31 results about "Amiodarone" patented technology

Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti-arrhythmia drugs are incorporated along with an anti-inflammatory agent into hydrogels that biodegrade and adhere to the tissues to which the anti-arrhythmic drugs are to be delivered. The hydrogels may be formed in vitro or in vivo. In a preferred embodiment, the drugs are effective to lengthen atrial effective refractory period and minimize the inflammatory response. A particularly preferred drug is amiodarone and dexamethasone.

Methods and systems for treating patients suffering from or at risk of cardiac arrhythmias rely on the injection of amiodarone and other class III anti-arrhythmic drugs into the perivascular space surrounding a cardiac blood vessel. Injection may be achieved using intravascular catheters which advance needles radially outward from a blood vessel lumen or by transmyocardial injection from an epicardial surface of the heart.

The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns methods of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. This results in an improved safety profile. The new compounds have particular utility for treating life-threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The compounds also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.

The invention encompasses ready to administer liquid formulations including amiodarone and a substituted cyclodextrin. The invention also encompasses methods of making the liquid formulations to provide acceptable concentrations of amiodarone suitable for parenteral administration. The liquid formulations of the invention are formulations included, for example, in a ready to use intravenous bag, bottle or syringe.

The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns methods of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. This results in an improved safety profile. The new compounds have particular utility for treating life-threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The compounds also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.

The presently disclosed subject matter provides a pharmaceutical composition and a method of treating Chagas disease. The pharmaceutical composition includes a dose of Itraconazole and a dose of Amiodarone and may be in the form of a liquid oral suspension. The liquid oral suspension may be produced through the use of pharmaceutically acceptable beads. In addition, the Itraconazole may be micronized to a small particle size before being formed into a composition with Amiodarone. The method for treating Chagas disease is effected by administering an effective amount of this pharmaceutical composition to a subject in need thereof, and the present composition is safer and more effective than previous compositions and with fewer undesirable side effects.

The invention discloses a drug screening model for treating arrhythmia diseases. The drug screening model comprises in vitro cardiac myocytes and a suspending medium, wherein the suspending medium is formed by NaCl, CaCl2, KCl, glucose, hydroxypropyl methyl cellulose, hydroxyethyl piperazinyl ethanesulfonic acid and water. The concentration of the NaCl is 3.7 mM-88.8 mM in the suspending medium; the concentration of the CaCl2 is 0.08 mM-1.8 mM in the suspending medium; the concentration of the KCl is 3 mM-12 mM in the suspending medium; the concentration of the glucose is 108.1 mM-246 mM in the suspending medium; the concentration of the hydroxypropyl methyl cellulose is 0.5 mM-0.54 mM in the suspending medium; and the concentration of the hydroxyethyl piperazinyl ethanesulfonic acid is 20 mM in the suspending medium. Through experimental evidence, the drug screening model of the invention can be used for screening out propafenone and amiodarone (which are both conventional drugs for treating the arrhythmia diseases). Therefore, the drug screening model of the invention has wide application prospect in the field of screening the drugs for treating heart-related diseases.

The invention provides a method for synthesizing an amiodarone impurity G and application of the amiodarone impurity G, and relates to the technical field of chemical synthesis. According to the method for synthesizing the amiodarone impurity G, the amiodarone impurity G can be synthesized by one-step reaction of 3-bromo-2-(1-methoxybutyl)benzofuran and 4-(2-(diethylamino)ethoxy)-3,5-diiodobenzoyl chloride which are adopted as raw materials under protection of inert gas. The method is easy to operate and low-cost, and has certain commercial value. In addition, when the amiodarone impurity G synthesized by the method is used as an impurity reference substance, a qualified, low-cost and readily-available reference substance is provided for quality control over amiodarone, and great guiding significance is provided for safe medication.

The present invention provides a parenteral dosage form consisting essentially of a solution filled in a container, the solution comprising amiodarone or its pharmaceutically acceptable salt and a sulfo-alkyl ether beta-cyclodextrin in an aqueous vehicle, wherein the solution has a pH in the range of about 2.4 to 3.9 and further wherein the dosage form is sterilized by subjecting the filled container to autoclaving.

