The invention relates to a ranolazine sustained release tablet medicine composition and a preparation method thereof. The composition comprises, by weight, 50%-72% of ranolazine, 20%-25% of pH dependence binding agents, 5%-8% of non-pH-dependence binding agents, 2%-15% of microcrystalline celluloses, 0.1%-0.5% of magnesium stearate and 0.1%-0.5% of sodium hydroxide. The preparation method includes the steps of mixing, palletizing, particle wrapping, drying, tidying, tabletting, tablet core wrapping and the like. The preparation method s easy and convenient, industrialization is easily achieved, and the prepared ranolazine sustained release tablet medicine composition has the beneficial effects of being good in slow-release effect, light in tablet weight and the like.