87results about How to "Not easy to dissociate" patented technology

The invention relates to preparation and application of a reducing sensitive nano-micelle, belonging to preparation and application of an amphiphilic block polymer. A hydrophilic section and a hydrophobic section of the amphiphilic block polymer are connected with each other by a reducing responsive sulfur-sulfur bond; the nano-micelle is formed by self-assembling; the reducing sensitive nano-micelle consists of a shell and an inner core, wherein the shell is a hydrophilic polymer, and the inner core is a hydrophobic polymer; the hydrophilic section of the amphiphilic block polymer is polyphosphate, the hydrophobic section of the amphiphilic block polymer is poly(benzyl glutamate), and the hydrophilic section and the hydrophobic section of the amphiphilic block polymer are connected with each other by the reducing responsive sulfur-sulfur bond. The reducing sensitive nano-micelle has the advantages that the drug-loaded nano-micelle is difficult to dissociate outside the cells or in the blood, so that the drug encapsulated in the nano-micelle is enabled to be stable; once the nano-micelle enters the cancer cell, the sulfur-sulfur bond can be disconnected by glutathione which is a reducing matter in the cell, so that the nano-micelle is rapidly dissociated, the anti-cancer drug encapsulated in the nano-micelle can be rapidly and effectively released out, and an effective treatment effect is achieved; the reducing sensitive nano-micelle overcomes the defects that the drug is easy to leak in vivo, low in transport efficiency, slow in intracellular release speed, and the like.

The invention relates to a method for separating and culturing human adipose-derived stem cells. The method comprises the following steps: (1) digesting an adipose suction substance by adopting a mixed digestive enzyme solution which consists of collagenase I, collagenase II and ACCUTASE, neutralizing the digestive enzyme after digesting is ended, centrifuging, filtering, and then further removinghybrid cells by using a lymphocyte separating liquid; (2) culturing adipose-derived stem cells by adopting a serum-free culture medium. According to the method for separating and culturing the humanadipose-derived stem cells, on one hand, cells can be dissociated from an adipose tissue quickly and effectively, the yield of the stem cells is improved, the cell separating time is shortened, and the activity of the cells is kept to the greatest extent; on the other hand, the culture medium is clear in components, does not contain any exogenous serum component, can remarkably improve the wall adhering capacity and the multiplication capacity of the adipose-derived stem cells, is beneficial to in-vitro amplification and stemness maintenance of the adipose-derived stem cells, and has a good application prospect.

The invention provides a preparation method of a high-efficiency leaching and adsorbing material for Cd contaminated soil and wastes and also discloses the high-efficiency leaching and adsorbing material prepared by the preparation method. The material has quicker and higher adsorption capacity for heavy metal Cd; besides, the material is low in price and easily-obtained and facilitates wide application of a leaching remediation method for heavy metal contaminated soil; meanwhile, sulfydryl (-HS) in sulfhydryl modified attapulgite clay serving as an adsorbing material can generate a stronger complexing action with heavy metal ions, and heavy metal is not easy to dissolute, so that the sulfhydryl modified attapulgite clay has important significance on repeated leaching and adsorbing; in addition, a pH value, obtained by measuring, of the sulfhydryl modified attapulgite clay is neutral and is relatively-stable, so the sulfhydryl modified attapulgite clay has no influence on leacheate or soil and better facilitates quick and efficient leaching.

The invention discloses a tablet for relieving physical fatigue. The tablet is prepared from the following raw materials in parts by weight: 400 to 500 parts of taurine, 90 to 110 parts of caffeine, 140 to 160 parts of L-lysine hydrochloride, 45 to 55 parts of inositol, 30 to 40 parts of nicotinamide and 4 to 6 parts of vitamin B6. The invention also discloses a preparation technology of the tablet for relieving the physical fatigue. The preparation technology disclosed by the invention creatively prepares health-care products into tablets and extracts the taurine and the caffeine from naturalsubstances; the safety of the tablet is higher than the safety of artificially synthesized products; the prepared product can significantly relieve the physical fatigue.

