105results about How to "Enhance myocardial contractility" patented technology

The invention relates to a red date wine and a preparation method thereof. The red date wine is prepared by the components with the weight percentage as follows: 60 to 85 percent of Xinjiang ziziphus jujube cv. Huizao juice as well as 15 to 40 percent of Xinzheng ziziphus jujube cv. Huizao juice. The invention uses the advantages of red dates of different varieties to carry out composite mixing on the materials and employs secondary composite fermentation to brew the high quality red date fermentation wine with alcohol content larger than 20V / V. The red date wine fully applies and combines the medical value and fragrance of the Xinzheng ziziphus jujube cv. Huizao juice as well as advantage of the Xinjiang ziziphus jujube cv. Huizao juice that the high-sugar content is beneficial to fermentation; the primary fermentation of grape wine dry yeasts is beneficial to generating the fruit fragrance, the nutrition and the pigment of the red date; the aroma-producing yeast employed by after fermentation of the grape wine dry yeasts has the advantages of producing grease, increasing fragrance, removing foreign flavors, and leading a wine body to be full and harmonious.

The invention discloses a Chinese medicine combination for treating cardio-cerebral vascular diseases, which is composed of raw materials with the following parts by weight: 30-50 parts of radix astragali, 20-25 parts of angelica, 15-20 parts of hemlock parsley, 30-50 parts of salvia miltiorrhiza, 15-20 parts of pseudo-ginseng, 15-20 parts of hawkthorn and 20-30 parts of radix puerariae; the Chinese medicine combination of the invention has ingenious compatibility, simple prescription, broad source of raw materials, low price as well as the efficacies of tonifying both qi and blood, balancing yin and yang, activating blood circulation and dissolving stasis; the Chinese medicine combination can soften blood vessels through reducing blood fat and blood viscosity and eliminating blood scales and finally achieve the purposes of smoothing blood circulation and activating cardio-cerebral function; furthermore, the Chinese medicine combination has unique efficacy for resisting atherosclerosis as well as significant curative effect on cardio-cerebral vascular diseases like coronary heart disease, cerebral thrombosis, and the like; the total clinical effective rate can reach over 95% and the Chinese medicine combination can achieve good preventive and health care effect through long-term oral administration and has safe oral administration and no toxicity and side effect.

The invention relates to a beverage, in particular to a honey pomelo tea beverage and a preparation method thereof. The tea beverage is characterized by being prepared from the following raw materials by weight: 1200-1500 parts of pomelos, 700-900 parts of hawthorn, 200-500 parts of salt, 200-500 parts of crystal sugar, 400-700 parts of honey, and 2500-3000 parts of water. The honey pomelo tea beverage provided in the invention has the characteristics of being sweet and sour and delicious, as well as nutrient-rich, and frequent drink can achieve the efficacy of promoting appetite and helping digestion, relieving dyspepsia, reducing phlegm and promoting the circulation of qi, softening blood vessels, lowering blood fat, and reducing cholesterol. Being suitable for people of all ages, the honey pomelo tea beverage disclosed in the invention is an ideal green beverage.

The invention discloses a hangover alleviating and liver protecting functional fermented beverage and a preparation method thereof, and belongs to the field of microbial fermentation application. Thefermented beverage consists of the following raw materials: 5-10g of red dates, 10-15g of kudzuvine root powder and the balance of water, wherein probiotics used for fermentation of the hangover alleviating and liver protecting functional fermented beverage are one of lactobacillus plantarum or pediococcus acidilactici. According to the invention, polysaccharides, vitamins, cellulose, phenolic substances, flavonoid substances and the like in red dates and kudzuvine roots exert a maximum effect through probiotic fermentation; the fermented beverage not only preserves the nutritional value of natural plants, but also has the nutritional and health-care effects of probiotic fermentation products; and the fermented beverage is unique in taste and obvious in effect and has a good market prospect.

A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

Disclosed are uses of neuregulin in the preparation of medicines for preventing, treating or delaying ventricular arrhythmia of a human being, and pharmaceutical preparations that comprise the neuregulin and are used for preventing, treating or delaying the ventricular arrhythmia.

A method of facilitating therapeutic neuromodulation of a heart of a patient includes positioning an electrode in a pulmonary artery, positioning a sensor in vasculature, delivering via a stimulation system first and second electrical signals of a series of electrical signals to the electrode. The second electrical signal differs from the first electrical signal by a magnitude of a first parameter of a plurality of parameters. The method includes determining via the sensor, sensor data indicative of one or more heart activity properties in response to the delivery of the series of electrical signals, and delivering a therapeutic neuromodulation signal to the pulmonary artery using selected electrical parameters. The selected electrical parameters include a selected magnitude of the first parameter. The selected magnitude of the first parameter is based at least partially on the sensor data. The therapeutic neuromodulation signal increases heart contractility.

