63 results about "Methylguanidine" patented technology

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas combined with methoprene.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas combined with pyriproxyfen.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine(dinotefuran), an aldulticide that will kill adult fleas, dissolved in a solvent such as ethanol and/or DPM.

Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation. As a result, TAT complexes can be precisely assayed while circumventing the effect of heparin. The polycation is, for example, hexadimethrine bromide, chitosans, modified dextran, aminodextran, hydroxymethyl cellulose trimethylamine, lysozyme, spermine, spermidine, polylysine, polyarginine, polyornithine, protamine sulfate, hydroxyethyl cellulose trimethylamine, heparin-binding protein, polyallylamine, polyallylamine hydrochloride, poly(diallyl dialkyl amine), polyamideamine, polyamine, polyvinylbenzyltrimethylammonium chloride, polydiallyldimethylammonium chloride, polyethyleneimine, polypropyleneimine, polypropylethyleneimine, polyimidazoline, polyvinylamine, polyvinyl pyridine, poly(acrylamide/methacryloxypropyltrimethylammonium bromide), poly(diaryldimethylammonium chloride/N-isopropylacrylamide), poly(dimethylaminoethyl acrylate/acrylamide), poly(dimethylaminoethyl methacrylate), polydimethylaminoepichlorohydrin, polyethyleneiminoepichlorohydrin, polymethacryloxyethyl-trimethylammonium bromide, hydroxypropylmethacryloyloxyethyl dimethyl ammonium chloride, poly(methyldiethylaminoethylmethacrylate/acrylamide), poly(methyl/guanidine), polymethylvinylpyridinium bromide, poly(vinylpyrrolidone-dimethylaminoethyl methacrylate), or polyvinylmethylpyridinium bromide.

The invention discloses a pancreatic cancer diagnostic marker combination as well as application and a determination method thereof. The pancreatic cancer diagnostic marker combination comprises 15 differentiated metabolites (2,5-dihydroxybenzoic acid, talopyranose, proline, glutamate, choline, 1,5-anhydro-D-glucitol, tryptophan, glutamine, betaine, 2-oxoglutaric acid, methylguanidine, adenine, glycocholic acid, valine and 2-aminobutyric acid). The invention further provides a combination of the 15 differentiated metabolites to serve as a marker for early discovery and diagnosis of pancreatic cancer, application and a diagnostic marker determination method, and the method is a liquid-phase/gas-phase chromatography-mass spectrometry combined metabonomics analysis method based on plasma/serum of patients with pancreatic cancer. The pancreatic cancer diagnostic marker combination provided by the technical scheme of the invention has the characteristics of being high in sensitiveness and specificity, has relatively high sensitiveness and specificity on early pancreatic cancer diagnosis, can be used for early discovery of pancreatic cancer, gains time for the patients to receive treatment as soon as possible, and improves the clinical treatment effect.

The invention discloses polyaspartic acid for a water treatment scale inhibitor. The structural formula of the polyaspartic acid is shown in formula I of the description, where x/(x+y) is more than or equal to 0.50 and less than or equal to 0.8. The preparation method for the polyaspartic acid comprises the following steps: performing contact reaction on polysuccinimide and a mixed base in the presence of triethanolamine and zinc acetate, and regulating the pH of a solution to 6 to 7 by virtue of hydrochloric acid, wherein the mixed base is prepared from potassium hydroxide and tetramethyl guanidine of which the mass ratio is (1 to 3):1. The polyaspartic acid is higher in scale inhibition performance and biological degradation performance and more environmentally-friendly.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.

The invention discloses a synthesis method for an intermediate of an impurity A of pemetrexed disodium and belongs to the field of drug synthesis. (4-(2-(2-amino-1-methyl-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidine-5-yl)ethyl)benzoyl)-L-glutamic acid is an impurity A of pemetrexed disodium, and 4-(2-(2-amino-1-methyl-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidine-5-yl)ethyl)methyl benzoate is an important intermediate required for synthesis of the impurity A. The synthesis method of the intermediate comprises the following steps: carrying out a reaction on a compound I 1-methylguanidine and a compound II ethyl cyanoacetate to obtain a compound III 2,6-diamino-4-carbonyl-1-methylpyrimidine, and carrying out a reaction on a compound IV 4-(4-carbonyl-3 brombutyl)methyl benzoate and the compound III to obtain a compound V 4-(2-(2-amino-1-methyl-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidine-5-yl)ethyl)methyl benzoate.

