92 results about "Thioctic Acid" patented technology

The invention discloses a thiol-polyethylene glycol modified magneto-optical composite nano-material and its application. An up-conversion nano material is taken as a basal layer, the surface of the basal layer is provided with a polyacrylic acid layer, the surface of the polypropylene layer is provided with a layer of dopamine modified ferriferrous oxide magnetic particles, a golden shell layer is covered on the dopamine modified ferriferrous oxide magnetic particles layer, and the thioctic acid modified polyethylene glycol is provided on the golden shell layer; the thiol-polyethylene glycolmodified magneto-optical composite nano-material has guidance functions of up-conversion imaging and magnetic resonance imaging dual imaging, under the physical induction action of the magnetic field, the nano-material of the invention enables magnetic targeting to the specific position, so that the distribution in other internal organs can be reduced, and the damage in other internal organs during the treatment process is reduced. The nano-material can be taken as a good reagent for photo-thermal treatment by using the strong absorption property on the surface. The magnetic targeting photo-thermal treatment is combined under the imaging guidance, thereby the composite nano-material of the invention plays an important effect in clinical medical science and biological technology in future.

The invention discloses a branched gold-platinum dual-metal nanoparticle as well as a preparation method and application thereof. The gold-platinum dual-metal nanoparticle has photo-thermal / radio-sensitization combined treatment performance and structurally contains gold-platinum nanoparticles and polyethylene glycol, wherein the gold-platinum nanoparticles are used for photo-thermal / radio-sensitization combined treatment, and polyethylene glycol is used for the surface modification of a thioctic acid terminal of a hydrophilic polymer. The gold-platinum dual-metal nanoparticle can be applied to the photo-thermal / radio-sensitization combined treatment and has the advantages of simplicity in preparation, low cost and remarkable treatment effect.

The invention discloses antioxidant composition. The antioxidant composition is prepared from the following raw materials: a polygonum cuspidatum extract, a turmeric extract, a green tea extract, alpha-lipoic acid and a coenzyme Q10. The invention further discloses a preparation method and application of the antioxidant composition. The antioxidant composition combines the polygonum cuspidatum extract, the turmeric extract, the green tea extract, the alpha-lipoic acid and the coenzyme Q10 for use, so that the antioxidant composition has a significant antioxidant effect, can effectively inhibit generation of oxygen free radicals, and can be used for treating and / or preventing ischemia-reperfusion injuries.

The invention discloses an improved Neurobasal B27 culture medium. One liter of a Neurobasal culture solution comprises 0.09-0.11 g of biotin, 18-22 micrograms of corticosterone, 1-3 g of L-carnitine, 0.9-1.1 g of linoleic acid, 0.9-1.1 g of ethanol amine, 0.9-1.1 g of linolenic acid, 13-17 g of D(+)-galactose, 6-7 micrograms of progesterone, 15-17 g of putrescine dihydrochloride, 0.08-0.12 g of retinyl acetate, 2.2-2.8 g of thyroid-hormone-removing bovine serum albumin, 0.8-1.5 g of DL-alpha-tocopherol, 2-3 g of catalase, 0.9-1.2 g of DL-alpha-tocopheryl acetate, 0.8-1.3 g of reduced glutathione, 42-52 micrograms of lipoic acid, 2-3 g of superoxide dismutase, 4-6 g of transferring, 3-5 g of human insulin and 0.12-0.16 mg of sodium selenite. The invention further discloses a preparing method and application of the improved Neurobasal B27 culture medium. The improved Neurobasal B27 culture medium can be used for researching the influence of thyroid hormones on the process that embryonic stem cells are differentiated into nerve cells.

Disclosed is a recovering method for the mixture waste gas of the chlorine hydride and the sulfur dioxide in the thioctic acid production, which belongs to the mixture waste gas recovery technical field in the thioctic acid production. The recovering method includes that the mixture waste gas of the chlorine hydride and the sulfur dioxide is introduced to a water absorption device through the pipeline; when the concentration of the chlorine hydride solution in the water absorption reaches the discharge concentration, the chlorine hydride is recovered; the purified sulfur dioxide gas after the adsorption of the chlorine hydride gas is sucked to the reactor device by the pipeline in the vacuum way and reacts with the sodium hydroxide solution in steps while the chlorine hydride gas is absorbed by the water absorption device; the reaction temperature and the PH value are respectively controlled and adjusted in steps so that the sodium sulfite solution is obtained; the sodium sulfite solution is discharged from the reactor device and fed to a centrifugal separation device for centrifugal separation, so as to obtain the seven hydrate sodium sulfite crystal; the mother liquor obtained through the centrifugal separation is fed to the reactor device again. The recovering method for the mixture waste gas of the chlorine hydride and the sulfur dioxide has the advantages of environmental protection, resource maximum utilization and saving production cost for the thioctic acid production enterprises.

A freeze-dried powder injection of thioctic acid contains proprotionally the thioctic acid, antioxidizing agent and pH regulator. Its advantages are high curative effect and high stability.

The invention discloses a stable pharmaceutical composition. The stable pharmaceutical composition contains (6S)-5-methyl-calcium tetrahydrofolate crystal and / or pharmacologically acceptable reducingsubstances as well as pharmacologically acceptable auxiliaries, wherein the reducing substances can protect (6S)-5-methyl-tetrahydrofolic acid and a salt thereof from being oxidized, and are selectedfrom vitamin C and a salt thereof, iso-vitamin C and a salt thereof, mercaptoethanol, cysteine, mercaptoethyl sulfoacid, dithiothreitol, reduced glutathione and thioctic acid. The stable pharmaceutical composition provided by the invention has good stability during processing and storage, avoids drug use risk caused by degradation, and ensures quick and reliable release of (6S)-5-methyl-tetrahydrofolic acid in the composition.

The present invention relates to compositions and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the composition provides a nutritional supplement with a beneficial increased supplementation of vitamin D and the method involves administering to an individual a composition comprising carotenoids, vitamin E, vitamin D, vitamin C, thiamine, riboflavin, niacin, folic acid, pyridoxine, biotin, pantothenic acid, cobalamin, magnesium, manganese, zinc, selenium, chromium, copper, alpha lipoic acid, and lutein.

The invention relates to the technical field of chemical synthesis, in particular to thio-octyl phosphoramido ester and a synthetic method and application thereof. The synthetic method of the thio-octyl phosphoramido ester includes the step of: adopting thioctic acid as a raw material, performing a reduction reaction to obtain thio-octanol, and performing an esterification reaction to obtain the thio-octyl phosphoramido ester. When the thio-octyl phosphoramido ester is used as a DNA end-group modifier, DNA with sulfur-containing modified end groups can be prepared efficiently and massively, and the simple and efficient DNA end-group modifier with controllable cost can be provided for sulfur-containing modification of a 5' end of DNA; meanwhile, the synthetic method has the advantages of aconcise path, convenient operation, a simple method for purifying intermediates and the product, and requirements of scientific research and business can be fully met.

The invention provides a thioctic acid dispersible tablet and a preparation method thereof. The thioctic acid dispersible tablet contains thioctic acid, a disintegrating agent, a binder and a lubricant, wherein the lubricant does not contain magnesium stearate.