A method of facilitating therapeutic neuromodulation of a heart of a patient includes positioning an electrode in a pulmonary artery, positioning a sensor in vasculature, delivering via a stimulation system first and second electrical signals of a series of electrical signals to the electrode. The second electrical signal differs from the first electrical signal by a magnitude of a first parameter of a plurality of parameters. The method includes determining, via the sensor, sensor data indicative of one or more heart activity properties in response to the delivery of the series of electrical signals, and delivering a therapeutic neuromodulation signal to the pulmonary artery using selected electrical parameters. The selected electrical parameters include a selected magnitude of the first parameter. The selected magnitude of the first parameter is based at least partially on the sensor data. The therapeutic neuromodulation signal increases heart contractility.

The invention relates to a capsule widely applied to medicine, healthcare products and food industries, and in particular relates to a functional vegetated substrate hollow capsule. The functional vegetated substrate hollow capsule is prepared by the steps of mixing cellulose and a coagulant aid which serve as base matrixes with a functional gelatinizing agent which is a mixture of auricularia auricular polysaccharide and flaxseed gum to obtain the raw material of the hollow capsule and preparing the raw material into the hollow capsule through a conventional hollow capsule preparation process. The functional vegetated substrate hollow capsule disclosed by the invention has a remarkable characteristic that the mixture of auricularia auricular polysaccharide and flaxseed gum, having a biological function, is used as the functional gelatinizing agent of the hollow capsule; the functional vegetated substrate hollow capsule prepared from the functional gelatinizing agent, cellulose biological matrix and coagulant aid has obvious functional characteristics unreachable for an existing gelatin hollow capsule; the functional vegetated substrate hollow capsule is widely applicable to medicine, healthcare products and food industries.

The invention provides an identification method for a fingerprint spectrum of an astragalus medicinal material. The method consists of: preparation of a test solution, measurement of a fingerprint spectrum, determination of a control fingerprint spectrum, and identification of an astragalus medicinal material fingerprint spectrum. By high performance liquid chromatography (HPLC) fingerprint spectrum measurement and analysis on the astragalus medicinal material, 9 characteristic peaks of the astragalus medicinal material can be determined, and the common characteristic peaks constitute fingerprint features of the astragalus medicinal material and can serve as the control fingerprint spectrum of the astragalus medicinal material. The astragalus medicinal material needing identification can be compared with the control fingerprint spectrum to inspect the situation of the common characteristic peaks so as to identify quality. With the characteristics of simplicity, good repeatability, obvious characteristic peaks, accuracy and reliability, etc., the method provided by the invention is conducive to identifying the quality of the astragalus medicinal material.

The invention relates to traditional Chinese medicine powder, in particular to traditional Chinese medicine powder for treating pig high fever and a preparation process of the powder. The traditional Chinese medicine powder comprises the following raw materials in percentage by weight: 5%-9% of astragalus membranaceus, 5%-9% of honeysuckle, 4%-8% of wild chrysanthemum flowers, 1%-4% of venenum bufonis, 8%-12% of isatis root, 6%-10% of houttuynia cordata, 4%-8% of sculellaria barbata, 3%-7% of bighead atractylodes rhizome, 3%-7% of divaricate saposhnikovia root, 5%-10% of raw gypsum, 4%-8% of cape jasmine, 5%-9% of fructus forsythiae, 5%-9% of scutellaria baicalensis, 5%-9% of polygonum cuspidatum, 3%-7% of pulsatilla root and 2%-6% of radix sophorae flavescentis. The powder is mainly used for treating various viral diseases, and has a very good effect on the pig high fever.

A method of detecting catheter movement includes positioning a first sensor in a first body cavity, monitoring a first parameter profile of the first body cavity, positioning a second sensor in a second body cavity, monitoring a second parameter profile of the second body cavity, the second parameter profile different than the first parameter profile at a first time, and, when the second parameter profile is the same as the first parameter profile at a second time after the first time, taking a catheter movement action.

The invention provides a cockroach extract, a preparation method thereof, and application of a cockroach extract preparation in treatment of cardiovascular disease. The cockroach extract comprises the following components (based on dry weight): 20-40% of composite nucleoside base, 30-60% of associated amino acid, 2-4% of uracil, 3-6% of hypoxanthine and 5-10% of inosine. The preparation method comprises the following steps of: pulverizing dried cockroach into coarse powder, carrying out percolation or reflux extraction with 90-95% ethanol to obtain dense paste, carrying out oil-water separation, and removing precipitate and oil to obtain water-layer drug liquid; and adsorbing with activated carbon, carrying out secondary alcohol extraction and water extraction, decolorizing, carrying out ultrafiltration and concentrating to obtain the cockroach extract dense paste. Combined with proper pharmaceutical auxiliary materials, the cockroach extract can be prepared into aqueous injection, freeze-dried powder injection, capsules, granules, tablets, oral liquid, dropping pills and other various dosage forms, and the obtained preparation can be used for treating cardiovascular disease, particularly heart failure caused by pulmonary heart disease, cardiomyopathy, rheumatism, coronary disease, high-altitude heart disease and the like.