The invention relates to the field of preparation methods and application of compounds, in particular to a preparation method and application of N-bis (dimethylamino)-1, 3-dimethylimidazoline, whereinthe chemical molecular formula is C9H23N5. The preparation method comprises the following steps: S1, taking 1, 3-dimethyl-2-imidazoline and bis (trichloromethyl) carbonate as raw materials, and carrying out chlorination reaction to synthesize chlorinated 1, 3-dimethyl-2-chloroimidazoline; therefore, the problems of safety and environmental protection of other chlorinated reagents are solved, andthe product yield (87% or above) is greatly improved. S2, dropwise adding tetramethylguanidine into the generated chlorine salt, and carrying out condensation reaction; S3, carrying out neutralizationreaction on an obtained product to obtain N-bis (dimethylamino) methylene-1, 3-dimethyl-2-chloroimidazoline ammonium chloride salt. The process is high in operability, mild in reaction condition, safe, green, environmentally friendly, good in product catalytic effect and wide in application range, and almost no other impurities are generated except that high-content potassium chloride is generated as a byproduct.

The present invention relates to biocidal compositions comprising an isothiazolone biocidal active compound in combination with a guanidine adjuvant. These compositions are highly effective in preventing deterioration and decay caused by microbial contamination in very low concentrations so that the environmental or toxicological burden is low.

The invention discloses alkyl-substituted ethyl acetate-based guanidine ionic liquid as well as preparation and application thereof, which are characterized in that tetramethylguanidine and 2-bromo ester are ionized to obtain alkyl-substituted ethyl acetate-based guanidine ionic liquid, and the alkyl-substituted ethyl acetate-based guanidine ionic liquid is applied as a catalyst to formylation and methylation reactions of carbon dioxide, N-methylaniline and derivatives of the N-methylaniline to selectively generate N-methylformylaniline or N, N-dimethylaniline and derivatives thereof. Compared with the prior art, the alkyl-substituted ethyl acetate-based guanidine ionic liquid has the advantages of good catalytic performance, mild reaction conditions, simple post-treatment, simple synthesis, low cost, greenness and high efficiency, avoids the use of a large amount of organic solvents when being used as a solvent and a catalyst at the same time, and has important meanings in the research of medicinal chemistry and medical intermediate compounds.

The invention discloses a method for preparing a rosuvastatin calcium intermediate containing brooethyl, hydroxymethyl or formyl. The method includes enabling fluoro-acetophenone to be reacted with ethyl iso-butyrate to prepare a compound V, enabling the compound V to be reacted with methyl iodide to synthesize a compound as shown in a formula IV, then enabling the compound as shown in the formula IV to be reacted with methylguanidine hydrochloride and cesium carbonate to obtain a compound as shown in a formula III, enabling the compound as shown in the formula III to be reacted with triethylamine and methylsulfonyl chloride to prepare a compound as shown in a formula II, and finally enabling the compound as shown in the formula II to be reacted with NBS (N-bromosuccinimide) to obtain a compound as shown in a formula I; and then preparing a compound as shown in a formula I-1 and a compound in a formula I-2. Compared with an existing method, the method has the advantages of mild reaction conditions, cheap utilized reagents and high yield.

The invention belongs to the technical field of organic chemistry, and discloses a synthesis method of an abiraterone acetate highly finished product. The synthesis method comprises the following steps: sequentially adding absolute ethyl alcohol, hydrazine hydrate and glacial acetic acid in dehydroisoandrosterone 3-acetate (SM1), and preparing a reactant B at the temperature of 20-30 DEG C; addingtetrahydrofuran and iodine, slowly adding tetramethyl guanidine at the temperature of -5 to 5 DEG C, controlling the temperature to be 10 DEG C or below, and dropwise adding a tetrahydrofuran solution of the compound B at the temperature of -5 to 5 DEG C for 6 h to obtain a compound C; sequentially adding tetrahydrofuran, diethyl-(3-pyridine)borane, trans-dichlorobis(triphenyl-phosphine)palladiumand a tetrabutylammonium fluoride trihydrate in the compound C to obtain a compound D; and adding dichloromethane and 4-dimethylaminopyridine in the compound D, slowly adding acetic anhydride at thetemperature of 15-35 DEG C, and adding activated carbon and methanol-water after finishing the reaction to obtain a compound E, and highly finishing the compound E to prepare the abiraterone acetate highly finished product.

The invention discloses alkane macrocyclic and aza macrocyclic lactone compounds based on a natural product Argifin as well as a preparation method and application of the alkane macrocyclic and aza macrocyclic lactone compounds. The structural formulas of the compounds are shown as a formula I and a formula II. The compound has an inhibition effect on chitinase from Asiatic corn borer and serratia marcescens; the insecticidal composition has insecticidal activity on insects such as plutella xylostella and ostrinia furnacalis, and can be used for preventing and treating agricultural pests.