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Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease

A technology of extracts and cockroaches, which can be used in cardiovascular diseases, medical raw materials derived from arthropods, anti-inflammatory agents, etc., can solve the problems that the application potential of cockroach extracts needs to be further developed and utilized, and improve microcirculation , reduce pulmonary artery pressure, increase the effect of coronary flow

Active Publication Date: 2012-02-15
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern scientific research shows that cockroach extract has strong biological activity, but there are still great limitations in the application of cockroach extract in the existing technology, and the application potential of cockroach extract needs to be further developed and utilized

Method used

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  • Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease
  • Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease

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preparation example Construction

[0019] The preparation method of described cockroach extract further comprises:

[0020] A. In the oil-water separation step, after introducing the alcohol-extracting thick paste into the oil-water separator, add 4 to 6 times the weight of purified water and stir thoroughly, and let it stand until the layers are obvious, remove the bottom sediment and the upper layer of grease, and collect the brown medicine in the middle layer liquid;

[0021] B. In the column separation step, add activated carbon for medical injections with a particle size of 200 to 325 meshes to the Chinese medicine liquid, stir well and stand still for 1 to 2 hours until the medicine liquid is absorbed into a colorless column, drain the liquid, and add water to saturate normal Elute with butanol or 5-10% phenol aqueous solution, collect the eluted drug solution, and elute until the color of the drug solution is no darker than No. 4 yellow colorimetric solution; the eluted drug solution is concentrated unde...

Embodiment 1

[0069] Get 1000g of dry insect body powder of cockroaches, add 5L of 90% ethanol and soak for 48 hours, then use 90%% ethanol as a solvent to slowly infiltrate until the filtrate is slightly yellow, and the filtrate is concentrated under reduced pressure to obtain a thick paste, while reclaiming ethanol; After the thickened alcohol extraction paste is introduced into the oil-water separator, add 4 times the weight of purified water to fully stir, let it stand until the layers are obvious, remove the bottom sediment and the upper layer of grease, and collect the brown liquid in the middle layer; 325-mesh activated carbon for medical injections, fully stirred and rested for 1 hour, until the liquid is absorbed into a colorless column, then drained the liquid, added water-saturated n-butanol to elute, collected the eluted liquid, and eluted to the liquid The color is not darker than No. 4 yellow colorimetric solution; the eluting liquid is concentrated under reduced pressure at 60...

Embodiment 2

[0072] Take 1000g of dried cockroach body powder, add 10L of 95% ethanol and soak for 60 hours, then use 95% ethanol as solvent to slowly infiltrate until the filtrate is slightly yellow, and the filtrate is concentrated under reduced pressure to obtain a thick paste, and the ethanol is recovered at the same time; After the thickening cream is introduced into the oil-water separator, add 6 times the weight of purified water and stir thoroughly, and let it stand until the stratification is obvious, remove the bottom sediment and the upper layer of grease, and collect the middle brown liquid medicine; the medicine liquid is added to the particle size of 325 mesh Activated carbon for injection, fully stirred and rested for 2 hours, until the liquid is absorbed into a colorless column, drain the liquid, add 5% phenol aqueous solution to elute, collect and elute the liquid, and elute to the color of the liquid Not deeper than No. 4 yellow colorimetric solution; the eluting liquid is...

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Abstract

The invention provides a cockroach extract, a preparation method thereof, and application of a cockroach extract preparation in treatment of cardiovascular disease. The cockroach extract comprises the following components (based on dry weight): 20-40% of composite nucleoside base, 30-60% of associated amino acid, 2-4% of uracil, 3-6% of hypoxanthine and 5-10% of inosine. The preparation method comprises the following steps of: pulverizing dried cockroach into coarse powder, carrying out percolation or reflux extraction with 90-95% ethanol to obtain dense paste, carrying out oil-water separation, and removing precipitate and oil to obtain water-layer drug liquid; and adsorbing with activated carbon, carrying out secondary alcohol extraction and water extraction, decolorizing, carrying out ultrafiltration and concentrating to obtain the cockroach extract dense paste. Combined with proper pharmaceutical auxiliary materials, the cockroach extract can be prepared into aqueous injection, freeze-dried powder injection, capsules, granules, tablets, oral liquid, dropping pills and other various dosage forms, and the obtained preparation can be used for treating cardiovascular disease, particularly heart failure caused by pulmonary heart disease, cardiomyopathy, rheumatism, coronary disease, high-altitude heart disease and the like.

Description

technical field [0001] The invention belongs to the technical field of biological extraction and pharmacy, further belongs to the technical field of cockroach extraction and pharmacy, and specifically relates to a cockroach extract and its preparation method and its application in treating cardiovascular diseases. Background technique [0002] The cockroach, also known as the American cockroach (commonly known as the cockroach), is the largest in the family Blatella, with an adult body length of 29-35 mm. The epidermis of the cockroach contains sclera and chitin, elements such as bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, and magnesium. Thirteen kinds of amino acids can be obtained by hydrolysis of the muscles, and there are also micronutrients stored in the body. Vitamins B1, B2, niacin and ascorbic acid, etc. Lymph contains trehalose, trehalase, glycoprotein, inositol, protocatechuic acid glucoside, etc.; the whole ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P9/00A61P9/04A61P9/10A61P29/00A61K31/7076A61K31/522A61K31/513
Inventor 李筱玲邵维在万德生段兆炜周应硕
Owner YUNNAN TENGCHONG PHARMA FACTORY
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