A therapy delivery device for modulating cardiac function in a subject includes a counterpulsation component, an endovascular lead, and at least one electrode that is physically coupled with the endovascular lead. Each of the counterpulsation component and the endovascular lead includes a proximal end and a distal end. The proximal end of the endovascular lead is physically connected to the distal end of the counterpulsation component.

The invention is a calcitonin gene-related polypeptide (CGRP) derivative and its preparing method. CGRP has important physiologic functions of reducing blood pressure, etc, but is easy to degrade in animal bodies and has short acting time. It designs a segment of DNA sequence linked with the GST genes ofEscherichia coli particle carrier pGEX-4T-2, composing a new expression plasmid pGEX-CGRP with CGRP. It makes separation and extraction on the fusion protein produced by Escherichia coli fermentation to prepare CGRP derivative I. In addition, It clones the genes of the two decompressing small peptides: HHL and PRLKPW to CGRP genes, composing two expressing particles: pGEX-CGRP-3AA and pGEX-CGRP-6AA, transferred into the Escherichia coli cells, then fermenting and separating CGRP derivatives II and III from Escherichia coli cells. The above derivatives can be used in preparing the medicines of curing cardiovascular disease.

The present invention relates to methods and compositions for delivering a nucleic acid to be expressed in the myocardium of a patient. More specifically, the present invention relates to techniques and polynucleotide constructs for treating heart disease by in vivo delivery of angiogenic transgenes.

Techniques are described for use with an implantable cardiac stimulation device for performing paired / coupled pacing either alone or in conjunction with dynamic overdrive / underdrive pacing. In one technique, dynamic overdrive / underdrive pacing is delivered to the ventricles using paired pulses during an episode of atrial fibrillation. The use of paired pulses during dynamic ventricular overdrive / underdrive pacing helps lower and stabilize the ventricular rate to thereby reduce the risk of a ventricular arrhythmia. In another technique, the inter-pulse interval between paired pulses is optimized to lengthen the resulting refractory period to improve hemodynamics. Preferably, the optimized inter-pulse interval is used when applying dynamic ventricular overdrive / underdrive pacing with paired pulses so that the benefits of both techniques are obtained. The optimization technique is also applicable to setting the coupling interval for use with coupled pacing.

The present invention provides one kind of winter date bud tea and its production process. Winter date bud tea is produced with winter date bud and through depurating, washing, sieving, stoving, kneading in a kneading machine to shape, further stoving, drying with hot blast to water content of 6-12 %. Winter date bud tea has good look, dark green color, good taste and some health functions.

The traditional Chinese medicine composition for treating chronic congestive heart failure provided by the invention belongs to the technical field of Chinese herbal medicine preparation. The invention aims to solve a technical problem by providing a traditional Chinese medicine for treating chronic congestive heart failure, and the medicine can effectively control heart failure, and has little toxic or side effect. A technical scheme is as below: 6-9 parts of ginseng, 15-30 parts of Astragalus mongholicus, 9-12 parts of cassia twig, 9-12 parts of dried rhizome of rehmannia, 20-30 parts of root of red-rooted salvia, 20-30 parts of motherwort, 20-30 parts of Poria cocos, 15-20 parts of semen lepidii, 5-9 parts of Chinese silkvine root-bark,12-15 parts of root of common peony and 12-15 parts of Ligusticum wallichii. The traditional Chinese medicine provided by the invention has main effects of benefiting heart qi, promoting blood circulation to remove blood stasis, alleviating water retention, resolving phlegm, nourishing heart yin and helping the heart yang.

The present invention discloses a camellia nitidissima sugar lowering low-fat nutritious biscuit which belongs to the health-care food industry. The biscuit consists of the following raw materials in percentage by weight: camellia nitidissima 15-20%, pea flour 15-20%, sweet potato flour 12- 18%, corn flour 10-15%, red bean powder 5-10%, egg white 8-15%, corn germ oil 5-10%, oligomeric maltose 5-10%, baking powder 1-2%, baking soda 1-2%, edible salt 0.05-0.15%, citric acid 0.01-0.1%, and the balance water. The biscuit is prepared from the above materials according to the ratio, and specifically is prepared by extracting raw liquid, screening and selecting flour, stirring and mixing into a dough, rolling and shaping, baking, screening, and finally packaging. The camellia nitidissima sugar lowering low-fat nutritious biscuit is finely prepared by scientifically matching various types of coarse cereals and added raw materials with high nutritional value, maximumly maintains the essence ingredients and natural flavor of the coarse cereals, does not add any flavoring agent, maintains the natural grain flavor, has characteristics of excellent mouthfeel and rich nutrition, and is suitable for people who avoid sugar.

