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Medicine composition for treating heart failure and application thereof

A heart failure and composition technology, applied in the field of pharmaceutical compositions for the treatment of heart failure, to achieve the effects of preventing and treating heart failure, reducing adverse reactions, and protecting myocardial mitochondria

Inactive Publication Date: 2015-03-25
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the use of plesantrin or the combination of plesantrine and trimetazidine for the treatment of heart failure and other heart diseases

Method used

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  • Medicine composition for treating heart failure and application thereof
  • Medicine composition for treating heart failure and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Experimental study on the effect of trimetazidine in combination with kaleidoxine on cardiomyocyte apoptosis in rats with heart failure

[0015] 60 clean SD rats, half male and half male, weighing 220-240 g. Rats were randomly divided into the following five groups: normal control group, model control group, trimetazidine group, quinhuasu group and combination drug group, with 12 rats in each group. The normal control group was subcutaneously injected with normal saline, and the rest of the rats were subcutaneously injected with isoproterenol at 45 mg / kg per day to establish the model for 2 consecutive days; after 4 weeks, the left ventricular ejection fraction (LVEF) was measured with a color ultrasound monitor, and LVEF≤ 45% were successful in modeling.

[0016] The model control group was given intragastric administration of distilled water every day after the modeling, and the Esperanthin group was given intragastric administration of 80 mg / kg of Esperant...

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PUM

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Abstract

The invention discloses a medicine composition for treating heart failure and application thereof. The medicine composition is prepared from an active ingredient and medicinal auxiliaries, wherein the active ingredient comprises (1) tortuosine and (2) trimetazidine or medicinal salt thereof. The medicine composition can be used for synergistically resisting myocardial apoptosis and protecting cardiac muscle mitochondria so as to achieve the aim of preventing and treating heart failure.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating heart failure and its application, belonging to the technical field of medicine. Background technique [0002] Heart failure (HF), also known as "myocardial failure", refers to the inability of the heart to pump out the blood supply commensurate with venous return and body tissue metabolism. Often caused by various diseases, the ability of myocardial contraction is weakened, so that the blood output of the heart is reduced, which is not enough to meet the needs of the body, and a series of symptoms and signs are produced. Cardiac valve disease, coronary arteriosclerosis, hypertension, endocrine disorders, bacterial toxins, acute pulmonary infarction, emphysema or other chronic lung diseases can all cause heart disease and lead to heart failure. Pregnancy, fatigue, rapid intravenous infusion, etc. can increase the burden on the diseased hea...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P9/04A61K31/475
CPCA61K31/495A61K31/475
Inventor 巩霞徐嬉平付海霞陈晓妹
Owner QINGDAO MUNICIPAL HOSPITAL
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