The invention discloses functional digestible micelle-state casein powder and a preparation method thereof. The preparation method comprises the following steps: pretreating skimmed milk, preparing micelle-state casein, preparing a compound of functional molecules and the micelle-state casein, and drying the compound, so as to obtain the functional micelle-state casein powder which is relatively good in compressibility, rapid in rehydration and relatively good in solubility and digestibility. The dissolvability and digestibility of the micelle-state casein product can be remarkably improved, so that the micelle-state casein product can be more easily digested into small molecule peptide in an organism. In addition, micellar casein is taken as a carrier, so that loading, delivery and slow release of the functional micromolecules are realized, bioavailability of the functional micromolecules is improved, and health-care effects of the casein and the functional micromolecules are brought into full play. The functional micelle-state casein powder prepared by the preparation method disclosed by the invention has wide application and wide market prospect no matter being used as a health-care product or a raw and auxiliary material in food and medicine industries.

The invention discloses a production method of a high-calcium-dissolution cucumber seed drink and belongs to the technical field of agricultural products.The production method comprises: adding acidified water into mature cucumber seed according to a certain proportion for pulping, holding a certain temperature and then filtering, and adding a thickening stabilizer and the like for preparation to obtain the high-calcium-dissolution cucumber seed drink.The problems that traditional powdery products are poor in eating convenience and low in soluble calcium content, thus affecting absorption and utilization, are solved, a novel cool high-calcium drink of all-natural plant calcium origin is developed, and this product has the advantages such as low cost, simple process, instant use and wide applicable range and has a promising market prospect.

The invention discloses a novel ecological, biological and physical purification and disinfection tap water treatment process. Source water sequentially passes through a microbial ecological tank, a multi-medium filter tank, a precision filter, a water molecule cutter and a disinfector; wherein the microbial ecological pool is provided with a porous floating bed, and aquatic plants are planted inholes of the porous floating bed; a plurality of nanofiber carriers and an aeration system are arranged in the microbial ecological tank; the multi-medium filter tank is a multi-stage filter tank, wherein an internal medium of the multi-medium filter tank is one or a mixture of more than two of zeolite mineralization sintered balls, volcanic mineralization sintered balls, medical stone mineralization sintered balls and quartz sand. The novel process for purifying river water, well water and reservoir water into drinking water is not limited by a water source, and any river water, well water and reservoir water can be treated to reach and be superior to the national drinking water standard.

The invention discloses a method for using gypsum slag to strengthen the recovery of valuable metals in copper smelting slag, comprising the following steps: (1) mixing the gypsum slag and a carbonaceous reducing agent uniformly, and granulating or tableting to obtain mixed granules or mixed flakes; (2) adding the obtained mixed pellets or mixed flakes into the high-temperature copper smelting slag; (3) slowly cooling the mixture obtained in step (2) to obtain slow cooling slag. Compared with the existing process, the method of the invention not only has low energy consumption, but also has high metal recovery rate, low cost, simple process, simple material, easy industrial application, and has high industrial application prospect and value.

The invention belongs to the technical field of adhesives, and particularly relates to a preparation method of a flame-retardant and waterproof adhesive for a corrugated carton. The preparation methodspecifically comprises the following steps: (1) an organic silicon modified emulsion is prepared; (2) a white prepolymer emulsion is prepared; (3) an acrylic modified flame-retardant organic siliconemulsion is prepared; and (4) 110-120 parts of the acrylic modified flame-retardant organic silicon emulsion is put into a high-speed mixer, 1.5-2.3 parts of carnallite powder, 24-27 parts of polyhalite powder and 5-7 parts of a flame retardant are added, even stirring and mixing are conducted, and then the flame-retardant and waterproof adhesive is obtained. The prepared adhesive is transparent,high in adhesion and good in stability, water-based adhesive bonding, quick drying, and acid and alkali resistance are achieved, no organic solvent is contained, the poisonless, tasteless, non-combustible, environment-friendly and pollution-free effects are achieved, and pollution-free production can be achieved. The flame-retardant and waterproof adhesive is suitable for the carton not coated andpolished, and the corrugated carton is protected very well.