The invention discloses health herbal tea capable of improving immunity and a preparation method thereof. The herbal tea is prepared by the following steps: adding water, boiling processed bulk pharmaceutical chemicals, such as rehmannia glutinosa, dogwood, Chinese yam, Chinese-date, poria cocos, eucommia ulmoides, polygala tenuifolia, fried schisandra chinensis, fructus broussonetiae, fried foeniculum vulgare, morinda officinalis, herba cistanche, acori graminei rhizoma, wolfberry, and adding honey and white granulated sugar so as to prepare the health herbal tea. The health herbal tea provided by the invention can effectively strengthen the human immunity, reduce various immune diseases, such as the symptoms of influenza, weakness, improve the sub-health status obviously, can delay aging, remove dull yellow skin, and brighten skin to enable the skin to be smooth, white, fine and elastic.

The invention relates to an external percutaneous heart failure therapeutic instrument. A application method comprises detecting electrocardiogram signals through an electrocardiograph operated outside a human body, determining a ventricular refractory period through the electrocardiogram signals, and stimulating myocardium by releasing high-frequency electric waves to a heart by the external percutaneous heart failure therapeutic instrument at the ventricular refractory period to increase myocardial contractility. Compared with the prior art, the external percutaneous heart failure therapeutic instrument is advantaged in that the instrument not only solves a problem of European and American CCM machine electrode internal-placement causing injuries and a problem of external electrical stimulation tolerability.

The invention discloses a production method of high-efficiency keratinase. The method comprises the following steps: inoculating Leuconostoc mesenteroides into a slant culture medium by a coating or scribing process, and carrying out rejuvenation culture at 18-37 DEG C for 18-36 hours to obtain rejuvenated cells; inoculating the rejuvenated cells into a liquid seed culture medium, and culturing at 18-37 DEG C under the condition of 100-300 rpm for 18-36 hours to obtain a fermentation seed; and inoculating the fermentation seed, which accounts for 5-15 vol% of the fermentation culture medium, into a fermentation tank, and fermenting and culturing for 18-60 hours to obtain the high-efficiency keratinase, wherein the tank temperature is 18-37 DEG C, the tank pressure is 0.2-0.8 kg / cm<2>, the stirring rate is 100-300 rpm and the ventilatory capacity is 1:(0.3-2.0). The prepared keratinase is widely used in the fields of tanning unhairing and keratin hydrolysis.

The invention relates to a nutrient supplement for calcium supplementation, in particular to a multi-functional high-efficient calcium supplemental agent and a preparation method thereof which belong to the field of nutritious and health care products. The product of the invention selects inorganic calcium salt, L-ascorbic acid, L-aspartic acid for carrying out the reaction to prepare L-ascorbic acid-L-aspartic acid calcium; and the L-ascorbic acid-L-aspartic acid calcium can be prepared into health care foods with different forms such as tablets, granules, capsules, oral liquor and other after being added with necessary excipients. The product has good taste, no bitter taste and no gastrointestinal tract stimulation; the product has easy absorption, good safety and multiple nutritious health care functions. The product can more easily enter various parts of the human body through the passive diffusion, the transport or active transport and other different modes when in lack of calcium of the human body particularly, thereby meeting the needs on the calcium element by various tissues of the human body.

The invention discloses a fruit lucid ganoderma health care beverage, which is characterized in that the invention contains 800 to 1200 parts of fruit beverage and 5 to 20 parts of lucid ganoderma according to parts by weight, the fruit beverage is one of fruit wine and fruit juice, the lucid ganoderma powder is smashed and soaked, the juice is taken by a filter press and is blended with the fruit beverage, the impurities and suspension matters are filtered to prepare the invention; the invention has unique flavor, good taste and rich nutrition, the long-term drinking of the invention can improve the functions of coronary artery, improve the central nervous diseases and have certain prevention and treatment effects on coronary heart disease, chronic hepatitis and insomnia; the preparation method of the invention has simple process and low production cost, and the invention can bring the health care functions of the contained ingredients into full play.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a drug for treating transient ischemic attack, wherein the traditional Chinese medicine composition is prepared from 11 traditional Chinese medicines including astragalus membranaceus, ginseng, salviae miltiorrhizae and the like. A clinical experiment proves that the traditional Chinese medicine composition is significant in treatment effects on the transient ischemic attack.