The invention relates to a plant extract for treating bradycardia, which is an oral preparation prepared from the extract of radix aconitilateralis preparata as the raw material, wherein the extract of radix aconitilateralis preparata is obtained by water extraction and alcohol deposition treatment. Pharmacodynamic tests and clinical practice of many kinds of chronic heart rate models prove that the extract can obviously raise the heart rate of bradycardia, and especially raise the heart rate of bradycardia caused by amiodarone. The total effective rate can reach more than 90%, the average heart rate increases 5-15 times / minute, the lasting period is long, and the extract can be repeatedly used without obvious adverse reaction.

The invention discloses an automatic injection pump. The automatic injection pump comprises an injection pump body, wherein the injection pump body comprises a controller and a plurality of groups of actuating mechanisms and injectors, and the injectors are respectively filled with epinephrine, anti-ventricular fibrillation or pulseless ventricular tachycardia drug amiodarone and normal saline. The controller can control the actuating mechanisms to drive the epinephrine injectors to inject once every 3-5 minutes, can control the actuating mechanisms to drive the amiodarone injectors to inject, and can control the actuating mechanisms to drive the injectors filled with normal saline to inject once after medicine injection is completed every time. The automatic injection pump further comprises an operation panel, wherein an epinephrine starting button and an amiodarone starting button are arranged on the operation panel. According to the automatic injection pump, through automatic control of an automatic process, injection in a specified process can be accurately and automatically carried out or is manually carried out upon reminding, and rescue medicine can be well injected instead of manual operation; and meanwhile, the injection process can be automatically or manually started upon a reminding according to changes in vital signs of a patient.

The present disclosure relates generally to treating or preventing diseases associated with angiogenesis by administering to a patient certain compounds found to inhibit or substantially reduce angiogenesis. Compounds employed according to the present disclosure exhibit good anti-angiogenic activity as well as demonstrate a prophylactic effect for preventing and substantially reducing angiogenesis. Examples of such compounds include Ritanserin, Amiodarone, Terfenadinc, Perphenazine, Bithionol, and Clomipramine.

Antifungal compounds having a benzofuran structure. Antifungals exhibit much less toxicity to human cells than amiodarone. These compounds are useful alone or in combination with other compounds having antifungal activity. Compounds of this invention exhibit synergistic antifungal activity in combination with antifungal amiodarone compounds. The invention provides pharmaceutical compositions useful for treating fungal infections, methods for treating fungal infections and compounds useful in such compositions for treating fungal infections. Compounds of this invention are further useful as antifungal agents for the prevention and or treatment of fungal infections in plants. The invention includes agriculturally useful compositions comprising one or more compounds of this invention which exhibit fungistatic or fungicidal function against one or more plant pathogen is a fungus.

The presently disclosed subject matter provides a pharmaceutical composition and a method of treating Chagas disease. The pharmaceutical composition includes a dose of Itraconazole and a dose of Amiodarone and may be in the form of a liquid oral suspension. The liquid oral suspension may be produced through the use of pharmaceutically acceptable beads. In addition, the Itraconazole may be micronized to a small particle size before being formed into a composition with Amiodarone. The method for treating Chagas disease is effected by administering an effective amount of this pharmaceutical composition to a subject in need thereof, and the present composition is safer and more effective than previous compositions and with fewer undesirable side effects.

The invention discloses a culture method and detection method for rat fibrotic lung cells. The culture method and detection method for rat fibrotic lung cells comprise the following steps: preparing a culture solution, a perfusion fluid and a rinsing solution; then sampling rat type II alveolar epithelial cells and carrying out primary culture; stimulating the type II alveolar epithelial cells with amiodarone so as to obtain fibrotic lung cells; and detecting the fibrotic lung cells. The culture method provided by the invention can acquire a great number of cells in a short period of time and accurately reflect the condition of amiodarone-induced pulmonary fibrosis in vivo and is of great significance to deep research on the influence of regulation and mechanism of the phenotypic transformation of the type II alveolar epithelial cells to delaying, or even reversion, of amiodarone-induced pulmonary fibrosis, and provides a research object for further exploration of the pathogenesis of amiodarone-induced pulmonary fibrosis at cell and molecule levels.

The present invention relates to a compound Huangyangning dropping pill for curing angiocardiopathy and cerebrovascular disease. It comprises Huangyangning (a Chinese herbal medicine), borneol and medicinal excipient, in whith the dosage ratio of Huangyangning and borneol is 1:0.1-0.5. Said invented dropping pill dosage for can make the medicine effect quickly produce action, its biological utilization rate is high and its side effect is less. The tests show that it is superior to amiodarone and Huangguangning tablet preparation in the therapeutic effect.