The present invention discloses a temozolomide polymer prodrug and a preparation method and an application thereof. The temozolomide polymer prodrug comprises a hydrophilic polymer having a synthesizing terminal of a hydroxyl group and a temozolomide derivative having a synthesizing terminal of a carboxyl group; and the hydroxyl group of the terminal of the hydrophilic polymer reacts with the carboxyl group of the temozolomide derivative, the temozolomide is bonded to the terminal end of the hydrophilic polymer to obtain the temozolomide polymer prodrug. The temozolomide polymer prodrug is prepared by a covalent bond connection of the temozolomide and the polymer and can maintain stability in a body cycle; the temozolomide and the polymer are covalently bonded to form nanomicelles in water, the nanomicelles are not liable to dissociate extracellularly and in blood, and the temozolomide polymer prodrug solves problems that the temozolomide is liable to degrade under physiological conditions of the temozolomide, and drugs are easily leaked in body and short in cycle time, etc.

The invention relates to a phosphorus-nitrogen synergistic self-flame-retardant acrylic emulsion and a preparation method thereof. The method comprises the following steps: synthesizing a phosphorus flame-retardant vinyl monomer, and carrying out an emulsion copolymerization reaction on an acrylate monomer and the vinyl group-containing reactive flame-retardant vinyl monomer containing nitrogen and phosphorus to synthesize the self-flame-retardant acrylic emulsion containing nitrogen and phosphorus. The emulsion has a flame retardation effect without adding other flame retardants, and the flame-retardant phosphorus and nitrogen elements are combined with acrylic resin through chemical bonds and do not dissociate, so the emulsion has long-lasting flame resistance, and can be used in the fireproofing and flame retardation of woodenware coatings, anticorrosive coatings and building interior and exterior coatings.

The invention relates to a rice flour making method for improving the tasty effect of rice flour. The rice flour making method comprises the following steps of (1) making rice into rice flour, addingwater, performing stirring uniformly, adding saccharomyces cerevisiae and alpha-amylase, and performing fermenting at constant temperature to obtain rice milk; (2) adding alkaline protease into the rice milk, and carrying out enzymolysis; (3) adding oleic acid into the zymolytic rice milk for performing pulping, and then adding potato starch and composite phosphate for performing pulping; (4) performing cooking to be pasty; (5) performing extruding to form rice noodles; and (6) performing cooking and cooling on the rice noodles to obtain finished rice flour. A method of combining alpha-amylaseand saccharomycetes is adopted, the alpha-amylase can promote proliferation of the saccharomycetes, the saccharomycetes can produce gas in the fermentation process, and the fresh and wet rice flour can be promoted to form a uniform porous structure; and meanwhile, oleic acid is added in the making process, oleic acid can be combined with starch, and therefore grease and fat-soluble substances canenter the fresh and wet rice flour more easily, so that the tasty effect of the rice flour is enhanced.

The invention discloses a hydrogen methyl esterification reaction catalyst and a method for preparing isononanoic acid. The catalyst comprises an active metal and a ligand, and the active metal is a compound containing cobalt and / or rhodium; the structural formula of the ligand is wherein X 1 、X 2 、X 3 The same or different, all are nitrogen-containing heterocyclic groups. The catalyst is suitable for preparing isononanoic acid methyl ester through hydrogen methyl esterification reaction of diisobutene, methanol and carbon monoxide as raw materials, and then further hydrolyzing to obtain isononanoic acid. The catalyst can improve the conversion rate and the selectivity of the target product, and the yield of the isononanoic acid product reaches 92.9%. The process of the method is relatively simple, the raw material cost is low, the safety is high, and the product yield is high, so the method has good application prospects.