The invention discloses an injection-purpose
medicine composition for improving stability of ligustrazine
medicine injection formulation and a preparation method of the injection-purpose
medicine composition. The injection-purpose medicine composition is prepared by the method comprising following steps: dissolving ligustrazine salt in water for injection, adjusting the pH value of the liquid medicine by adding
citric acid and / or
sodium citrate used as a pH
regulator, wherein the dosage of the
citric acid and / or
sodium citrate ranges from (0.1mg to 200.0mg) / 100ml. In the invention, pH value of the injection liquid can be more stable, the content of ligustrazine degradation substance is greatly reduced compared with that of the prior art, the
clarity of the ligustrazine injection liquid is improved under the condition of not using other cosolvents to increase the clinical application risk, particularly, the problems of small
white spots, white blocks and solution
turbidity are solved under the condition that the ligustrazine injection liquid is stored for a long time by adopting the prior art, and the medicine composition ensures that the inspection of visible foreign substances of the product is in accordance to the formulation of medicine
quality standard, and is convenient for clinical medication and popularization.