subject genetic sequences and to the oils derived therefrom. The oils thus produced provide the means for the cost-effective raw materials for use in the efficient production of coatings, resins, glues, plastics, surfactants and lubricants, amongst others.