Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for treatment of abnormal energy metabolism and application thereof

A technology of energy metabolism and composition, which is applied in the direction of drug combination, metabolic diseases, medical preparations containing active ingredients, etc., can solve the problems of fatty acid and glucose metabolism imbalance, no drug energy metabolism, mitochondrial dysfunction, etc. Rehabilitation, Treatment of Mitochondrial Dysfunction, Effects of Optimal Energy Production

Active Publication Date: 2014-06-11
CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fatty acid oxidation consumes more oxygen than glucose oxidation, and it can only play a role in the case of sufficient oxygen supply, and it is inappropriate to promote fatty acid oxidation one-sidedly under the condition of ischemia and hypoxia
[0008] In addition to the above two types of drugs, no better drugs have been found clinically for the treatment of abnormal energy metabolism, imbalance of fatty acid and glucose metabolism, and mitochondrial dysfunction
And above-mentioned drugs all have certain defect clinically

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treatment of abnormal energy metabolism and application thereof
  • Pharmaceutical composition for treatment of abnormal energy metabolism and application thereof
  • Pharmaceutical composition for treatment of abnormal energy metabolism and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 The curative effect of trimetazidine and levocarnitine pharmaceutical composition on acute myocardial ischemia-reperfusion injury in rats, the curative effect on abnormal energy metabolism caused by myocardial ischemia, and the effect on the comprehensive balance of fatty acid and glucose metabolism , and efficacy against mitochondrial dysfunction.

[0067] During acute ischemia and reperfusion of the myocardium, due to insufficient oxygen, the energy supply of the myocardium changes from aerobic oxidation of fatty acids to glycolysis to provide energy. Therefore, a large amount of lactic acid produced by glycolysis leads to accumulation of acid products, A series of pathological changes such as aggravated peroxidation and damage to myocardial ultrastructure.

[0068] In order to observe the prevention and treatment effects of trimetazidine, levocarnitine and different ratios on acute myocardial ischemia-reperfusion injury, abnormal energy metabolism, and mito...

Embodiment 2

[0110] Example 2 Efficacy of Levocarnitine and Trimetazidine Composition in Treating Metabolic Syndrome and Abnormal Energy Metabolism

[0111] 2.1 Modeling method:

[0112] Animals: ordinary male Wistar rats, body weight 200±20g; after feeding with ordinary feed for 1 week, a) each model group was given high-sugar, high-fat, and high-salt feed (basic feed 58%, lard oil 8%, sucrose 22% , egg yolk 10%, salt 2%) to detect modeling indexes after 8 weeks. b) Normal control group: fed with common feed (containing 0.5% salt) for 8 weeks. All animals had free access to food and water

[0113] 2.2 Test drugs and grouping

[0114] 1) Drugs: Levocarnitine and trimetazidine hydrochloride were provided by Changzhou Sanwei Industrial Research Institute.

[0115] Solvent: normal saline. The test drug was prepared with normal saline to make an equal volume solution of corresponding concentration before use.

[0116] 2) Dose setting and experimental grouping

[0117] After the equivalent...

Embodiment 3

[0147] Example 3 Efficacy of Levocarnitine and Trimetazidine Composition in Treating Abnormal Energy Metabolism of Liver Cancer

[0148] 3.1 Experimental method and dose setting

[0149] BALB / c mice, male. Weight 20-22g. 15 mice were randomly selected from each batch of 36 mice as the healthy group.

[0150] The remaining groups were subcutaneously injected with HepA cell suspension in the right forelimb, each 0.2mL (5x10 / ml) to prepare liver cancer samples.

[0151] Body tumor model. After the equivalent doses of trimetazidine and levocarnitine were calculated based on clinical human doses, each

[0152] There are 2 dosage groups, 4 groups including solvent group and control group. They are:

[0153] Trimetazidine (TMZ) group: solvent control group, TMZ 48mg / kg administration group, intraperitoneal injection.

[0154] L-carnitine (L-C) group: solvent control group, L-C 340mg / kg administration group, intragastric administration.

[0155] Trimetazidine + levocarnitine d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to View More

Abstract

The pharmaceutical compositions for treating abnormal energy metabolism, comprising a) medicines for promoting oxidation of fatty acid or derivatives thereof, particularly levocarnitine, and b) medicines for promoting oxidation of glucose or pharmaceutically acceptable salts thereof, particularly trimetazidine, are provided in the present invention. The said pharmaceutical composition can also auxiliarily treat many kinds of diseases such as acute or chronic ischemia, trauma, severe infection, diabetes and tumor etc.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating abnormal energy metabolism, which is used for regulating the imbalance of glucose and fatty acid metabolism and mitochondrial dysfunction. technical background [0002] In the life activities of animals, in addition to the exchange of oxygen and carbon dioxide, the decomposition and synthesis of glucose, fatty acids and proteins are also required, and the conversion of energy storage and consumption is required to meet the needs of life activities. Protein is an important component of the body's cells, and there is usually no redundant storage. Therefore, under normal circumstances, it is necessary to save protein consumption as much as possible, and the energy supply is mainly based on the oxidation of glucose and fatty acids. Usually, sugar oxidation accounts for about 50-70% of the total energy supply of the human body. Fat is the main energy storage method of the body, which can rea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/495A61P1/00A61P1/08A61P1/16A61P3/00A61P3/10A61P5/00A61P7/08A61P9/00A61P9/10A61P9/12A61P11/00A61P13/12A61P15/00A61P17/00A61P19/00A61P21/00A61P21/04A61P25/00A61P25/06A61P39/02A61K31/205
CPCA61K31/495A61K31/205A61P1/00A61P1/02A61P1/04A61P1/08A61P1/12A61P1/16A61P1/18A61P3/00A61P3/10A61P5/00A61P7/08A61P9/00A61P9/10A61P9/12A61P11/00A61P13/12A61P15/00A61P17/00A61P19/00A61P21/00A61P21/04A61P25/00A61P25/06A61P25/14A61P25/28A61P31/00A61P35/00A61P39/02A61P43/00Y02A50/30A61K2300/00
Inventor 顾书华杜娟
Owner CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com