344results about How to "Reduce efficacy" patented technology

The present invention relates to pyrazinoylguanidine compounds represented by formula (I): where at least one of R3 and R4 is a group represented by formula (A): where the other structural groups are defined herein. The present invention also includes a variety of methods of treatment using these sodium channel blockers.

The present invention relates to compounds represented by formula (I):in which at least one of R3 and R4 is a group represented by formula (A):where the structural variables are defined herein. The compounds are useful for blocking sodium channels.

The present invention provides compound represented by formula (I):where the structural variables are defined herein. The compounds function as sodium channel blockers and may be used to treat a variety of respiratory conditions.

The present application provides sodium channel blockers exemplified by the following structure:The compounds of the invention useful for treating chronic bronchitis, cystic fibrosis, sinusitis, vaginal dryness, dry eye, Sjogren's disease, distal intestinal obstruction syndrome, dry skin, esophagitis, dry mouth (xerostomia), nasal dehydration, ventilator-induced pneumonia, asthma, primary ciliary dyskinesia, otitis media, chronic obstructive pulmonary disease, emphysema, pneumonia, constipation, and chronic diverticulitis, for example.

The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas combined with pyriproxyfen.

Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and / or treat disease, especially virus-induced diseases, are also disclosed.

The invention relates to certain compounds according to Formula (I):or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders and immune disorders.

The invention belongs to the field of a fertilizer, in particular to a potassium humate compound fertilizer and a preparation method thereof. The potassium humate compound fertilizer is prepared by mixing urea, potassium humate, monoammonium phosphate, ammonium chloride, calcium powder and bentonite with magnesium sulfate, zinc sulfate and medium / trace elements. The potassium humate compound fertilizer granulated by using a steam drum physical agglomeration method and the preparation method of the compound fertilizer have the advantages that the prepared potassium humate compound fertilizer has large particle size and high strength and does not agglomerate; the capabilities of water and fertility retention, heat preservation and ventilation of the soil are enhanced; the soil structure is improved; the soil fertility is increased; the problems of reduced soil fertility, environmental pollution, soil hardening, nutrition unbalance and stress resistance of crops are solved; the utilization rate of the fertilizer is improved; the defects of low fertilizer efficiency, insufficient nutrition utilization, overproof pesticide residue, severe nitrate accumulation and heavy metal pollution are overcome; the sustained-release effect against pesticide is realized; the agroecological environment is protected; and the efficiency, yield and crop quality are improved.

The present application discloses methods for treating patients with a dysfunction of the ion channels of the heart suffering from one or more cardiovascular diseases to reduce the proarrhythmic effect of drugs and / or conditions that reduce or inhibit IKr.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine(dinotefuran), an aldulticide that will kill adult fleas combined with methoprene.

An orally-applied ranolazine hydrochloride for treating cardiovascular disease is prepared from ranolazine hydrochloride, diluent, adhesive, disintegrant, antisticking agent and lubricant through adding wetting agent, preparing soft material, granulating and drying.